ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MQRPFLLAYL VLSLLFNSAL GFPTALVPRG SSEGTSCNSI VNGCPNLDFN WHMDQQNIMQ 

        70         80         90        100        110        120 
YTLDVTSVSW VQDNTYQITI HVKGKENIDL KYLWSLKIIG VTGPKGTVQL YGYNENTYLI 

       130        140        150        160        170        180 
DNPTDFTATF EVYATQDVNS CQVWMPNFQI QFEYLQGSAA QYASSWQWGT TSFDLSTGCN 

       190        200        210        220        230        240 
NYDNQGHSQT DFPGFYWNID CDNNCGGTKS STTTSSTSES STTTSSTSES STTTSSTSES 

       250        260        270        280        290        300 
STTTSSTSES STSSSTTAPA TPTTTSCTKE KPTPPTTTSC TKEKPTPPHH DTTPCTKKKT 

       310        320        330        340        350        360 
TTSKTCTKKT TTPVPTPSSS TTESSSAPVP TPSSSTTESS SAPVTSSTTE SSSAPVPTPS 

       370        380        390        400        410        420 
SSTTESSSAP VTSSTTESSS APVTSSTTES SSAPVPTPSS STTESSSAPV TSSTTESSSA 

       430        440        450        460        470        480 
PVTSSTTESS SAPVTSSTTE SSSAPVTSST TESSSAPVPT PSSSTTESSS APVTSSTTES 

       490        500        510        520        530        540 
SSAPVPTPSS STTESSSAPV TSSTTESSSA PVPTPSSSTT ESSSAPAPTP SSSTTESSSA 

       550        560        570        580        590        600 
PVTSSTTESS SAPVPTPSSS TTESSSTPVT SSTTESSSAP VPTPSSSTTE SSSAPVPTPS 

       610        620        630        640        650        660 
SSTTESSSAP APTPSSSTTE SSSAPVTSST TESSSAPVPT PSSSTTESSS APVPTPSSST 

       670        680        690        700        710        720 
TESSSAPVPT PSSSTTESSS APVTSSTTES SSAPVTSSTT ESSSAPVPTP SSSTTESSSA 

       730        740        750        760        770        780 
PVPTPSSSTT ESSSAPVPTP SSSTTESSSA PVTSSTTESS SAPVPTPSSS TTESSSAPVP 

       790        800        810        820        830        840 
TPSSSTTESS SAPVPTPSSS TTESSVAPVP TPSSSSNITS SAPSSTPFSS STESSSVPVP 

       850        860        870        880        890        900 
TPSSSTTESS SAPVSSSTTE SSVAPVPTPS SSSNITSSAP SSIPFSSTTE SFSTGTTVTP 

       910        920        930        940        950        960 
SSSKYPGSQT ETSVSSTTET TIVPTKTTTS VTTPSTTTIT TTVCSTGTNS AGETTSGCSP 

       970        980        990       1000       1010       1020 
KTVTTTVPTT TTTSVTTSST TTITTTVCST GTNSAGETTS GCSPKTITTT VPCSTSPSET 

      1030       1040       1050       1060       1070       1080 
ASESTTTSPT TPVTTVVSTT VVTTEYSTST KPGGEITTTF VTKNIPTTYL TTIAPTPSVT 

      1090       1100       1110       1120       1130       1140 
TVTNFTPTTI TTTVCSTGTN SAGETTSGCS PKTVTTTVPC STGTGEYTTE ATTLVTTAVT 

      1150       1160       1170       1180       1190       1200 
TTVVTTESST GTNSAGKTTT GYTTKSVPTT YVTTLAPSAP VTPATNAVPT TITTTECSAA 

      1210       1220       1230       1240       1250       1260 
TNAAGETTSV CSAKTIVSSA SAGENTAPSA TTPVTTAIPT TVITTESSVG TNSAGETTTG 

      1270       1280       1290       1300       1310       1320 
YTTKSIPTTY ITTLIPGSNG AKNYETVATA TNPISIKTTS QLATTASASS VAPVVTSPSL 

      1330       1340       1350       1360 
TGPLQSASGS AVATYSVPSI SSTYQGAANI KVLGNFMWLL LALPVVF 

References and documentation are available.

Number of amino acids: 1367

Molecular weight: 136110.54

Theoretical pI: 4.29

Amino acid composition: 
Ala (A)  87	  6.4%
Arg (R)   2	  0.1%
Asn (N)  36	  2.6%
Asp (D)  14	  1.0%
Cys (C)  20	  1.5%
Gln (Q)  20	  1.5%
Glu (E)  69	  5.0%
Gly (G)  45	  3.3%
His (H)   5	  0.4%
Ile (I)  32	  2.3%
Leu (L)  29	  2.1%
Lys (K)  30	  2.2%
Met (M)   5	  0.4%
Phe (F)  18	  1.3%
Pro (P) 143	 10.5%
Ser (S) 347	 25.4%
Thr (T) 338	 24.7%
Trp (W)   8	  0.6%
Tyr (Y)  23	  1.7%
Val (V)  96	  7.0%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 83
Total number of positively charged residues (Arg + Lys): 32

Atomic composition:

Carbon      C	      5714
Hydrogen    H	      9151
Nitrogen    N	      1477
Oxygen      O	      2298
Sulfur      S	        25

Formula: C5714H9151N1477O2298S25
Total number of atoms: 18665

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    79520
Abs 0.1% (=1 g/l)   0.584, assuming all pairs of Cys residues form cystines


Ext. coefficient    78270
Abs 0.1% (=1 g/l)   0.575, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 73.94
This classifies the protein as unstable.



Aliphatic index: 44.13

Grand average of hydropathicity (GRAVY): -0.368