ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MLQEQSELMS TVMNNTPTTV AALAAVAAAS ETNGKLGSEE QPEITIPKPR SSAQLEQLLY 

        70         80         90        100        110        120 
RYRAIQNHPK ENKLEIKAIE DTFRNISRDQ DIYETKLDTL RKSIDKGFQY DEDLLNKHLV 

       130        140        150        160        170        180 
ALQLLEKDTD VPDYFLDLPD TKNDNTTAIE VDYSEKKPIK ISADFNAKAK SLGLESKFSN 

       190        200        210        220        230        240 
ATKTALGDPD TEIRISARIS NRINELERLP ANLGTYSLDD CLEFITKDDL SSRMDTFKIK 

       250        260        270        280        290        300 
ALVELKSLKL LTKQKSIRQK LINNVASQAH HNIPYLRDSP FTAAAQRSVQ IRSKVIVPQT 

       310        320        330        340        350        360 
VRLAEELERQ QLLEKRKKER NLHLQKINSI IDFIKERQSE QWSRQERCFQ FGRLGASLHN 

       370        380        390        400        410        420 
QMEKDEQKRI ERTAKQRLAA LKSNDEEAYL KLLDQTKDTR ITQLLRQTNS FLDSLSEAVR 

       430        440        450        460        470        480 
AQQNEAKILH GEEVQPITDE EREKTDYYEV AHRIKEKIDK QPSILVGGTL KEYQLRGLEW 

       490        500        510        520        530        540 
MVSLYNNHLN GILADEMGLG KTIQSISLIT YLYEVKKDIG PFLVIVPLST ITNWTLEFEK 

       550        560        570        580        590        600 
WAPSLNTIIY KGTPNQRHSL QHQIRVGNFD VLLTTYEYII KDKSLLSKHD WAHMIIDEGH 

       610        620        630        640        650        660 
RMKNAQSKLS FTISHYYRTR NRLILTGTPL QNNLPELWAL LNFVLPKIFN SAKTFEDWFN 

       670        680        690        700        710        720 
TPFANTGTQE KLELTEEETL LIIRRLHKVL RPFLLRRLKK EVEKDLPDKV EKVIKCKLSG 

       730        740        750        760        770        780 
LQQQLYQQML KHNALFVGAG TEGATKGGIK GLNNKIMQLR KICNHPFVFD EVEGVVNPSR 

       790        800        810        820        830        840 
GNSDLLFRVA GKFELLDRVL PKFKASGHRV LMFFQMTQVM DIMEDFLRMK DLKYMRLDGS 

       850        860        870        880        890        900 
TKTEERTEML NAFNAPDSDY FCFLLSTRAG GLGLNLQTAD TVIIFDTDWN PHQDLQAQDR 

       910        920        930        940        950        960 
AHRIGQKNEV RILRLITTDS VEEVILERAM QKLDIDGKVI QAGKFDNKST AEEQEAFLRR 

       970        980        990       1000       1010       1020 
LIESETNRDD DDKAELDDDE LNDTLARSAD EKILFDKIDK ERMNQERADA KAQGLRVPPP 

      1030       1040       1050       1060       1070       1080 
RLIQLDELPK VFREDIEEHF KKEDSEPLGR IRQKKRVYYD DGLTEEQFLE AVEDDNMSLE 

      1090       1100       1110       1120       1130       1140 
DAIKKRREAR ERRRLRQNGT KENEIETLEN TPEASETSLI ENNSFTAAVD EETNADKETT 

      1150       1160       1170       1180       1190       1200 
ASRSKRRSSR KKRTISIVTA EDKENTQEES TSQENGGAKV EEEVKSSSVE IINGSESKKK 

      1210       1220       1230       1240       1250       1260 
KPKLTVKIKL NKTTVLENND GKRAEEKPES KSPAKKTAAK KTKTKSKSLG IFPTVEKLVE 

      1270       1280       1290       1300       1310       1320 
EMREQLDEVD SHPRTSIFEK LPSKRDYPDY FKVIEKPMAI DIILKNCKNG TYKTLEEVRQ 

      1330       1340       1350 
ALQTMFENAR FYNEEGSWVY VDADKLNEFT DEWFKEHSS 

References and documentation are available.

Number of amino acids: 1359

Molecular weight: 156742.92

Theoretical pI: 6.30

Amino acid composition: 
Ala (A)  81	  6.0%
Arg (R)  87	  6.4%
Asn (N)  71	  5.2%
Asp (D)  91	  6.7%
Cys (C)   6	  0.4%
Gln (Q)  67	  4.9%
Glu (E) 135	  9.9%
Gly (G)  50	  3.7%
His (H)  24	  1.8%
Ile (I)  85	  6.3%
Leu (L) 145	 10.7%
Lys (K) 129	  9.5%
Met (M)  24	  1.8%
Phe (F)  49	  3.6%
Pro (P)  44	  3.2%
Ser (S)  83	  6.1%
Thr (T)  89	  6.5%
Trp (W)  10	  0.7%
Tyr (Y)  30	  2.2%
Val (V)  59	  4.3%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 226
Total number of positively charged residues (Arg + Lys): 216

Atomic composition:

Carbon      C	      6900
Hydrogen    H	     11143
Nitrogen    N	      1945
Oxygen      O	      2152
Sulfur      S	        30

Formula: C6900H11143N1945O2152S30
Total number of atoms: 22170

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   100075
Abs 0.1% (=1 g/l)   0.638, assuming all pairs of Cys residues form cystines


Ext. coefficient    99700
Abs 0.1% (=1 g/l)   0.636, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 40.74
This classifies the protein as unstable.



Aliphatic index: 84.55

Grand average of hydropathicity (GRAVY): -0.727