ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSRLSLLGLT AAVVLLSSFC QDRIHVDAAA ACKGCAPPCV CPGTKGERGN PGFGGEPGHP 

        70         80         90        100        110        120 
GAPGQDGPEG APGAPGMFGA EGDFGDMGSK GARGDRGLPG SPGHPGLQGL DGLPGLKGEE 

       130        140        150        160        170        180 
GIPGCNGTDG FPGMPGLAGP PGQSGQNGNP GRPGLSGPPG EGGVNSQGRK GVKGESGRSG 

       190        200        210        220        230        240 
VPGLPGNSGY PGLKGAKGDP GPYGLPGFPG VSGLKGRMGV RTSGVKGEKG LPGPPGPPGQ 

       250        260        270        280        290        300 
PGSYPWASKP IEMEVLQGPV GPAGVKGEKG RDGPVGPPGM LGLDGPPGYP GLKGQKGDLG 

       310        320        330        340        350        360 
DAGQRGKRGK DGVPGNYGEK GSQGEQGLGG TPGYPGTKGG AGEPGYPGRP GFEGDCGPEG 

       370        380        390        400        410        420 
PLGEGTGEAG PHGAQGFDGV QGGKGLPGHD GLPGPVGPRG PVGAPGAPGQ PGIDGMPGYT 

       430        440        450        460        470        480 
EKGDRGEDGY PGFAGEPGLP GEPGDCGYPG EDGLPGYDIQ GPPGLDGQSG RDGFPGIPGD 

       490        500        510        520        530        540 
IGDPGYSGEK GFPGTGVNKV GPPGMTGLPG EPGMPGRIGV DGYPGPPGNN GERGEDCGYC 

       550        560        570        580        590        600 
PDGVPGNAGD PGFPGMNGYP GPPGPNGDHG DCGMPGAPGK PRSAGSDGLS GSPGLPGIPG 

       610        620        630        640        650        660 
YPGMKGEAGE IVGPMENPAG IPGLKGDHGL PGLPGRPGSD GLPGYPGGPG QNGFPGLQGE 

       670        680        690        700        710        720 
PGLAGIDGKR GRQGSLGIPG LQGPPGDSFP GQPGTPGYKG ERGADGLPGL PGAQGPRGIP 

       730        740        750        760        770        780 
APLRIVNQVA GQPGVDGMPG LPGDRGADGL PGLPGPVGPD GYPGTPGERG MDGLPGFPGL 

       790        800        810        820        830        840 
HGEPGMRGQQ GEVGFNGIDG DCGEPGLDGY PGAPGAPGAP GETGFGFPGQ VGYPGPNGDA 

       850        860        870        880        890        900 
GAAGLPGPDG YPGRDGLPGT PGYPGEAGMN GQDGAPGQPG SRGESGLVGI DGKKGRDGTP 

       910        920        930        940        950        960 
GTRGQDGGPG YSGEAGAPGQ NGMDGYPGAP GDQGYPGSPG QDGYPGPSGI PGEDGLVGFP 

       970        980        990       1000       1010       1020 
GLRGEHGDNG LPGLEGECGE EGSRGLDGVP GYPGEHGTDG LPGLPGADGQ PGFVGEAGEP 

      1030       1040       1050       1060       1070       1080 
GTPGYRGQPG EPGNLAYPGQ PGDVGYPGPD GPPGLPGQDG LPGLNGERGD NGDSYPGNPG 

      1090       1100       1110       1120       1130       1140 
LSGQPGDAGY DGLDGVPGPP GYPGITGMPG LKGESGLPGL PGRQGNDGIP GQPGLEGECG 

      1150       1160       1170       1180       1190       1200 
EDGFPGSPGQ PGYPGQQGRE GEKGYPGIPG ENGLPGLRGQ DGQPGLKGEN GLDGQPGYPG 

      1210       1220       1230       1240       1250       1260 
SAGQLGTPGD VGYPGAPGEN GDNGNQGRDG QPGLRGESGQ PGQPGLPGRD GQPGPVGPPG 

      1270       1280       1290       1300       1310       1320 
DDGYPGAPGQ DIYGPPGQAG QDGYPGLDGL PGAPGLNGEP GSPGQYGMPG LPGGPGESGL 

      1330       1340       1350       1360       1370       1380 
PGYPGERGLP GLDGKRGHDG LPGAPGVPGV EGVPGLEGDC GEDGYPGAPG APGSNGYPGE 

      1390       1400       1410       1420       1430       1440 
RGLPGVPGQQ GRSGDNGYPG APGQPGIKGP RGDDGFPGRD GLDGLPGRPG REGLPGPMAM 

      1450       1460       1470       1480       1490       1500 
AVRNPPGQPG ENGYPGEKGY PGLPGDNGLS GPPGKAGYPG APGTDGYPGP PGLSGMPGHG 

      1510       1520       1530       1540       1550       1560 
GDQGFQGAAG RTGNPGLPGT PGYPGSPGGW APSRGFTFAK HSQTTAVPQC PPGASQLWEG 

      1570       1580       1590       1600       1610       1620 
YSLLYVQGNG RASGQDLGQP GSCLSKFNTM PFMFCNMNSV CHVSSRNDYS FWLSTDEPMT 

      1630       1640       1650       1660       1670       1680 
PMMNPVTGTA IRPYISRCAV CEVPTQIIAV HSQDTSVPQC PQGWSGMWTG YSFVMHTAAG 

      1690       1700       1710       1720       1730       1740 
AEGTGQSLQS PGSCLEEFRA VPFIECHGRG TCNYYATNHG FWLSIVDQDK QFRKPMSQTL 

      1750 
KAGGLKDRVS RCQVCLKNR 

References and documentation are available.

Number of amino acids: 1759

Molecular weight: 171086.22

Theoretical pI: 4.61

Amino acid composition: 
Ala (A)  78	  4.4%
Arg (R)  64	  3.6%
Asn (N)  47	  2.7%
Asp (D) 102	  5.8%
Cys (C)  27	  1.5%
Gln (Q)  79	  4.5%
Glu (E)  79	  4.5%
Gly (G) 510	 29.0%
His (H)  18	  1.0%
Ile (I)  29	  1.6%
Leu (L) 106	  6.0%
Lys (K)  45	  2.6%
Met (M)  33	  1.9%
Phe (F)  34	  1.9%
Pro (P) 280	 15.9%
Ser (S)  68	  3.9%
Thr (T)  39	  2.2%
Trp (W)   7	  0.4%
Tyr (Y)  58	  3.3%
Val (V)  56	  3.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 181
Total number of positively charged residues (Arg + Lys): 109

Atomic composition:

Carbon      C	      7403
Hydrogen    H	     11225
Nitrogen    N	      2165
Oxygen      O	      2413
Sulfur      S	        60

Formula: C7403H11225N2165O2413S60
Total number of atoms: 23266

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   126545
Abs 0.1% (=1 g/l)   0.740, assuming all pairs of Cys residues form cystines


Ext. coefficient   124920
Abs 0.1% (=1 g/l)   0.730, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 30.93
This classifies the protein as stable.



Aliphatic index: 43.60

Grand average of hydropathicity (GRAVY): -0.726