ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSQTITSLDP NCVIVFNKTS SANEKSLNVE FKRLNIHSII EPGHDLQTSY AFIRIHQDNA 

        70         80         90        100        110        120 
KPLFSFLQNL DFIESIIPYH DTELSDDLHK LISISKSKIL EAPKQYELYN LSNLTNNPKQ 

       130        140        150        160        170        180 
SLYFAFLQNY IKWLIPFSFF GLSIRFLSNF TYEFNSTYSL FAILWTLSFT AFWLYKYEPF 

       190        200        210        220        230        240 
WSDRLSKYSS FSTIEFLQDK QKAQKKASSV IMLKKCCFIP VALLFGAILL SFQLYCFALE 

       250        260        270        280        290        300 
IFIKQIYNGP MISILSFLPT ILICTFTPVL TVIYNKYFVE PMTKWENHSS VVNAKKSKEA 

       310        320        330        340        350        360 
KNFVIIFLSS YVPLLITLFL YLPMGHLLTA EIRTKVFNAF SILARLPTHD SDFIIDTKRY 

       370        380        390        400        410        420 
EDQFFYFIVI NQLIQFSMEN FVPSLVSIAQ QKINGPNPNF VKAESEIGKA QLSSSDMKIW 

       430        440        450        460        470        480 
SKVKSYQTDP WGATFDLDAN FKKLLLQFGY LVMFSTIWPL APFICLIVNL IVYQVDLRKA 

       490        500        510        520        530        540 
VLYSKPEYFP FPIYDKPSSV SNTQKLTVGL WNSVLVMFSI LGCVITATLT YMYQSCNIPG 

       550        560        570        580        590        600 
VGAHTSIHTN KAWYLANPIN HSWINIVLYA VFIEHVSVAI FFLFSSILKS SHDDVANGIV 

       610        620        630        640        650        660 
PKHVVNVQNP PKQEVFEKIP SPEFNSNNEK ELVQRKGSAN EKLHQELGEK QPASSANGYE 

       670        680        690        700        710        720 
AHAATHANND PSSLSSASSP SLSSSSSSSK TGVVKAVDND TAGSAGKKPL ATESTEKRNS 

       730        740        750        760        770        780 
LVKVPTVGSY GVAGATLPET IPTSKNYYLR FDEDGKSIRD AKSSAESSNA TNNNTLGTES 

       790        800        810        820        830        840 
KLLPDGDAVD ALSRKIDQIP KIAVTGGENN ENTQAKDDAA TKTPLIKDAN IKPVVNAAVN 

       850        860        870        880        890        900 
DNQSKVSVAT EQTKKTEVST KNGPSRSIST KETKDSARPS NNNTTTTTTT DATQPHHHHH 

       910        920        930        940 
HHRHRDAGVK NVTNNSKTTE SSSSSSAAKE KPKHKKGLLH KLKKKL 

References and documentation are available.

Number of amino acids: 946

Molecular weight: 105853.86

Theoretical pI: 9.06

Amino acid composition: 
Ala (A)  63	  6.7%
Arg (R)  17	  1.8%
Asn (N)  65	  6.9%
Asp (D)  38	  4.0%
Cys (C)   8	  0.8%
Gln (Q)  33	  3.5%
Glu (E)  43	  4.5%
Gly (G)  31	  3.3%
His (H)  27	  2.9%
Ile (I)  68	  7.2%
Leu (L)  86	  9.1%
Lys (K)  81	  8.6%
Met (M)  10	  1.1%
Phe (F)  55	  5.8%
Pro (P)  48	  5.1%
Ser (S) 108	 11.4%
Thr (T)  64	  6.8%
Trp (W)  11	  1.2%
Tyr (Y)  33	  3.5%
Val (V)  57	  6.0%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 81
Total number of positively charged residues (Arg + Lys): 98

Atomic composition:

Carbon      C	      4809
Hydrogen    H	      7483
Nitrogen    N	      1241
Oxygen      O	      1412
Sulfur      S	        18

Formula: C4809H7483N1241O1412S18
Total number of atoms: 14963

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   110170
Abs 0.1% (=1 g/l)   1.041, assuming all pairs of Cys residues form cystines


Ext. coefficient   109670
Abs 0.1% (=1 g/l)   1.036, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.68
This classifies the protein as stable.



Aliphatic index: 87.62

Grand average of hydropathicity (GRAVY): -0.211