ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MPNDNKTPNR SSTPKFTKKP VTPNDKIPER EEKSNEVKTP KIPLFTFAKS KNYSRPSTAI 

        70         80         90        100        110        120 
HTSPHQPSDV KPTSHKQLQQ PKSSPLKKNN YNSFPHSNLE KISNSKLLSL LRSKTSAGRI 

       130        140        150        160        170        180 
ESNNPSHDAS RSLASFEQTA FSRHAQQQTS TFNSKPVRTI VPISTSQTNN SFLSGVKSLL 

       190        200        210        220        230        240 
SEEKIRDYSK EILGINLANE QPVLEKPLKK GSADIGASVI SLTKDKSIRK DTVEEKKEEK 

       250        260        270        280        290        300 
LNIGKNFAHS DSLSVPKVSA GDSGISPEES KARSPGIAKP NAIQTEVYGI NEESTNERLE 

       310        320        330        340        350        360 
INQEKPVKLD ENSANSTVAS ALDTNGTSAT TETLTSKKIV PSPKKVAIDQ DKITLHDEKT 

       370        380        390        400        410        420 
LAPSKHQPIT SEQKMKEDAD LKRMEILKSP HLSKSPADRP QGRRNSRNFS TRDEETTKLA 

       430        440        450        460        470        480 
FLVEYEGQEN NYNSTSRSTE KKNDMNTSAK NKNGENKKIG KRPPEIMSTE AHVNKVTEET 

       490        500        510        520        530        540 
TKQIQSVRID GRKVLQKVQG ESHIDSRNNT LNVTPSKRPQ LGEIPNPMKK HKPNEGRTPN 

       550        560        570        580        590        600 
ISNGTINIQK KLEPKEIVRD ILHTKESSNE AKKTIQNPLN KSQNTALPST HKVTQKKDIK 

       610        620        630        640        650        660 
IGTNDLFQVE SAPKISSEID RENVKSKDEP VSKAVESKSL LNLFSNVLKA PFIKSESKPF 

       670        680        690        700        710        720 
SSDALSKEKA NFLETIASTE KPENKTDKVS LSQPVSASKH EYSDNFPVSL SQPSKKSFAN 

       730        740        750        760        770        780 
HTEDEQIEKK KICRGRMNTI ITHPGKMELV YVSDSDDSSS DNDSLTDLES LSSGESNEIK 

       790        800        810        820        830        840 
VTNDLDTSAE KDQIQAGKWF DPVLDWRKSD RELTKNILWR IADKTTYDKE TITDLIEQGI 

       850        860        870        880        890        900 
PKHSYLSGNP LTSVTNDICS VENYETSSAF FYQQVHKKDR LQYLPLYAVS TFENTNNTEK 

       910        920        930        940        950        960 
NDVTNKNINI GKHSQEQNSS SAKPSQIPTV SSPLGFEETK LSTTPTKSNR RVSHSDTNSS 

       970        980        990       1000       1010       1020 
KPKNTKENLS KSSWRQEWLA NLKLISVSLV DEFPSELSDS DRQIINEKMQ LLKDIFANNL 

      1030       1040       1050       1060       1070       1080 
KSAISNNFRE SDIIILKGEI EDYPMSSEIK IYYNELQNKP DAKKARFWSF MKTQRFVSNM 

      1090       1100       1110       1120       1130       1140 
GFDIQKSCEP VSISTSVKPH VVEPEHMADA KIMPKDILQI TKKPLMVKNV KPSSPPDVKS 

      1150       1160       1170       1180       1190       1200 
LVQLSTMETK TLPEKKQFDS IFNSNKAKII PGNGKHASEN ISLSFSRPAS YGYFSVGKRV 

      1210       1220       1230       1240       1250       1260 
PIVEDRRVKQ LDDITDSNTT EILTSVDVLG THSQTGTQQS NMYTSTQKTE LEIDNKDSVT 

      1270       1280       1290       1300       1310       1320 
ECSKDMKEDG LSFVDIVLSK AASALDEKEK QLAVANEIIR SLSDEVMRNE IRITSLQGDL 

      1330       1340       1350 
TFTKKCLENA RSQISEKDAK INKLMEKDFQ VNKEIKPY 

References and documentation are available.

Number of amino acids: 1358

Molecular weight: 152061.67

Theoretical pI: 9.03

Amino acid composition: 
Ala (A)  59	  4.3%
Arg (R)  48	  3.5%
Asn (N) 100	  7.4%
Asp (D)  77	  5.7%
Cys (C)   5	  0.4%
Gln (Q)  57	  4.2%
Glu (E) 108	  8.0%
Gly (G)  39	  2.9%
His (H)  26	  1.9%
Ile (I)  89	  6.6%
Leu (L)  92	  6.8%
Lys (K) 158	 11.6%
Met (M)  20	  1.5%
Phe (F)  37	  2.7%
Pro (P)  77	  5.7%
Ser (S) 174	 12.8%
Thr (T)  98	  7.2%
Trp (W)   6	  0.4%
Tyr (Y)  21	  1.5%
Val (V)  67	  4.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 185
Total number of positively charged residues (Arg + Lys): 206

Atomic composition:

Carbon      C	      6603
Hydrogen    H	     10741
Nitrogen    N	      1875
Oxygen      O	      2179
Sulfur      S	        25

Formula: C6603H10741N1875O2179S25
Total number of atoms: 21423

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    64540
Abs 0.1% (=1 g/l)   0.424, assuming all pairs of Cys residues form cystines


Ext. coefficient    64290
Abs 0.1% (=1 g/l)   0.423, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 46.85
This classifies the protein as unstable.



Aliphatic index: 70.63

Grand average of hydropathicity (GRAVY): -0.884