ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSLPVTPVKS KVCSTLSIQH EMDHDQCRDV LCPRENLLAI NRTNNIESVA IPRQRSSKNK 

        70         80         90        100        110        120 
KPHEHTQSQV RFSIPDPNEI SQDSPLKIVF PKSGNETERR MSTSSLLMNS HGHLVDMHSK 

       130        140        150        160        170        180 
ILVDVPKEVW KFHHNRRKKC ESRHRKTRSD VRSNTSSSGK EPNHSRSKSL QSIIVDTMNT 

       190        200        210        220        230        240 
YRATEVETSI NENTSNISQV SPLNLSFDRP PPLTPEKNLY LTPESPLNRY HLPVPLEISL 

       250        260        270        280        290        300 
PPYLSPQNKD KKRSSLVYDG DGYSQFQEGN TSSSTESSLE QPSSSYSDED DSIPYAHHDV 

       310        320        330        340        350        360 
SFELNNADAD KLLGIDENAN VNLKIQRRNL KNPQHIKSKT DRECEEKNTE KNVSLKILST 

       370        380        390        400        410        420 
PNKLIDIPDL EHMKSPPSTG LNGTLKFFQQ FEPSEEPTSP TRQVNPESLD KLDMSFKFPS 

       430        440        450        460        470        480 
STTNNNVDKV HENRNSGDTN NEDFLKVDTS PVNQSFESRR QMLIDLQKSP TNNNPRIHKH 

       490        500        510        520        530        540 
RRSRSVHNID DISLNFEATS TPPAPTSAPS IPVEHSNPCT SIEIPKRSPL RFTSSPKTSD 

       550        560        570        580        590        600 
IPPEAQSPKN GSFLQEISVP SIQIIPDESI SHTREPSPSL IECPEDENEA FSTEVADHSI 

       610        620        630        640        650        660 
AIISETKSVP SIEPFKPLSS FNSFGQEIQN KEPTPLNQTP TDLIGKQRNC VNPHSIPFSV 

       670        680        690        700        710        720 
LSSNSQSSQS GSSKSSYNSE FSSNTAITDT TSQPSVTINR STLEHNFIEE KRSIKNLGHG 

       730        740        750        760        770        780 
PPSQKNNYSF PRNKNTPSNR HDLDFNTIYE KRDGKMVEVI LLDEDEDVGL KNNDISRTRV 

       790        800        810        820        830        840 
CHAQKAKNEQ QKKRLSHCNE ILGMCDKTAD DAKRIIYQLV NEKHKFSEKG QQTKPKKSRV 

       850        860        870 
LPPLPFPLYD EKGNSLIPNK YQSSIHNDIP SHRKLK 

References and documentation are available.

Number of amino acids: 876

Molecular weight: 98811.90

Theoretical pI: 7.21

Amino acid composition: 
Ala (A)  19	  2.2%
Arg (R)  45	  5.1%
Asn (N)  73	  8.3%
Asp (D)  50	  5.7%
Cys (C)  11	  1.3%
Gln (Q)  38	  4.3%
Glu (E)  63	  7.2%
Gly (G)  21	  2.4%
His (H)  32	  3.7%
Ile (I)  54	  6.2%
Leu (L)  61	  7.0%
Lys (K)  67	  7.6%
Met (M)  11	  1.3%
Phe (F)  27	  3.1%
Pro (P)  75	  8.6%
Ser (S) 123	 14.0%
Thr (T)  52	  5.9%
Trp (W)   1	  0.1%
Tyr (Y)  14	  1.6%
Val (V)  39	  4.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 113
Total number of positively charged residues (Arg + Lys): 112

Atomic composition:

Carbon      C	      4265
Hydrogen    H	      6814
Nitrogen    N	      1254
Oxygen      O	      1403
Sulfur      S	        22

Formula: C4265H6814N1254O1403S22
Total number of atoms: 13758

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    26985
Abs 0.1% (=1 g/l)   0.273, assuming all pairs of Cys residues form cystines


Ext. coefficient    26360
Abs 0.1% (=1 g/l)   0.267, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 65.65
This classifies the protein as unstable.



Aliphatic index: 66.28

Grand average of hydropathicity (GRAVY): -0.954