Home  |  Contact

ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MLQQHGISFQ MNADRQNKAA TTSNRIVSAP ATNEFDERHR KQGIDAARAL ASQYRSRITE 

        70         80         90        100        110        120 
NRDANQRQAA RELSRYVRSE LKDEPNTFSD AFLNAIDGRT DIASQSAIYN CMKSNSNIDQ 

       130        140        150        160        170        180 
KRAGIYLIVC LAETHSGNVI RYANYLLKML NNGNGLDEDT VKMASKALAF LIATCKSYAA 

       190        200        210        220        230        240 
ELVDRCLDHC HEWLGQNVPH SQQPKNQQEI DQIRRLAASH LSRELALATP TAFFLRVNLF 

       250        260        270        280        290        300 
FKYIFNAVRD KNPAVRIAGI DALHVVLTIV SQREAKNKTE WFKKCFDEAL EGQPNPSQKD 

       310        320        330        340        350        360 
DLDRWHAVAL ILNELLRISD QRFELIRCES SQFIKQKFLK EDEEEGVEWL VLTKQQTIVE 

       370        380        390        400        410        420 
SVTARKLVLE RFPKILDCVR QIIPLANKTS STKQQSSIYL NTVLMQLLPR ICAFPQCDRT 

       430        440        450        460        470        480 
FQTISFDTSF TILQRNAVAA PAIGMMMLSN PDVHATHIEK TISFISAAIK KTTNSDVLDN 

       490        500        510        520        530        540 
YFTFLFLFVD AYHEQVTTQI KAIIPQLMDI TLSRSLANVL KMIMMRIPKL RLNVQDGVMA 

       550        560        570        580        590        600 
SVYQTLTGSL IPPKSEPIGR PASPKAILQK AETDPKELQR IVLAVDVLGE FYFSRGALQR 

       610        620        630        640        650        660 
IMQYVADYYL TADNVEIRLA AVSSCCEMVV PFVGVYKKVT SDKRNSLLQT IYGVLRAVCS 

       670        680        690        700        710        720 
VIVNDQDVRV RMQVISCFGQ MPRPFLAHLA QPEMLEVQFM ALHDEKLEMQ QACVTLLGRL 

       730        740        750        760        770        780 
AELNPALVLP RLRLMLLETL SQMQQSGQAR LEQHSAKMIA QLAKQSPKFM RPYVGSLMIA 

       790        800        810        820        830        840 
MIPKLRNDQK YAEVTAQVLN AVSEIAVIGG AEIVKNLKPL FEKLTHMIND SSSLHKREAA 

       850        860        870        880        890        900 
LRAIGGICRS TAYVVDPYRD YPSLLDDLLR ILKTVMSNTM RREAIKTLGI LGAIDPYTHK 

       910        920        930        940        950        960 
VFTGSVQSST AISTALSLPI SETDSKDPRQ DIIHWFNYEK CTLEEFYPAI TIANLMLMMQ 

       970        980        990       1000       1010       1020 
DEDSQSYAEI AQAIVTIFRS LGDMAPLYTE QVIPRLIEVC RRATESSNRA NLREFFLQQL 

      1030       1040       1050       1060       1070       1080 
ANFVAIIRKH AAPYMPAIFT IIADAWKEDI SVKMVVIEVL TDMGTAIGND FSKYTGELIP 

      1090       1100       1110       1120       1130       1140 
YLLTVLQTDK TKERVLTVKV MESIQKLTHC IVQHLHLVLP PLLIILDDFS LKLSIRNTAL 

      1150       1160       1170       1180       1190       1200 
STVLHMTQQV DVSAYAPRMM QSWHHNISTA EMRDKLLLLL IEIIKQLGKF FDIFKRGVDQ 

      1210       1220       1230       1240       1250       1260 
KLRDYNLDKS VHYEQYRKLA QRAQMSRDVL TSSVFAGSNG NIQYSSTQAG MRGQANNVYA 

      1270       1280       1290       1300       1310       1320 
NNDLHERLMN GSIDSGASRQ DNRDDYYRYG VEEKKEVPKV APTTARPTSE LVTVQITKQR 

      1330       1340       1350       1360       1370       1380 
LNKDALMPQW KNENLTSKDE WLQWLMKIRI GFLTYGSSPS LRAASSLGDQ HPHLARDLFP 

      1390       1400       1410       1420       1430       1440 
AAFMSVWTEL DSDVQNDLTS CLLRAISTGI PELIQTILNL AEFMDHSEKG PLPISHDVLG 

      1450       1460       1470       1480       1490       1500 
RWAEQTKAFA KACRYKEMSV LKKSGSMQTT FTRKVKLEPN DCQSLITYAN KLNVQEEAAG 

      1510       1520       1530       1540       1550       1560 
VVRYAERNEM NFQMRGRWYE KLNEWEKALG AYELEEKKKS SCPNLQVYDE KDHLMTPEEA 

      1570       1580       1590       1600       1610       1620 
ATAEEARMHE MRCLEALGRW DELNSKSVVW ADQRGNRNDS VRDEINKKQL DHKMAVIAAR 

