ProtParam
User-provided sequence:
10 20 30 40 50 60
MMSVRAINGC SIIRTATSAG GPPVSLFRHR IQRLRASHLR EFSKLRLNFP LIRADRRFLG
70 80 90 100 110 120
NSDAPSCSTC IHSLVESVSE ELESISRRKG SRMRVRASVK VKLTSYGEVL EDKLVNQELE
130 140 150 160 170 180
AGLLLEFKKD ADRVLLAVLH RRDGKKNWMV FDQNGVSCSI KPQQITYIVP NVYNFDHTGL
190 200 210 220 230 240
TDFLQRAQDN LDPQLLEFAW MELLEKNKPV TPEELAEMIY GRADPLESYC AHFLLSQDEI
250 260 270 280 290 300
YFSILESKGS RSIYSPRPTE QVEELLRRQR VKEAEDKEFQ EFIQLLKSAK KAPSHAKPPK
310 320 330 340 350 360
SSWLADDKVQ DRIGSLEAYA IDAWASTDQQ KLAGTILKSM GLQKTSVSAL NLLIDIGYFP
370 380 390 400 410 420
VHVNLELLKL NLPTHHSEAI TEAAEALLSE SSDIDAVRRI DLTHLKVYAI DVDEADELDD
430 440 450 460 470 480
ALSATRLQDG RIKIWIHVAD PARYVTPGSK VDREARRRGT SVFLPTATYP MFPEKLAMEG
490 500 510 520 530 540
MSLRQGENCN AVSVSVVLRS DGCITEYSVD NSIIRPTYML TYESASELLH LNLEEEAELK
550 560 570 580 590 600
LLSEAAFIRS QWRREQGAVD TTTLETRIKV VNPEDPEPLI NLYVENQADL AMRLVFEMMI
610 620 630 640 650 660
LCGEVVATFG SQHNIPLPYR GQPQSNIDVS AFAHLPEGPV RSSSIVKVMR AAEMNFRCPV
670 680 690 700 710 720
RHGVLGIPGY VQFTSPIRRY MDLTAHYQIK AFLRGGDNFP FSAGELEGIA ASVNMQSKVV
730 740 750 760 770 780
RKLSNTGLRY WVIEFLRRQE KGKKYTALVL RFVKDRIASL LLVEVGFQAT AWVSEGKQVG
790 800
DEIEVRVEEA HPRDDLILFK EVI
References and
documentation are available.
Number of amino acids: 803
Molecular weight: 90678.89
Theoretical pI: 6.20
Total number of negatively charged residues (Asp + Glu): 109
Total number of positively charged residues (Arg + Lys): 101
Atomic composition:
Carbon C 4028
Hydrogen H 6441
Nitrogen N 1125
Oxygen O 1199
Sulfur S 27
Formula: C
4028H
6441N
1125O
1199S
27
Total number of atoms: 12820
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 77280
Abs 0.1% (=1 g/l) 0.852, assuming all pairs of Cys residues form cystines
Ext. coefficient 76780
Abs 0.1% (=1 g/l) 0.847, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 42.82
This classifies the protein as unstable.
Aliphatic index: 95.44
Grand average of hydropathicity (GRAVY): -0.249