ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSIDEAVARY RDVIGNLATG NLRRIVIQSE KLAQIIASSK GTVRFHHKTR SGKTVIYKCI 

        70         80         90        100        110        120 
KKALLSSVAS LSSEFSSETD VQQFLHLNYI YQSHFQALSG QINKYCGMKK YYELKFAAID 

       130        140        150        160        170        180 
YLETEVQTTG LTLSRFWVAS LDEFIKKERW PDNGSNFQIF YKLMAEYSSW KWDSDDKRQL 

       190        200        210        220        230        240 
QFMYEFRMKL KECLVKFYEN FDLQKSSDPL KELIIPWEKI VYVANCIDAF TGEQVRIDGA 

       250        260        270        280        290        300 
ELIWTSKNLV FSSISSAVLR LNDLQNMFSA FRPYGEEALV QDFAHIRSLK WDSNDKVESL 

       310        320        330        340        350        360 
IRALIFNDMF PYFNKEQVDT KADGIFFLRL LRKNFKEHIN DVKDFHIQVI KYLNSQFKNN 

       370        380        390        400        410        420 
YSTLMTSSKT QDRRKSHNMP SSILDDGNKI GMHVSPIDEY SHFIDNDEPL WRDKVYPKIY 

       430        440        450        460        470        480 
TNEQTPTPDA SAIFDSHKIY AIISLLRYYL PEKRKFFRIY YLPSIFKRIL YYGAKFAQLY 

       490        500        510        520        530        540 
FMEGCLERLV IESLQILEPS LVHAINNLIK SSIESLKNVT VTSDDKTSSG VIILSYKEFK 

       550        560        570        580        590        600 
SLSEVNKDFN EPFWPNQSIA NSWPDFANKQ LKRGQILQDA FAFHLFEIEL PIIIDTTRNT 

       610        620        630        640        650        660 
HLKLVSNMCT TSILYLYNEV DSLSLTSIQE KLAVLPTSKR NEILLYNLNR LTKLKLLLLK 

       670        680 
ENEKGQKFYA FNFKYKRDGQ KTSLIRLI 

References and documentation are available.

Number of amino acids: 688

Molecular weight: 80426.47

Theoretical pI: 8.97

Amino acid composition: 
Ala (A)  33	  4.8%
Arg (R)  31	  4.5%
Asn (N)  39	  5.7%
Asp (D)  39	  5.7%
Cys (C)   6	  0.9%
Gln (Q)  29	  4.2%
Glu (E)  41	  6.0%
Gly (G)  20	  2.9%
His (H)  14	  2.0%
Ile (I)  57	  8.3%
Leu (L)  75	 10.9%
Lys (K)  61	  8.9%
Met (M)  12	  1.7%
Phe (F)  43	  6.2%
Pro (P)  19	  2.8%
Ser (S)  64	  9.3%
Thr (T)  30	  4.4%
Trp (W)  10	  1.5%
Tyr (Y)  34	  4.9%
Val (V)  31	  4.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 80
Total number of positively charged residues (Arg + Lys): 92

Atomic composition:

Carbon      C	      3672
Hydrogen    H	      5702
Nitrogen    N	       948
Oxygen      O	      1045
Sulfur      S	        18

Formula: C3672H5702N948O1045S18
Total number of atoms: 11385

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   106035
Abs 0.1% (=1 g/l)   1.318, assuming all pairs of Cys residues form cystines


Ext. coefficient   105660
Abs 0.1% (=1 g/l)   1.314, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 40.98
This classifies the protein as unstable.



Aliphatic index: 92.69

Grand average of hydropathicity (GRAVY): -0.312