      1630       1640       1650       1660       1670       1680 
GAWAVDNWER MADYVSVISE NTQDGAMLRA VVAVHNDENT KAMGLIEKVR EMIDSELTAM 

      1690       1700       1710       1720       1730       1740 
ANESYERAYI PMVSVQQMAE LEEAIEYKTR PERRPRIALL WSRRLQGCRR NVEQWQRLIM 

      1750       1760       1770       1780       1790       1800 
LRGLVLSPQE MHPLRVKFSS MCRKQGKNSM SRAVLRELLS LPANSDLVRA KAPFDKPLLV 

      1810       1820       1830       1840       1850       1860 
LALAKQLYQD DHKDEAIRAL EDLANHWNKR INPIPKATGR ELIPPSTKEP ARICAKVLLK 

      1870       1880       1890       1900       1910       1920 
LGEWTELKSK TSNNMQVGEL SFVRQQVSPQ YRTKESRTPE TIAFENTINY YQQATQYDPG 

      1930       1940       1950       1960       1970       1980 
WHKVWHKLAS THFYAVCRER PHPTTVISPP QQPQQPKKMH IPPVTRATSP PPPAQKSPQP 

      1990       2000       2010       2020       2030       2040 
APFHSITEPL SVIIDYPVPP PLGSLVGLPP MPAYLSSNSS LPPQHHHVSP LSNDSPSNSA 

      2050       2060       2070       2080       2090       2100 
ENKLYLKHAA HAVRCFAKAL MCSPGSRLED TLRLMQLWFD HGDDKDQDVY FALTETIFDL 

      2110       2120       2130       2140       2150       2160 
PVTTWLEAIP QLMARLDCPD DQKSVQLVLR VLCEIARHRP QAVIYALTVA SRSKDVHRSK 

      2170       2180       2190       2200       2210       2220 
NAGTVLEKMM EYHSKLVREA SLVTEELVRC AILWHEQWHD ALDDASRVYF HRRLQDNNVQ 

      2230       2240       2250       2260       2270       2280 
AMFDALRNMN DLMQKGAPTT MKEHSFQQTY SSDLKEAGRY VQAFESSGNV KDLNQAWEIY 

      2290       2300       2310       2320       2330       2340 
CSVFKKLRDQ LATLNSLDLV YVSPNLVSAK DLELVVPGTY DPSAPIVSIQ SFSSKMNVIT 

      2350       2360       2370       2380       2390       2400 
SKQRPRKMVI RGSNGLDYQF LLKGHEDPRQ DERVMQLFGL VNTLLANNSE TCRRNLTIQR 

      2410       2420       2430       2440       2450       2460 
YSIVALSKDS GLIGWVPNCD TLHTLVKEYR EKKAKIPLSI EHKTLQKLSL ETEHLTLMQK 

      2470       2480       2490       2500       2510       2520 
LQLFESALSV TQGEDLRHVL WLKSPSSEVW FDRRTNYTRS VACMSMVGYI LGLGDRHPSN 

      2530       2540       2550       2560       2570       2580 
LMLDRLTGKV VHIDFGDCFE VAMLREKFPE RVPFRLTRML INAMEVTGLD GVYNYTAERV 

      2590       2600       2610       2620       2630       2640 
LKMLRTNQES LLAVLEAFVY DPVINWRLVE GMKKDPKTRK DTGGRQNMAG AVLPSSSTTD 

      2650       2660       2670       2680       2690 
SIMETIKRKL DGTEFVHTDG STPPEPLQVT EQLAMLTEQA TSPLNLCQSY IGWCPFW


References and documentation are available. 

Number of amino acids: 2697

Molecular weight: 306528.86

Theoretical pI: 8.57


Amino acid composition: 
Ala (A) 216	  8.0%
Arg (R) 172	  6.4%
Asn (N) 117	  4.3%
Asp (D) 143	  5.3%
Cys (C)  40	  1.5%
Gln (Q) 150	  5.6%
Glu (E) 166	  6.2%
Gly (G)  95	  3.5%
His (H)  66	  2.4%
Ile (I) 147	  5.5%
Leu (L) 290	 10.8%
Lys (K) 157	  5.8%
Met (M)  95	  3.5%
Phe (F)  81	  3.0%
Pro (P) 128	  4.7%
Ser (S) 194	  7.2%
Thr (T) 148	  5.5%
Trp (W)  35	  1.3%
Tyr (Y)  78	  2.9%
Val (V) 179	  6.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%



Total number of negatively charged residues (Asp + Glu): 309
Total number of positively charged residues (Arg + Lys): 329

Atomic composition:

Carbon      C	     13570
Hydrogen    H	     21712
Nitrogen    N	      3804
Oxygen      O	      4003
Sulfur      S	       135

Formula: C13570H21712N3804O4003S135
Total number of atoms: 43224

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   311220
Abs 0.1% (=1 g/l)   1.015, assuming all pairs of Cys residues form cystines


Ext. coefficient   308720
Abs 0.1% (=1 g/l)   1.007, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 47.22
This classifies the protein as unstable.



Aliphatic index: 90.45

Grand average of hydropathicity (GRAVY): -0.310