ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSENNSHNLD EHESHSENSD YMMDTQVEDD YDEDGHVQGE YSYYPDEDED EHMLSSVGSF 

        70         80         90        100        110        120 
EADDGEDDDN DYHHEDDSGL LYGYHRTQNG SDEDRNEEED GLERSHDNNE FGSNPLHLPD 

       130        140        150        160        170        180 
ILETFAQRLE QRRQTSEGLG QHPVGRTLPE ILSMIGGRME RSAESSARNE RISKLIENTG 

       190        200        210        220        230        240 
NASEDPYIAM ESLKELSENI LMMNQMVVDR IIPMETLIGN IAAILSDKIL REELELQMQA 

       250        260        270        280        290        300 
CRCMYNLFEV CPESISIAVD EHVIPILQGK LVEISYIDLA EQVLETVEYI SRVHGRDILK 

       310        320        330        340        350        360 
TGQLSIYVQF FDFLTIHAQR KAIAIVSNAC SSIRTDDFKT IVEVLPTLKP IFSNATDQPI 

       370        380        390        400        410        420 
LTRLVNAMYG ICGALHGVDK FETLFSLDLI ERIVQLVSIQ DTPLENKLKC LDILTVLAMS 

       430        440        450        460        470        480 
SDVLSRELRE KTDIVDMATR SFQHYSKSPN AGLHETLIYV PNSLLISISR FIVVLFPPED 

       490        500        510        520        530        540 
ERILSADKYT GNSDRGVISN QEKFDSLVQC LIPILVEIYT NAADFDVRRY VLIALLRVVS 

       550        560        570        580        590        600 
CINNSTAKAI NDQLIKLIGS ILAQKETASN ANGTYSSEAG TLLVGGLSLL DLICKKFSEL 

       610        620        630        640        650        660 
FFPSIKREGI FDLVKDLSVD FNNIDLKEDG NENISLSDEE GDLHSSIEEC DEGDEEYDYE 

       670        680        690        700        710        720 
FTDMEIPDSV KPKKISIHIF RTLSLAYIKN KGVNLVNRVL SQMNVEQEAI TEELHQIEGV 

       730        740        750        760        770        780 
VSILENPSTP DKTEEDWKGI WSVLKKCIFH EDFDVSGFEF TSTGLASSIT KRITSSTVSH 

       790        800        810        820        830        840 
FILAKSFLEV FEDCIDRFLE ILQSALTRLE NFSIVDCGLH DGGGVSSLAK EIKIKLVYDG 

       850        860        870        880        890        900 
DASKDNIGTD LSSTIVSVHC IASFTSLNEF LRHRMVRMRF LNSLIPNLTS SSTEADREEE 

       910        920        930        940        950        960 
ENCLDHMRKK NFDFFYDNEK VDMESTVFGV IFNTFVRRNR DLKTLWDDTH TIKFCKSLEG 

       970        980        990       1000       1010       1020 
NNRESEAAEE ANEGKKLRDF YKKREFAQVD TGSSADILTL LDFLHSCGVK SDSFINSKLS 

      1030       1040       1050       1060       1070       1080 
AKLARQLDEP LVVASGALPD WSLFLTRRFP FLFPFDTRML FLQCTSFGYG RLIQLWKNKS 

      1090       1100       1110       1120       1130       1140 
KGSKDLRNDE ALQQLGRITR RKLRISRKTI FATGLKILSK YGSSPDVLEI EYQEEAGTGL 

      1150       1160       1170       1180       1190       1200 
GPTLEFYSVV SKYFARKSLN MWRCNSYSYR SEMDVDTTDD YITTLLFPEP LNPFSNNEKV 

      1210       1220       1230       1240       1250       1260 
IELFGYLGTF VARSLLDNRI LDFRFSKVFF ELLHRMSTPN VTTVPSDVET CLLMIELVDP 

      1270       1280       1290       1300       1310       1320 
LLAKSLKYIV ANKDDNMTLE SLSLTFTVPG NDDIELIPGG CNKSLNSSNV EEYIHGVIDQ 

      1330       1340       1350       1360       1370       1380 
ILGKGIEKQL KAFIEGFSKV FSYERMLILF PDELVDIFGR VEEDWSMATL YTNLNAEHGY 

      1390       1400       1410       1420       1430       1440 
TMDSSIIHDF ISIISAFGKH ERRLFLQFLT GSPKLPIGGF KSLNPKFTVV LKHAEDGLTA 

      1450       1460       1470       1480 
DEYLPSVMTC ANYLKLPKYT SKDIMRSRLC QAIEEGAGAF LLS 

References and documentation are available.

Number of amino acids: 1483

Molecular weight: 167842.95

Theoretical pI: 4.78

Amino acid composition: 
Ala (A)  66	  4.5%
Arg (R)  71	  4.8%
Asn (N)  73	  4.9%
Asp (D) 112	  7.6%
Cys (C)  23	  1.6%
Gln (Q)  38	  2.6%
Glu (E) 128	  8.6%
Gly (G)  78	  5.3%
His (H)  34	  2.3%
Ile (I) 110	  7.4%
Leu (L) 167	 11.3%
Lys (K)  79	  5.3%
Met (M)  33	  2.2%
Phe (F)  77	  5.2%
Pro (P)  44	  3.0%
Ser (S) 139	  9.4%
Thr (T)  78	  5.3%
Trp (W)   7	  0.5%
Tyr (Y)  43	  2.9%
Val (V)  83	  5.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 240
Total number of positively charged residues (Arg + Lys): 150

Atomic composition:

Carbon      C	      7445
Hydrogen    H	     11707
Nitrogen    N	      1961
Oxygen      O	      2335
Sulfur      S	        56

Formula: C7445H11707N1961O2335S56
Total number of atoms: 23504

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   103945
Abs 0.1% (=1 g/l)   0.619, assuming all pairs of Cys residues form cystines


Ext. coefficient   102570
Abs 0.1% (=1 g/l)   0.611, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 41.16
This classifies the protein as unstable.



Aliphatic index: 93.53

Grand average of hydropathicity (GRAVY): -0.244