ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSDEGADKSL DTNTEFIIQT RSRRSNAGNK LQKLLEQELR DIESTKRQIS SYKNGNDDEE 

        70         80         90        100        110        120 
DEIGLLFQED EDDEDFEMMA KDDDDEGEEK EDETQSIRKE PSQASSEQAA DDLMFSSSES 

       130        140        150        160        170        180 
EDSSNENDED AEEKEIRRQE LLSRKKRNKR LQKGPVVIKK QKPKPKSGEA IPRSHHTHEQ 

       190        200        210        220        230        240 
LNAETLLLNT RRTSKRSSVM ENTMKVYEKL SKAEKKRKII QERIRKHKEQ ESQHMLTQEE 

       250        260        270        280        290        300 
RLRIAKETEK LNILSLDKFK EQEVWKKENR LALQKRQKQK FQPNETILQF LSTAWLMTPA 

       310        320        330        340        350        360 
MELEDRKYWQ EQLNKRDKKK KKYPRKPKKN LNLGKQDASD DKKRESEESI KNDGDVNSLG 

       370        380        390        400        410        420 
ENSSSVHNQK RIEETSTNDT VEGESSPDAA VSRVNSDELK PTALPDVTLD AIANKQSTVD 

       430        440        450        460        470        480 
EAPNSQPQKN IITNEQKITN VGEPIQNLHN EEIKDEMVSA LESRENTFEN SSPAAQVVSQ 

       490        500        510        520        530        540 
RDNSATPTPS NSTGTEDTIL ISPDTDIKGE PEPCLKTEGI ENLSHNVPQE TKSNTDVSFL 

       550        560        570        580        590        600 
KQVTFTDHPQ VAIIDTEESP SKKDTANVDE SSAENSLSTQ TYEGPEQLTS RNFVTLYDFP 

       610        620        630        640        650        660 
NAPPNLKDFN TNLFGDRWSY TNGLSATQRP QDMKTVFHSI LPSPPQSSVP SPTVDISLDL 

       670        680        690        700        710        720 
SALANFPSFG EYDKKIVHQI NTEINKDLEI KIKTQPPTGV FLANGIRKKC LITNKECQYF 

       730        740        750        760        770        780 
DPRTGVPYSD VEAYKIIQRI QDPISKEEGR SDIKRDETTN EDSDDQVRFK WFGFKNGGIY 

       790 
LDLSQRPAKG VPEGF 

References and documentation are available.

Number of amino acids: 795

Molecular weight: 90580.07

Theoretical pI: 5.09

Amino acid composition: 
Ala (A)  35	  4.4%
Arg (R)  40	  5.0%
Asn (N)  52	  6.5%
Asp (D)  62	  7.8%
Cys (C)   3	  0.4%
Gln (Q)  48	  6.0%
Glu (E)  87	 10.9%
Gly (G)  28	  3.5%
His (H)  11	  1.4%
Ile (I)  44	  5.5%
Leu (L)  55	  6.9%
Lys (K)  78	  9.8%
Met (M)  11	  1.4%
Phe (F)  23	  2.9%
Pro (P)  42	  5.3%
Ser (S)  75	  9.4%
Thr (T)  53	  6.7%
Trp (W)   5	  0.6%
Tyr (Y)  12	  1.5%
Val (V)  31	  3.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 149
Total number of positively charged residues (Arg + Lys): 118

Atomic composition:

Carbon      C	      3896
Hydrogen    H	      6256
Nitrogen    N	      1120
Oxygen      O	      1334
Sulfur      S	        14

Formula: C3896H6256N1120O1334S14
Total number of atoms: 12620

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    45505
Abs 0.1% (=1 g/l)   0.502, assuming all pairs of Cys residues form cystines


Ext. coefficient    45380
Abs 0.1% (=1 g/l)   0.501, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 56.69
This classifies the protein as unstable.



Aliphatic index: 64.28

Grand average of hydropathicity (GRAVY): -1.124