ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSEKRSLPMV DVKIDDEDTP QLEKKIKRQS IDHGVGSEPV STIEIIPSDS FRKYNSQGFK 

        70         80         90        100        110        120 
AKDTDLMGTQ LESTFEQDVS QMEHDMADQE EHDLSSFERK KLPTDFDPSL YDISFQQIDA 

       130        140        150        160        170        180 
EQSVLNGIKD ENTSTVVRFF GVTSEGHSVL CNVTGFKNYL YVPAPNSSDA NDQEQINKFV 

       190        200        210        220        230        240 
HYLNETFDHA IDSIEVVSKQ SIWGYSGDTK LPFWKIYVTY PHMVNKLRTA FERGHLSFNS 

       250        260        270        280        290        300 
WFSNGTTTYD NIAYTLRLMV DCGIVGMSWI TLPKGKYSMI EPNNRVSSCQ LEVSINYRNL 

       310        320        330        340        350        360 
IAHPAEGDWS HTAPLRIMSF DIECAGRIGV FPEPEYDPVI QIANVVSIAG AKKPFIRNVF 

       370        380        390        400        410        420 
TLNTCSPITG SMIFSHATEE EMLSNWRNFI IKVDPDVIIG YNTTNFDIPY LLNRAKALKV 

       430        440        450        460        470        480 
NDFPYFGRLK TVKQEIKESV FSSKAYGTRE TKNVNIDGRL QLDLLQFIQR EYKLRSYTLN 

       490        500        510        520        530        540 
AVSAHFLGEQ KEDVHYSIIS DLQNGDSETR RRLAVYCLKD AYLPLRLMEK LMALVNYTEM 

       550        560        570        580        590        600 
ARVTGVPFSY LLARGQQIKV VSQLFRKCLE IDTVIPNMQS QASDDQYEGA TVIEPIRGYY 

       610        620        630        640        650        660 
DVPIATLDFN SLYPSIMMAH NLCYTTLCNK ATVERLNLKI DEDYVITPNG DYFVTTKRRR 

       670        680        690        700        710        720 
GILPIILDEL ISARKRAKKD LRDEKDPFKR DVLNGRQLAL KISANSVYGF TGATVGKLPC 

       730        740        750        760        770        780 
LAISSSVTAY GRTMILKTKT AVQEKYCIKN GYKHDAVVVY GDTDSVMVKF GTTDLKEAMD 

       790        800        810        820        830        840 
LGTEAAKYVS TLFKHPINLE FEKAYFPYLL INKKRYAGLF WTNPDKFDKL DQKGLASVRR 

       850        860        870        880        890        900 
DSCSLVSIVM NKVLKKILIE RNVDGALAFV RETINDILHN RVDISKLIIS KTLAPNYTNP 

       910        920        930        940        950        960 
QPHAVLAERM KRREGVGPNV GDRVDYVIIG GNDKLYNRAE DPLFVLENNI QVDSRYYLTN 

       970        980        990       1000       1010       1020 
QLQNPIISIV APIIGDKQAN GMFVVKSIKI NTGSQKGGLM SFIKKVEACK SCKGPLRKGE 

      1030       1040       1050       1060       1070       1080 
GPLCSNCLAR SGELYIKALY DVRDLEEKYS RLWTQCQRCA GNLHSEVLCS NKNCDIFYMR 

      1090 
VKVKKELQEK VEQLSKW 

References and documentation are available.

Number of amino acids: 1097

Molecular weight: 124590.74

Theoretical pI: 8.23

Amino acid composition: 
Ala (A)  58	  5.3%
Arg (R)  56	  5.1%
Asn (N)  62	  5.7%
Asp (D)  71	  6.5%
Cys (C)  20	  1.8%
Gln (Q)  40	  3.6%
Glu (E)  63	  5.7%
Gly (G)  59	  5.4%
His (H)  19	  1.7%
Ile (I)  79	  7.2%
Leu (L)  95	  8.7%
Lys (K)  84	  7.7%
Met (M)  26	  2.4%
Phe (F)  44	  4.0%
Pro (P)  44	  4.0%
Ser (S)  79	  7.2%
Thr (T)  60	  5.5%
Trp (W)   9	  0.8%
Tyr (Y)  49	  4.5%
Val (V)  80	  7.3%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 134
Total number of positively charged residues (Arg + Lys): 140

Atomic composition:

Carbon      C	      5560
Hydrogen    H	      8788
Nitrogen    N	      1498
Oxygen      O	      1656
Sulfur      S	        46

Formula: C5560H8788N1498O1656S46
Total number of atoms: 17548

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   123760
Abs 0.1% (=1 g/l)   0.993, assuming all pairs of Cys residues form cystines


Ext. coefficient   122510
Abs 0.1% (=1 g/l)   0.983, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 38.27
This classifies the protein as stable.



Aliphatic index: 88.30

Grand average of hydropathicity (GRAVY): -0.326