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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MNDDSQDKII HDIRIQLRKA ATELSRWKLY GSSKWAAEAL AGLAEAIDVD QTHSLADESP

70 80 90 100 110 120
LRNKQGVPKQ MFEIPQNGFG LSETEYDLYL LGSTLFDAKE FDRCVFFLKD VTNPYLKFLK

130 140 150 160 170 180
LYSKFLSWDK KSQESMENIL TTGKFTDEMY RANKDGDGSG NEDINQSGHQ RANLKMVSNE

190 200 210 220 230 240
HESQSNISSI LKEINTFLES YEIKIDDDEA DLGLALLYYL RGVILKQEKN ISKAMSSFLK

250 260 270 280 290 300
SLSCYSFNWS CWLELMDCLQ KVDDALLLNN YLYQNFQFKF SENLGSQRTI EFNIMIKFFK

310 320 330 340 350 360
LKVFEELNGQ LEDYFEDLEF LLQVFPNFTF LKAYNATISY NNLDYVTAES RFDDIVKQDP

370 380 390 400 410 420
YRLNDLETYS NILYVMQKNS KLAYLAQFVS QIDRFRPETC CIIANYYSAR QEHEKSIMYF

430 440 450 460 470 480
RRALTLDKKT TNAWTLMGHE FVELSNSHAA IECYRRAVDI CPRDFKAWFG LGQAYALLDM

490 500 510 520 530 540
HLYSLYYFQK ACTLKPWDRR IWQVLGECYS KTGNKVEAIK CYKRSIKASQ TVDQNTSIYY

550 560 570 580 590 600
RLAQLYEELE DLQECKKFMM KCVDVEELLE GIVTDETVKA RLWLAIFEIK AGNYQLAYDY

610 620
AMGVSSGTSQ EIEEARMLAR ECRRHM


References and documentation are available.

Number of amino acids: 626 Molecular weight: 73114.17 Theoretical pI: 5.29
Amino acid composition: 
Ala (A) 42 6.7% Arg (R) 28 4.5% Asn (N) 33 5.3% Asp (D) 41 6.5% Cys (C) 14 2.2% Gln (Q) 31 5.0% Glu (E) 50 8.0% Gly (G) 24 3.8% His (H) 9 1.4% Ile (I) 35 5.6% Leu (L) 71 11.3% Lys (K) 47 7.5% Met (M) 17 2.7% Phe (F) 34 5.4% Pro (P) 9 1.4% Ser (S) 46 7.3% Thr (T) 26 4.2% Trp (W) 10 1.6% Tyr (Y) 36 5.8% Val (V) 23 3.7% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 91 Total number of positively charged residues (Arg + Lys): 75 Atomic composition: Carbon C 3284 Hydrogen H 5049 Nitrogen N 849 Oxygen O 981 Sulfur S 31 Formula: C3284H5049N849O981S31 Total number of atoms: 10194 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 109515 Abs 0.1% (=1 g/l) 1.498, assuming all pairs of Cys residues form cystines Ext. coefficient 108640 Abs 0.1% (=1 g/l) 1.486, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 45.60 This classifies the protein as unstable. Aliphatic index: 83.40 Grand average of hydropathicity (GRAVY): -0.405