ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSGSLSRGNG GKKVLNKNQL LKRNRIRNAR SIRAEAVAAS STKTGTPSDL SESGSKLNVD 

        70         80         90        100        110        120 
QFISSRQFEV KQLQLAMHNS KAASSTRIFQ ALPRKLRRRT ASHNVRRIPK RMRNRALREM 

       130        140        150        160        170        180 
RKSDQQDVLK GSSASSRKAH GLNAKQLYKA RMSIKLLRLA SKSTSMKLSM PPEVTSSNCH 

       190        200        210        220        230        240 
VRQKIKTLKR MIKESSTANP NIKLLNNRMG SYDCTGVNEL APIPKGRVKY TKRQKHFAWL 

       250        260        270        280        290        300 
PTHIWNAKRS HMMKRWGYQM VWAPTQKCFK LTHRLGGDTC SSDGALCMDS SYIGTIIVKD 

       310        320        330        340        350        360 
KSNDSEGDFL KSIIGKLTAE RANLRKYREG QVLFQGLIYS FNEENGEDST KPLGPCDVFW 

       370        380        390        400        410        420 
VQKDTAIIRL HPSIYTQVFN ILLQHKEKLT VQDCRYSLAS VTLKGAKALE SLASCLRSTE 

       430        440        450        460        470        480 
YSKSFEQFKM VSMITDHNAL PQRCTFAFEA IDPRHLAAPK KLNDSQRKTV NSDDILSLHE 

       490        500        510        520        530        540 
NYPQDEINAV FNELCDPESR TQSYNNQNTL KEISARRYKL LTATPNSINK TTVPFKESDD 

       550        560        570        580        590        600 
PSIPLVIIRR LKTRDWIVVL PWFWLLPLWH LLNRIPRMYH IGLRQFQQIQ YENKQLYFPD 

       610        620        630        640        650        660 
DYPFTQLGYI ENSFYKKEAS KTKWDRKPMG KRINFEKIKD IHNTKLPAYS GEIGDFFSSD 

       670        680        690        700        710        720 
WRFLQILRNG IDYLQRNDKT LELMDSKKTG QFNAQGVRDI NCVNDVLEFC KDYEAKTKAM 

       730        740        750        760        770        780 
SLSIEENIPV ALCKNRKCQF RTPDSISVNS SSFSLTFFPR CIIAVSCTLL ERGHPKDNAR 

       790        800        810        820        830        840 
IYQVPEKDLE HWLQLAKGVY RPNGRKDHDL KIPLPEVHDL IGFITSGTYH LNCGNGMGIG 

       850        860        870 
FIDHHAAIRQ PTRYVLIRNV GTNTYRLGEW SKISV 

References and documentation are available.

Number of amino acids: 875

Molecular weight: 100395.40

Theoretical pI: 9.83

Amino acid composition: 
Ala (A)  48	  5.5%
Arg (R)  65	  7.4%
Asn (N)  52	  5.9%
Asp (D)  44	  5.0%
Cys (C)  17	  1.9%
Gln (Q)  39	  4.5%
Glu (E)  39	  4.5%
Gly (G)  42	  4.8%
His (H)  23	  2.6%
Ile (I)  56	  6.4%
Leu (L)  82	  9.4%
Lys (K)  76	  8.7%
Met (M)  20	  2.3%
Phe (F)  33	  3.8%
Pro (P)  38	  4.3%
Ser (S)  77	  8.8%
Thr (T)  47	  5.4%
Trp (W)  13	  1.5%
Tyr (Y)  27	  3.1%
Val (V)  37	  4.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 83
Total number of positively charged residues (Arg + Lys): 141

Atomic composition:

Carbon      C	      4442
Hydrogen    H	      7104
Nitrogen    N	      1296
Oxygen      O	      1284
Sulfur      S	        37

Formula: C4442H7104N1296O1284S37
Total number of atoms: 14163

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   112730
Abs 0.1% (=1 g/l)   1.123, assuming all pairs of Cys residues form cystines


Ext. coefficient   111730
Abs 0.1% (=1 g/l)   1.113, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 42.83
This classifies the protein as unstable.



Aliphatic index: 79.26

Grand average of hydropathicity (GRAVY): -0.585