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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MLRSTISLLM NSAAQKTMTN SNFVLNAPKI TLTKVEQNIC NLLNDYTDLY NQKYHNKPEP

70 80 90 100 110 120
LTLRITGGWV RDKLLGQGSH DLDIAINVMS GEQFATGLNE YLQQHYAKYG AKPHNIHKID

130 140 150 160 170 180
KNPEKSKHLE TATTKLFGVE VDFVNLRSEK YTELSRIPKV CFGTPEEDAL RRDATLNALF

190 200 210 220 230 240
YNIHKGEVED FTKRGLQDLK DGVLRTPLPA KQTFLDDPLR VLRLIRFASR FNFTIDPEVM

250 260 270 280 290 300
AEMGDPQINV AFNSKISRER VGVEMEKILV GPTPLLALQL IQRAHLENVI FFWHNDSSVV

310 320 330 340 350 360
KFNEENCQDM DKINHVYNDN ILNSHLKSFI ELYPMFLEKL PILREKIGRS PGFQQNFILS

370 380 390 400 410 420
AILSPMANLQ IIGNPKKKIN NLVSVTESIV KEGLKLSKND AAVIAKTVDS ICSYEEILAK

430 440 450 460 470 480
FADRSQLKKS EIGIFLRNFN GEWETAHFAS LSDAFLKIPK LETKKIELLF QNYNEFYSYI

490 500 510 520 530 540
FDNNLNNCHE LKPIVDGKQM AKLLQMKPGP WLGKINNEAI RWQFDNPTGT DQELITHLKA


ILPKYL


References and documentation are available.

Number of amino acids: 546 Molecular weight: 62484.99 Theoretical pI: 8.32
Amino acid composition: 
Ala (A) 30 5.5% Arg (R) 21 3.8% Asn (N) 44 8.1% Asp (D) 28 5.1% Cys (C) 5 0.9% Gln (Q) 22 4.0% Glu (E) 37 6.8% Gly (G) 25 4.6% His (H) 14 2.6% Ile (I) 41 7.5% Leu (L) 65 11.9% Lys (K) 47 8.6% Met (M) 12 2.2% Phe (F) 28 5.1% Pro (P) 25 4.6% Ser (S) 29 5.3% Thr (T) 27 4.9% Trp (W) 5 0.9% Tyr (Y) 15 2.7% Val (V) 26 4.8% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 65 Total number of positively charged residues (Arg + Lys): 68 Atomic composition: Carbon C 2818 Hydrogen H 4459 Nitrogen N 755 Oxygen O 814 Sulfur S 17 Formula: C2818H4459N755O814S17 Total number of atoms: 8863 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 50100 Abs 0.1% (=1 g/l) 0.802, assuming all pairs of Cys residues form cystines Ext. coefficient 49850 Abs 0.1% (=1 g/l) 0.798, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 41.42 This classifies the protein as unstable. Aliphatic index: 95.02 Grand average of hydropathicity (GRAVY): -0.346