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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSECEQDTAS AAAPTSNHNE DGDNEEAGSE AAEFVSLPPP LEPEPIKQRH PKSQPTDEAP

70 80 90 100 110 120
PEPPPNEDEM PPPPPRIGSS QAGSSVLIMT PDEIIEAYER ALQEGQEEDG ETDGEKKKSG

130 140 150 160 170 180
WLNRPISVKS TLRAVRDGLL FVVGGFLRFV RRLDMHGGGT GNNINFVEGL IDFLAGSLGG

190 200 210 220 230 240
AAQVYVSQPL DTVKVKLQTF PEAYRGMLDC FLSTYRKDGV LRGLYAGSVP AVFANVAENS

250 260 270 280 290 300
VLFAAYGGCQ KFVAFCVGKE TAGDLTTVQN ACAGSLAACF STLTLCPTEL IKCKLQALRE

310 320 330 340 350 360
MKNFVEPAHP QDIRTPWTLT RYIWRTEGIR GFYRGLSSTF LREMPGYFFF FGSYEGTREL

370 380 390 400 410 420
LRRDDQSKDD IGPLRTMIAG AIGGVCLWTS TFPADVIKSR IQVKNLNESM FAVGADIVRR

430 440 450
EGVLALYRGL LPSVLRTIPA TATLFVVYEY TKRALSATL


References and documentation are available.

Number of amino acids: 459 Molecular weight: 50172.04 Theoretical pI: 5.21
Amino acid composition: 
Ala (A) 40 8.7% Arg (R) 29 6.3% Asn (N) 14 3.1% Asp (D) 22 4.8% Cys (C) 9 2.0% Gln (Q) 15 3.3% Glu (E) 35 7.6% Gly (G) 41 8.9% His (H) 4 0.9% Ile (I) 19 4.1% Leu (L) 43 9.4% Lys (K) 18 3.9% Met (M) 9 2.0% Phe (F) 23 5.0% Pro (P) 32 7.0% Ser (S) 29 6.3% Thr (T) 30 6.5% Trp (W) 4 0.9% Tyr (Y) 13 2.8% Val (V) 30 6.5% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 57 Total number of positively charged residues (Arg + Lys): 47 Atomic composition: Carbon C 2231 Hydrogen H 3497 Nitrogen N 605 Oxygen O 675 Sulfur S 18 Formula: C2231H3497N605O675S18 Total number of atoms: 7026 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 41870 Abs 0.1% (=1 g/l) 0.835, assuming all pairs of Cys residues form cystines Ext. coefficient 41370 Abs 0.1% (=1 g/l) 0.825, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 48.07 This classifies the protein as unstable. Aliphatic index: 80.35 Grand average of hydropathicity (GRAVY): -0.209