ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSRKRSTKPK PAAKIALKKE NDQFLEALKL YEGKQYKKSL KLLDAILKKD GSHVDSLALK 

        70         80         90        100        110        120 
GLDLYSVGEK DDAASYVANA IRKIEGASAS PICCHVLGIY MRNTKEYKES IKWFTAALNN 

       130        140        150        160        170        180 
GSTNKQIYRD LATLQSQIGD FKNALVSRKK YWEAFLGYRA NWTSLAVAQD VNGERQQAIN 

       190        200        210        220        230        240 
TLSQFEKLAE GKISDSEKYE HSECLMYKND IMYKAASDNQ DKLQNVLKHL NDIEPCVFDK 

       250        260        270        280        290        300 
FGLLERKATI YMKLGQLKDA SIVYRTLIKR NPDNFKYYKL LEVSLGIQGD NKLKKALYGK 

       310        320        330        340        350        360 
LEQFYPRCEP PKFIPLTFLQ DKEELSKKLR EYVLPQLERG VPATFSNVKP LYQRRKSKVS 

       370        380        390        400        410        420 
PLLEKIVLDY LSGLDPTQDP IPFIWTNYYL SQHFLFLKDF PKAQEYIDAA LDHTPTLVEF 

       430        440        450        460        470        480 
YILKARILKH LGLMDTAAGI LEEGRQLDLQ DRFINCKTVK YFLRANNIDK AVEVASLFTK 

       490        500        510        520        530        540 
NDDSVNGIKD LHLVEASWFI VEQAEAYYRL YLDRKKKLDD LASLKKEVES DKSEQIANDI 

       550        560        570        580        590        600 
KENQWLVRKY KGLALKRFNA IPKFYKQFED DQLDFHSYCM RKGTPRAYLE MLEWGKALYT 

       610        620        630        640        650        660 
KPMYVRAMKE ASKLYFQMHD DRLKRKSDSL DENSDEIQNN GQNSSSQKKK AKKEAAAMNK 

       670        680        690        700        710        720 
RKETEAKSVA AYPSDQDNDV FGEKLIETST PMEDFATEFY NNYSMQVRED ERDYILDFEF 

       730        740        750        760        770        780 
NYRIGKLALC FASLNKFAKR FGTTSGLFGS MAIVLLHATR NDTPFDPILK KVVTKSLEKE 

       790        800        810        820        830        840 
YSENFPLNEI SNNSFDWLNF YQEKFGKNDI NGLLFLYRYR DDVPIGSSNL KEMIISSLSP 

       850 
LEPHSQNEIL QYYL 

References and documentation are available.

Number of amino acids: 854

Molecular weight: 98905.22

Theoretical pI: 8.86

Amino acid composition: 
Ala (A)  61	  7.1%
Arg (R)  37	  4.3%
Asn (N)  47	  5.5%
Asp (D)  59	  6.9%
Cys (C)   8	  0.9%
Gln (Q)  36	  4.2%
Glu (E)  60	  7.0%
Gly (G)  34	  4.0%
His (H)  12	  1.4%
Ile (I)  44	  5.2%
Leu (L)  99	 11.6%
Lys (K)  96	 11.2%
Met (M)  16	  1.9%
Phe (F)  41	  4.8%
Pro (P)  29	  3.4%
Ser (S)  58	  6.8%
Thr (T)  29	  3.4%
Trp (W)   8	  0.9%
Tyr (Y)  47	  5.5%
Val (V)  33	  3.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 119
Total number of positively charged residues (Arg + Lys): 133

Atomic composition:

Carbon      C	      4467
Hydrogen    H	      6996
Nitrogen    N	      1176
Oxygen      O	      1310
Sulfur      S	        24

Formula: C4467H6996N1176O1310S24
Total number of atoms: 13973

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   114530
Abs 0.1% (=1 g/l)   1.158, assuming all pairs of Cys residues form cystines


Ext. coefficient   114030
Abs 0.1% (=1 g/l)   1.153, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 30.16
This classifies the protein as stable.



Aliphatic index: 83.65

Grand average of hydropathicity (GRAVY): -0.578