ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MNHLNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG RQGIVPGNRL 

        70         80         90        100        110        120 
KILVGMYDKK PAGPGSGPPA TPAQPQPGLH APAPPASQYT PMLPNTYQPQ PDSVYLVPTP 

       130        140        150        160        170        180 
SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ 

       190        200        210        220        230        240 
VPPSAGMGHD IYQVPPSMDT RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDTPRHL 

       250        260        270        280        290        300 
LAPGPQDIYD VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS 

       310        320        330        340        350        360 
NHHAVYDVPP SVSKDVPDGP LLREETYDVP PAFAKAKPFD PARTPLVLGA PPPDSPPAED 

       370        380        390        400        410        420 
VYYVPPPAPD LYDVPPGLRR PGPGTLYDVP RERVLPPEVA DGGVVDSGVY AVPPPAEREA 

       430        440        450        460        470        480 
PAEGKRLSAS STGSTRSSQS ASSLEVAGPG REPLELEVAV EALARLQQGV SATVAHLLDL 

       490        500        510        520        530        540 
AGSAGATGSW RSPSEPQEPL VQDLQAAVAA VQSAVHELLE FARSAVGNAA HTSDRALHAK 

       550        560        570        580        590        600 
LSRQLQKMED VHQTLVAHGQ ALDAGRGGSG ATLEDLDRLV ACSRAVPEDA KQLASFLHGN 

       610        620        630        640        650        660 
ASLLFRRTKA TAPGPEGGGT LHPNPTDKTS SIQSRPLPSP PKFTSQDSPD GQYENSEGGW 

       670        680        690        700        710        720 
MEDYDYVHLQ GKEEFEKTQK ELLEKGSITR QGKSQLELQQ LKQFERLEQE VSRPIDHDLA 

       730        740        750        760        770        780 
NWTPAQPLAP GRTGGLGPSD RQLLLFYLEQ CEANLTTLTN AVDAFFTAVA TNQPPKIFVA 

       790        800        810        820        830        840 
HSKFVILSAH KLVFIGDTLS RQAKAADVRS QVTHYSNLLC DLLRGIVATT KAAALQYPSP 

       850        860        870 
SAAQDMVERV KELGHSTQQF RRVLGQLAAA 

References and documentation are available.

Number of amino acids: 870

Molecular weight: 93383.84

Theoretical pI: 5.45

Amino acid composition: 
Ala (A)  87	 10.0%
Arg (R)  40	  4.6%
Asn (N)  16	  1.8%
Asp (D)  51	  5.9%
Cys (C)   4	  0.5%
Gln (Q)  59	  6.8%
Glu (E)  47	  5.4%
Gly (G)  68	  7.8%
His (H)  23	  2.6%
Ile (I)  13	  1.5%
Leu (L)  84	  9.7%
Lys (K)  34	  3.9%
Met (M)  10	  1.1%
Phe (F)  19	  2.2%
Pro (P) 106	 12.2%
Ser (S)  63	  7.2%
Thr (T)  45	  5.2%
Trp (W)   6	  0.7%
Tyr (Y)  29	  3.3%
Val (V)  66	  7.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 98
Total number of positively charged residues (Arg + Lys): 74

Atomic composition:

Carbon      C	      4148
Hydrogen    H	      6477
Nitrogen    N	      1151
Oxygen      O	      1279
Sulfur      S	        14

Formula: C4148H6477N1151O1279S14
Total number of atoms: 13069

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    76460
Abs 0.1% (=1 g/l)   0.819, assuming all pairs of Cys residues form cystines


Ext. coefficient    76210
Abs 0.1% (=1 g/l)   0.816, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 59.19
This classifies the protein as unstable.



Aliphatic index: 75.48

Grand average of hydropathicity (GRAVY): -0.483