ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MLLHLGGSRA KTGILLIRRA GLFCRSAHLS SQTLEYHPIK KVMVANRGEI AIRVFRACTE 

        70         80         90        100        110        120 
LGIRTVAVYS EQDTGQMHRQ KADEAYLIGR GLSPVAAYLH IPDIIKVAKE NNVDAIHPGY 

       130        140        150        160        170        180 
GFLSERADFA QACAEAGVRF IGPSPEVVRK MGDKVEARAL AIKAGVPVVP GTDAPISCLQ 

       190        200        210        220        230        240 
EAQEFAKTYD FPIIFKAAYG GGGRGMRVVR NYEELEENYQ RAYSEALAAF GNGALFVEKF 

       250        260        270        280        290        300 
IEKPRHIEVQ ILGDKYGNVI HLYERDCSIQ RRHQKVVEIA PAAHLDSHLR DRLTLDSVNL 

       310        320        330        340        350        360 
AKQVGYENAG TVEFLVDKHG KHYFIEVNSR LQVEHTVTEE ITDVDLVHAQ LRVCEGRSLP 

       370        380        390        400        410        420 
ELGLEQDKIQ INGCAIQCRV TTEDPSRGFQ PDTGRIEVFR SGEGMGIRLD SASAFQGAII 

       430        440        450        460        470        480 
SPHYDSLLVK VIASGKDLPT AATKMHRALT EFRVRGVKTN IPFLQNVLSN SQFLYATVDT 

       490        500        510        520        530        540 
QFIDENQNLF NLKPTQNRAQ KLLHYLGHVM VNGPMTPIPV KAKPSPVDPV IPSVSLGEPP 

       550        560        570        580        590        600 
LGFREVLLRE GPEGFARAIR QHQGLLLMDT TFRDAHQSLL ATRVRTHDLK KIAPYVSHNF 

       610        620        630        640        650        660 
SNLFSLENWG GATFDAAMRF LSECPWKRLQ ELRALIPNVP FQMLLRGANA VGYTNYPDNA 

       670        680        690        700        710        720 
VFKFCEVAKE NGMDIFRVFD SLNYIPNMLL GMEAAGAAGG VVEAAISYTG DVSDPMRQKY 

       730        740        750        760        770        780 
SLDYYLKLAD ELVKAGTHIL SIKDMAGLLK PQASRLLIEA LRDRFPDIPI HVHTHDTAGA 

       790        800        810        820        830        840 
GVAAMLACAQ AGADIVDVAV DSMAGMTSQP SMGAIVACTK GTKLDTGISL DKVFDYSEYW 

       850        860        870        880        890        900 
EVARGLYAPF DCTATMKSGN ADVYENEIPG GQYTNLHFQA HSMGLGNKFK EVKKAYTEAN 

       910        920        930        940        950        960 
KLLGDLIKVT PSSKIVGDLA QFMVQNLSRA EVEKRADELS FPLSVVEFLQ GHIGIPHGGF 

       970        980        990       1000       1010       1020 
PEPFRSKVLK SLPRIEGRPG ASLPPMDFEA LESGLRAAHG DEITPEDVMS AAMYPKVFQE 

      1030       1040       1050       1060       1070       1080 
FKEFTSTFGP VDCLNTRLFL DGPKIAEEFQ VELERGKILH IKALALGDLN KSGQREVFFE 

      1090       1100       1110       1120       1130       1140 
LNGQLRSVLV KDTAAMKEMH FHPKALKDVR GQVGAPMPGK VVEVKVKAGQ KVEKGQPLCV 

      1150       1160       1170       1180 
LSAMKMETVV NSPISGIISK VHVNADSSLE GEDLILEITE 

References and documentation are available.

Number of amino acids: 1180

Molecular weight: 129884.19

Theoretical pI: 6.44

Amino acid composition: 
Ala (A) 111	  9.4%
Arg (R)  64	  5.4%
Asn (N)  40	  3.4%
Asp (D)  61	  5.2%
Cys (C)  15	  1.3%
Gln (Q)  46	  3.9%
Glu (E)  81	  6.9%
Gly (G)  94	  8.0%
His (H)  36	  3.1%
Ile (I)  65	  5.5%
Leu (L) 112	  9.5%
Lys (K)  68	  5.8%
Met (M)  32	  2.7%
Phe (F)  53	  4.5%
Pro (P)  60	  5.1%
Ser (S)  64	  5.4%
Thr (T)  49	  4.2%
Trp (W)   3	  0.3%
Tyr (Y)  32	  2.7%
Val (V)  94	  8.0%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 142
Total number of positively charged residues (Arg + Lys): 132

Atomic composition:

Carbon      C	      5791
Hydrogen    H	      9189
Nitrogen    N	      1601
Oxygen      O	      1696
Sulfur      S	        47

Formula: C5791H9189N1601O1696S47
Total number of atoms: 18324

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    65055
Abs 0.1% (=1 g/l)   0.501, assuming all pairs of Cys residues form cystines


Ext. coefficient    64180
Abs 0.1% (=1 g/l)   0.494, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.75
This classifies the protein as stable.



Aliphatic index: 91.01

Grand average of hydropathicity (GRAVY): -0.144