ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MPGTPQKNKR SASISVSPAK KTEEKEIIQN DSKAILSKQT KRKKKYAFAP INNLNGKNTK 

        70         80         90        100        110        120 
VSNASVLKSI AVSQVRNTSR TKDINKAVSK SVKQLPNSQV KPKREMSNLS RHHDFTQDED 

       130        140        150        160        170        180 
GPMEEVIWKY SPLQRDMSDK TTSAAEYSDD YEDVQNPSST PIVPNRLKTV LSFTNIQVPN 

       190        200        210        220        230        240 
ADVNQLIQEN GNEQVRPKPA EISTRESLRN IDDILDDIEG DLTIKPTITK FSDLPSSPIK 

       250        260        270        280        290        300 
APNVEKKAEV NAEEVDKMDS TGDSNDGDDS LIDILTQKYV EKRKSESQIT IQGNTNQKSG 

       310        320        330        340        350        360 
AQESCGKNDN TKSRGEIEDH ENVDNQAKTG NAFYENEEDS NCQRIKKNEK IEYNSSDEFS 

       370        380        390        400        410        420 
DDSLIELLNE TQTQVEPNTI EQDLDKVEKM VSDDLRIATD STLSAYALRA KSGAPRDGVV 

       430        440        450        460        470        480 
RLVIVSLRSV ELPKIGTQKI LECIDGKGEQ SSVVVRHPWV YLEFEVGDVI HIIEGKNIEN 

       490        500        510        520        530        540 
KRLLSDDKNP KTQLANDNLL VLNPDVLFSA TSVGSSVGCL RRSILQMQFQ DPRGEPSLVM 

       550        560        570        580        590        600 
TLGNIVHELL QDSIKYKLSH NKISMEIIIQ KLDSLLETYS FSIIICNEEI QYVKELVMKE 

       610        620        630        640        650        660 
HAENILYFVN KFVSKSNYGC YTSISGTRRT QPISISNVID IEENIWSPIY GLKGFLDATV 

       670        680        690        700        710        720 
EANVENNKKH IVPLEVKTGK SRSVSYEVQG LIYTLLLNDR YEIPIEFFLL YFTRDKNMTK 

       730        740        750        760        770        780 
FPSVLHSIKH ILMSRNRMSM NFKHQLQEVF GQAQSRFELP PLLRDSSCDS CFIKESCMVL 

       790        800        810        820        830        840 
NKLLEDGTPE ESGLVEGEFE ILTNHLSQNL ANYKEFFTKY NDLITKEESS ITCVNKELFL 

       850        860        870        880        890        900 
LDGSTRESRS GRCLSGLVVS EVVEHEKTEG AYIYCFSRRR NDNNSQSMLS SQIAANDFVI 

       910        920        930        940        950        960 
ISDEEGHFCL CQGRVQFINP AKIGISVKRK LLNNRLLDKE KGVTTIQSVV ESELEQSSLI 

       970        980        990       1000       1010       1020 
ATQNLVTYRI DKNDIQQSLS LARFNLLSLF LPAVSPGVDI VDERSKLCRK TKRSDGGNEI 

      1030       1040       1050       1060       1070       1080 
LRSLLVDNRA PKFRDANDDP VIPYKLSKDT TLNLNQKEAI DKVMRAEDYA LILGMPGTGK 

      1090       1100       1110       1120       1130       1140 
TTVIAEIIKI LVSEGKRVLL TSYTHSAVDN ILIKLRNTNI SIMRLGMKHK VHPDTQKYVP 

      1150       1160       1170       1180       1190       1200 
NYASVKSYND YLSKINSTSV VATTCLGIND ILFTLNEKDF DYVILDEASQ ISMPVALGPL 

      1210       1220       1230       1240       1250       1260 
RYGNRFIMVG DHYQLPPLVK NDAARLGGLE ESLFKTFCEK HPESVAELTL QYRMCGDIVT 

      1270       1280       1290       1300       1310       1320 
LSNFLIYDNK LKCGNNEVFA QSLELPMPEA LSRYRNESAN SKQWLEDILE PTRKVVFLNY 

      1330       1340       1350       1360       1370       1380 
DNCPDIIEQS EKDNITNHGE AELTLQCVEG MLLSGVPCED IGVMTLYRAQ LRLLKKIFNK 

      1390       1400       1410       1420       1430       1440 
NVYDGLEILT ADQFQGRDKK CIIISMVRRN SQLNGGALLK ELRRVNVAMT RAKSKLIIIG 

      1450       1460       1470       1480       1490       1500 
SKSTIGSVPE IKSFVNLLEE RNWVYTMCKD ALYKYKFPDR SNAIDEARKG CGKRTGAKPI 

      1510       1520 
TSKSKFVSDK PIIKEILQEY ES 

References and documentation are available.

Number of amino acids: 1522

Molecular weight: 171694.43

Theoretical pI: 6.11

Amino acid composition: 
Ala (A)  64	  4.2%
Arg (R)  73	  4.8%
Asn (N) 105	  6.9%
Asp (D)  94	  6.2%
Cys (C)  25	  1.6%
Gln (Q)  62	  4.1%
Glu (E) 117	  7.7%
Gly (G)  70	  4.6%
His (H)  21	  1.4%
Ile (I) 117	  7.7%
Leu (L) 146	  9.6%
Lys (K) 126	  8.3%
Met (M)  29	  1.9%
Phe (F)  45	  3.0%
Pro (P)  57	  3.7%
Ser (S) 141	  9.3%
Thr (T)  78	  5.1%
Trp (W)   5	  0.3%
Tyr (Y)  45	  3.0%
Val (V) 102	  6.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 211
Total number of positively charged residues (Arg + Lys): 199

Atomic composition:

Carbon      C	      7536
Hydrogen    H	     12189
Nitrogen    N	      2081
Oxygen      O	      2376
Sulfur      S	        54

Formula: C7536H12189N2081O2376S54
Total number of atoms: 24236

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    96050
Abs 0.1% (=1 g/l)   0.559, assuming all pairs of Cys residues form cystines


Ext. coefficient    94550
Abs 0.1% (=1 g/l)   0.551, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 48.16
This classifies the protein as unstable.



Aliphatic index: 91.03

Grand average of hydropathicity (GRAVY): -0.454