ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSDLPPDLVE DILSRVPATS LKRLRFTCKQ WNSLFKNRRF TEKHFCKAPK QSHVLLWKDY 

        70         80         90        100        110        120 
TVCPMSINLN FSGSSIEFKS VLSLKDSHYN SEQVYIAKVF HCDGLLLCTT KDHRLLVWNP 

       130        140        150        160        170        180 
CLGETRWINF ENDYKPYSRF SLGYKNNKSC RSYKILRFWT SYLTPNHIGL RYNIYEFTTD 

       190        200        210        220        230        240 
SWRVLIDKVS LNYFLIESEN GVSFKGNTYW LALDEETNFL LGFDFTMERF KRLCLPSNKN 

       250        260        270        280        290        300 
CDTMVLSVVR EEKLSVSHQN FCSSKMDIWM TNRIDSETAM SWKRYFSVEF KILSMCHSLP 

       310        320        330        340        350        360 
FCNSFLIDEE KKIVISTVRG NENMVNIIGA YNAYYAEVPV ESTNWPCSPY FVSYVPSLVQ 

       370 
IQQCKSKENN KTSLEM 

References and documentation are available.

Number of amino acids: 376

Molecular weight: 44165.72

Theoretical pI: 8.63

Amino acid composition: 
Ala (A)   8	  2.1%
Arg (R)  18	  4.8%
Asn (N)  28	  7.4%
Asp (D)  16	  4.3%
Cys (C)  14	  3.7%
Gln (Q)   7	  1.9%
Glu (E)  23	  6.1%
Gly (G)  10	  2.7%
His (H)   8	  2.1%
Ile (I)  19	  5.1%
Leu (L)  37	  9.8%
Lys (K)  28	  7.4%
Met (M)  10	  2.7%
Phe (F)  23	  6.1%
Pro (P)  14	  3.7%
Ser (S)  41	 10.9%
Thr (T)  20	  5.3%
Trp (W)  10	  2.7%
Tyr (Y)  18	  4.8%
Val (V)  24	  6.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 39
Total number of positively charged residues (Arg + Lys): 46

Atomic composition:

Carbon      C	      1994
Hydrogen    H	      3049
Nitrogen    N	       519
Oxygen      O	       569
Sulfur      S	        24

Formula: C1994H3049N519O569S24
Total number of atoms: 6155

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    82695
Abs 0.1% (=1 g/l)   1.872, assuming all pairs of Cys residues form cystines


Ext. coefficient    81820
Abs 0.1% (=1 g/l)   1.853, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 49.16
This classifies the protein as unstable.



Aliphatic index: 78.72

Grand average of hydropathicity (GRAVY): -0.321