ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSNHSEAYGS RDQRREKYTQ GKEFEDGTLE TLESIISAVE DETLSKDYQP LIVFFQRGFG 

        70         80         90        100        110        120 
AQLVQTWSYY AQVNNHGKFS KTTSLLTKTL RVLSSDTSTV TIGSGLIRLI LTDYTKVLYR 

       130        140        150        160        170        180 
GLNNMRAQLT NPILRLLKQI VNFNNGQHIE ELVSYFDFSL PILPRLLVPS KSELANGNSS 

       190        200        210        220        230        240 
ADSSKHDSLR FTFIKFWLTL ISNASPFVRK ELLTENFKIM SNLFKFMNKA DSDKLSEHIL 

       250        260        270        280        290        300 
SVFINDILKE KSFKRTTKTK ILNELAASKI HHFYYSSNKN LVKKANEFFL TFGASRDFSV 

       310        320        330        340        350        360 
AFPDNCVWFK NSVADGASHG APITVNQVEF QIHNKLLFNT LRLFKPWEDT LQLGTLIKIL 

       370        380        390        400        410        420 
ENVPELVAPY SIFLTTNGNY DPKMTSYWFG ITLLINKIIN LKIPQFMEKV DSNIPPATSL 

       430        440        450        460        470        480 
VIENILPSLL TKSSLVKSLQ FETPIIRQLA CQSIVLALKK LEKVSTFYDQ KGWRNEKTIL 

       490        500        510        520        530        540 
LNEFHTRIPD LPIFVSTLSN SLASNKDNRI LPLSISIIFN YYSKMFPNLF SINLPSSNIY 

       550        560        570        580        590        600 
TDIMQKSKIS GIEFAILDNY LQFQEFNSTQ TRWWNPSSGG NSLFTLLLKL ASSKNASNVI 

       610        620        630        640        650        660 
TTRISNLLDE LTRTNVIFNI SLISPVMALV NSLQGLSLQV SEIDNMEQVW KWFDETISRV 

       670        680        690        700        710        720 
VKTPYKYVDM AKEYNYISPF IMCLSEQWKY VDKSGNPEFL IKWLILFLRN MIFIGEDHIG 

       730        740        750        760        770        780 
IDKLVKNVFP EVSDHDVNIY LKLDSFEENI KKTNSSNSLI SSMKSSSFFQ YISALPSKNL 

       790        800        810        820        830        840 
MNISRLPVNK LDAAGILFRV QLLVEDDSVV YDNWFEATAC ELTGKIASYM VTDTEFPIIK 

       850        860        870        880        890        900 
VLERYINFAL PKLAIEKRNA LLMKKSRFMC NLIGAVCFET GHQLVEFREI IQKVVFSGEN 

       910        920        930        940        950        960 
VEEYANYNEL YQKEDVNAFL TSVSEYLSTS ALTSLLMCST KLESTRNILQ KLFNEGKTIK 

       970        980        990       1000       1010       1020 
ISLVKNILNK AANEDPASIK EVNISLAKFF EENKVCVDAS SDPMGKLSLS ETTSLINSFV 

      1030       1040       1050       1060       1070       1080 
SSDLNYLVLK AFYRWEHFSF PSFIPSIWRI KDSPLLSIVT TAALFKHMQD KDFSAFAHET 

      1090       1100       1110       1120       1130       1140 
ISKYGNEIAK STYTTSKSEI FDEILNMITT YIDFYDETKR NEILKCVLSQ SDHKYHAATV 

      1150       1160       1170       1180       1190       1200 
RYIAAHNNFT YPGVETWLHK TLLYLTKYLS ERKVISNSFF ELLRAMAELL KLEEVPNKLN 

      1210       1220       1230       1240       1250       1260 
VKIINSQLEA ILGSEWIKQI KVLEYVIVLI FCVSKKSIQS QRMVQLLLSN DSYSSIMIKD 

      1270       1280       1290       1300       1310       1320 
NDEDSSYRKF LSTMILFSLF SIDPVVNSTP IVQEKLLTFY SGTISSNDKL ILKILETIES 

      1330       1340       1350       1360       1370       1380 
HTATSWTNMI FSWEFIKDEE EEILEAIGDT RLITKEREGL ILTLQKNMIK KSIDRYVLER 

      1390       1400       1410       1420       1430       1440 
PQVPELYTDS NTNNYDATTR CDLVKKYYDD TERSGVDMYD PLFLLLLIIH NKELVKMVKD 

      1450       1460       1470       1480       1490       1500 
DEGNVTYRYE FENFLDCKIF QFIICSLSDC HTVANISYEH LSNLASSLEK KTAQMNLEKQ 

      1510       1520       1530       1540       1550       1560 
ITSKDNERKE SDSDLIKYNS IYQVLIKRIL YQRQQNQDPI NPLIWFSISR IVDLLGSPTA 

      1570       1580       1590       1600       1610       1620 
PLHEKAYRWV LSNSTIRSWD IPMVSDVMMS YNKRQQDDNK KEIDMEIYYG ELSWVLTTIC 

      1630       1640       1650       1660       1670       1680 
KGIKTDEDYK MLEKKGVFEW LLNLINMPYL KERLRELIYF IFYKVQRVAD DGGLNLISRN 

      1690       1700       1710       1720       1730       1740 
GIVSFFEVLN NNIKSRLPQD DILNNIGTLR NENRGTLNTT LRLAQEQNGI EKLLLGYNEL 

      1750       1760 
VKSQKRLILW TEGDSDNVVK RLRK 

References and documentation are available.

Number of amino acids: 1764

Molecular weight: 203286.99

Theoretical pI: 6.97

Amino acid composition: 
Ala (A)  68	  3.9%
Arg (R)  64	  3.6%
Asn (N) 126	  7.1%
Asp (D)  88	  5.0%
Cys (C)  15	  0.9%
Gln (Q)  57	  3.2%
Glu (E) 117	  6.6%
Gly (G)  52	  2.9%
His (H)  25	  1.4%
Ile (I) 152	  8.6%
Leu (L) 211	 12.0%
Lys (K) 139	  7.9%
Met (M)  37	  2.1%
Phe (F)  94	  5.3%
Pro (P)  51	  2.9%
Ser (S) 173	  9.8%
Thr (T) 105	  6.0%
Trp (W)  25	  1.4%
Tyr (Y)  68	  3.9%
Val (V)  97	  5.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 205
Total number of positively charged residues (Arg + Lys): 203

Atomic composition:

Carbon      C	      9222
Hydrogen    H	     14519
Nitrogen    N	      2353
Oxygen      O	      2704
Sulfur      S	        52

Formula: C9222H14519N2353O2704S52
Total number of atoms: 28850

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   239695
Abs 0.1% (=1 g/l)   1.179, assuming all pairs of Cys residues form cystines


Ext. coefficient   238820
Abs 0.1% (=1 g/l)   1.175, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 39.67
This classifies the protein as stable.



Aliphatic index: 100.06

Grand average of hydropathicity (GRAVY): -0.174