ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSLISALQTT DVESVQTSPE QITERKAVRV STLQESLHSS EMHRAAPETP RSISNSVHKL 

        70         80         90        100        110        120 
KTIYSTYQQS GQPLSKEAIF RAKQKYGILN TPANYKTLGL GDSKSESVDL AARLASKRTK 

       130        140        150        160        170        180 
VSPDDCVETA IEQKARGEAF KVTFSKIPLT PPEDVPITVN LGLKGRRDFL TRLAAQKALA 

       190        200        210        220        230        240 
FSPSLDNSMK GTSDSSSVKK KRFSGAPIGN EFDANLVNPQ HPAGFKSLDL SKVLDGAERR 

       250        260        270        280        290        300 
AISRVNDRLY PQKVNFKNGL QSSDQSGVSK ANKEVFKKGT LEKLEHSAEQ FLESHAGNER 

       310        320        330        340        350        360 
QRLSDQQYMC AKGAADAVKD LDPKTLEDPD FAAREAQKKL YIKQVASPVV LNEAQKLANR 

       370        380        390        400        410        420 
KLQDIDSRDT YMLLFGNQAY NKLAVNIALQ HYSVKQEEKK KIYLGGGLWM TPEEVNAVAK 

       430        440        450        460        470        480 
KLISPVVNEI DERASRQRDV DKDIERRSRV LDQEYEDGNS MERAKEQNDG QLLLAMASKQ 

       490        500        510        520        530        540 
QQEKEAKKAE EGQRYDQFVQ KMNIKLQQKE KELENARENR ENLRNELQER LSKNLSGEND 

       550        560        570        580        590        600 
ELNDWNDACE RDLKNSSIEH YYAVRSHFDN LGNSERGYDE LLEERSKIQV EIERLVASIA 

       610        620        630        640        650        660 
EHKTAIHGFG ETADAGGAIP AVQKQKIPTR KDLLDATVND PLVISAEMAK EEAEMATEEC 

       670        680        690        700        710        720 
MLKELQVDEM IIIRNIMLRE CEKKLEEEKE TAKRSRRGTE ESKNNSNFSR DVIMSTPDNN 

       730        740        750        760        770        780 
EKVTPIGKSA SPKDVVKSRF LSTYNTGKDI DSSASARSIT GVSGVLDDGP KTPTSNKENE 

       790        800        810        820        830        840 
LIDDEVKSYK VHQAVDGTGE DSIANKRDKS SRPAANSGGS ITIEQFLFNK NADKQGLSKT 

       850        860        870        880        890        900 
ESVTMKREPV VDQMDSKKGH DFTHCNDNGR RSFSGFSQGS IENDYSNEVT DDQDDQEGSE 

       910        920 
IRVRDSNDSN TSPKESFFKE VI 

References and documentation are available.

Number of amino acids: 922

Molecular weight: 103143.95

Theoretical pI: 5.81

Amino acid composition: 
Ala (A)  70	  7.6%
Arg (R)  54	  5.9%
Asn (N)  54	  5.9%
Asp (D)  66	  7.2%
Cys (C)   6	  0.7%
Gln (Q)  49	  5.3%
Glu (E)  87	  9.4%
Gly (G)  47	  5.1%
His (H)  14	  1.5%
Ile (I)  42	  4.6%
Leu (L)  69	  7.5%
Lys (K)  86	  9.3%
Met (M)  17	  1.8%
Phe (F)  25	  2.7%
Pro (P)  31	  3.4%
Ser (S)  89	  9.7%
Thr (T)  42	  4.6%
Trp (W)   2	  0.2%
Tyr (Y)  19	  2.1%
Val (V)  53	  5.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 153
Total number of positively charged residues (Arg + Lys): 140

Atomic composition:

Carbon      C	      4430
Hydrogen    H	      7179
Nitrogen    N	      1303
Oxygen      O	      1482
Sulfur      S	        23

Formula: C4430H7179N1303O1482S23
Total number of atoms: 14417

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    39685
Abs 0.1% (=1 g/l)   0.385, assuming all pairs of Cys residues form cystines


Ext. coefficient    39310
Abs 0.1% (=1 g/l)   0.381, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 53.06
This classifies the protein as unstable.



Aliphatic index: 71.21

Grand average of hydropathicity (GRAVY): -0.865