ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSFMDQIPGG GNYPKLPVEC LPNFPIQPSL TFRGRNDSHK LKNFISEIML NMSMISWPND 

        70         80         90        100        110        120 
ASRIVYCRRH LLNPAAQWAN DFVQEQGILE ITFDTFIQGL YQHFYKPPDI NKIFNAITQL 

       130        140        150        160        170        180 
SEAKLGIERL NQRFRKIWDR MPPDFMTEKA AIMTYTRLLT KETYNIVRMH KPETLKDAME 

       190        200        210        220        230        240 
EAYQTTALTE RFFPGFELDA DGDTIIGATT HLQEEYDSDY DSEDNLTQNR YVHTVRTRRS 

       250        260        270        280        290        300 
YNKPMSNHRN RRNNNASREE CIKNRLCFYC KKEGHRLNEC RARKRVLTDL ELESKDQQTL 

       310        320        330        340        350        360 
FIKTLPIVHY IAIPEMDNTA EKTIKIQNTK VKTLFDSGSP TSFIRRDIVE LLKYEIYETP 

       370        380        390        400        410        420 
PLRFRGFVAT KSAVTSEAVT IDLKINDLQI TLAAYILDNM DYQLLIGNPI LRRYPKILHT 

       430        440        450        460        470        480 
VLNTRESPDS LKPKTYRSET VNNVRTYSAG NRGNPRNIKL SFAPTILEAT DPKSAGNRGN 

       490        500        510        520        530        540 
PRNTKLSLAP TILEATDPKS AGNRGDSRTK TLSLATTTPA AIDPLTTLDN PGSTQSTFAQ 

       550        560        570        580        590        600 
FPIPEEASIL EEDGKYSNVV STIQSVEPNA TDHSNKDTFC TLPVWLQQKY REIIRNDLPP 

       610        620        630        640        650        660 
RPADINNIPV KHDIEIKPGA RLPRLQPYHV TEKNEQEINK IVQKLLDNKF IVPSKSPCSS 

       670        680        690        700        710        720 
PVVLVPKKDG TFRLCVDYRT LNKATISDPF PLPRIDNLLS RIGNAQIFTT LDLHSGYHQI 

       730        740        750        760        770        780 
PMEPKDRYKT AFVTPSGKYE YTVMPFGLVN APSTFARYMA DTFRDLRFVN VYLDDILIFS 

       790        800        810        820        830        840 
ESPEEHWKHL DTVLERLKNE NLIVKKKKCK FASEETEFLG YSIGIQKIAP LQHKCAAIRD 

       850        860        870        880        890        900 
FPTPKTVKQA QRFLGMINYY RRFIPNCSKI AQPIQLFICD KSQWTEKQDK AIEKLKAALC 

       910        920        930        940        950        960 
NSPVLVPFNN KANYRLTTDA SKDGIGAVLE EVDNKNKLVG VVGYFSKSLE SAQKNYPAGE 

       970        980        990       1000       1010       1020 
LELLGIIKAL HHFRYMLHGK HFTLRTDHIS LLSLQNKNEP ARRVQRWLDD LATYDFTLEY 

      1030       1040       1050       1060       1070       1080 
LAGPKNVVAD AISRAIYTIT PETSRPIDTE SWKSYYKSDP LCSAVLIHMK ELTQHNVTPE 

      1090       1100       1110       1120       1130       1140 
DMSAFRSYQK KLELSETFRK NYSLEDEMIY YQDRLVVPIK QQNAVMRLYH DHTLFGGHFG 

      1150       1160       1170       1180       1190       1200 
VTVTLAKISP IYYWPKLQHS IIQYIRTCVQ CQLIKSHRPR LHGLLQPLPI AEGRWLDISM 

      1210       1220       1230       1240       1250       1260 
DFVTGLPPTS NNLNMILVVV DRFSKRAHFI ATRKTLDATQ LIDLLFRYIF SYHGFPRTIT 

      1270       1280       1290       1300       1310       1320 
SDRDVRMTAD KYQELTKRLG IKSTMSSANH PQTDGQSERT IQTLNRLLRA YVSTNIQNWH 

      1330       1340       1350       1360       1370       1380 
VYLPQIEFVY NSTPTRTLGK SPFEIDLGYL PNTPAIKSDD EVNARSFTAV ELAKHLKALT 

      1390       1400       1410       1420       1430       1440 
IQTKEQLEHA QIEMETNNNQ RRKPLLLNIG DHVLVHRDAY FKKGAYMKVQ QIYVGPFRVV 

      1450       1460       1470       1480       1490 
KKINDNAYEL DLNSHKKKHR VINVQFLKSL YTVQTRTQRI NQSAPLRELR EHTKLLHS 

References and documentation are available.

Number of amino acids: 1498

Molecular weight: 172454.60

Theoretical pI: 9.26

Amino acid composition: 
Ala (A)  85	  5.7%
Arg (R)  96	  6.4%
Asn (N)  88	  5.9%
Asp (D)  82	  5.5%
Cys (C)  17	  1.1%
Gln (Q)  65	  4.3%
Glu (E)  83	  5.5%
Gly (G)  53	  3.5%
His (H)  43	  2.9%
Ile (I) 106	  7.1%
Leu (L) 146	  9.7%
Lys (K) 107	  7.1%
Met (M)  28	  1.9%
Phe (F)  61	  4.1%
Pro (P)  89	  5.9%
Ser (S)  89	  5.9%
Thr (T) 114	  7.6%
Trp (W)  11	  0.7%
Tyr (Y)  62	  4.1%
Val (V)  73	  4.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 165
Total number of positively charged residues (Arg + Lys): 203

Atomic composition:

Carbon      C	      7721
Hydrogen    H	     12211
Nitrogen    N	      2143
Oxygen      O	      2247
Sulfur      S	        45

Formula: C7721H12211N2143O2247S45
Total number of atoms: 24367

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   153880
Abs 0.1% (=1 g/l)   0.892, assuming all pairs of Cys residues form cystines


Ext. coefficient   152880
Abs 0.1% (=1 g/l)   0.886, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 43.23
This classifies the protein as unstable.



Aliphatic index: 85.41

Grand average of hydropathicity (GRAVY): -0.499