ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSEDMLQDVD PLETQEWVDA LQAVLEQEGP ERAHFLLEKL IDKARRNGTH LPYNATTAYL 

        70         80         90        100        110        120 
NTIPAGQEPH MPGNQEMERR IRAIIRWNAL AMVLRGSKKD LELGGHISSF ASSATIYDVC 

       130        140        150        160        170        180 
FNHFFRGPNE KDGGDLVYFQ GHIAPGIYAR SFLEGRLSED QLANFRQEVD GKGLSSYPHP 

       190        200        210        220        230        240 
KLMPDYWQFP TVSMGLGPIQ AIYQARFLKY LTDRGLKDCS AQTVYCFLGD GECDEPEALG 

       250        260        270        280        290        300 
AIGLAAREEL DNLVFIVNCN LQRLDGPVRG NGKIIQELEG EFRGAGWEVV KVIWGRYWDP 

       310        320        330        340        350        360 
LLARDTSGKL LQLMEETVDG EYQNCKAKGG AYTREHFFGK YPETAEMVAN MSDDDIWRLN 

       370        380        390        400        410        420 
RGGHDPVKVY AALDHAQKTK GRPTVILAKT VKGYGLGDAG EGKNIAHNVK KMGIESIRYF 

       430        440        450        460        470        480 
RDRFNIPIPD DQLEDLPFYH PGPDSEEVKY MMSRRAALHG SVPQRREKFS EELEVPSLKI 

       490        500        510        520        530        540 
FDSILQGSNG REISSTMAFV RVLTALLKDK KIGKNIVPII PDEARTFGME GLFRQVGIYA 

       550        560        570        580        590        600 
HEGQKYVPQD SDQVAYYRED KTGQVLQEGI NELGAMSSWV AAATSYSVND TPMIPFYIYY 

       610        620        630        640        650        660 
SMFGFQRIGD MAWAAGDMRA RGFLVGGTSG RTTLNGEGLQ HQDGHSHVLA NTIPNCITYD 

       670        680        690        700        710        720 
PTYGYEIAVV VQDGIRRMYG EKQEDIFYYL TTMNENYIQP EMPEGAEEGI VKGIYKLETV 

       730        740        750        760        770        780 
SGSGKGKVQL LSCGTILEQT RKAAQALAKD FGITADVFSV TSFNELTRDG QAVERWNMLH 

       790        800        810        820        830        840 
PTQTPKQAYI SQVISSDAPA IAATDYMKIY GEQLRAFMPT DYKVLGTDGF GRSDSRDNLR 

       850        860        870        880 
HHFEVDAKFI VIAALKSLVD RKELPVDVLA NAIKEYGIDA DKINPQYA 

References and documentation are available.

Number of amino acids: 888

Molecular weight: 99387.48

Theoretical pI: 5.39

Amino acid composition: 
Ala (A)  71	  8.0%
Arg (R)  50	  5.6%
Asn (N)  32	  3.6%
Asp (D)  59	  6.6%
Cys (C)   8	  0.9%
Gln (Q)  42	  4.7%
Glu (E)  63	  7.1%
Gly (G)  82	  9.2%
His (H)  20	  2.3%
Ile (I)  54	  6.1%
Leu (L)  71	  8.0%
Lys (K)  47	  5.3%
Met (M)  26	  2.9%
Phe (F)  35	  3.9%
Pro (P)  41	  4.6%
Ser (S)  43	  4.8%
Thr (T)  41	  4.6%
Trp (W)  10	  1.1%
Tyr (Y)  41	  4.6%
Val (V)  52	  5.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 122
Total number of positively charged residues (Arg + Lys): 97

Atomic composition:

Carbon      C	      4424
Hydrogen    H	      6861
Nitrogen    N	      1209
Oxygen      O	      1332
Sulfur      S	        34

Formula: C4424H6861N1209O1332S34
Total number of atoms: 13860

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   116590
Abs 0.1% (=1 g/l)   1.173, assuming all pairs of Cys residues form cystines


Ext. coefficient   116090
Abs 0.1% (=1 g/l)   1.168, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.91
This classifies the protein as stable.



Aliphatic index: 79.88

Grand average of hydropathicity (GRAVY): -0.401