ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSSSKKLAGL RDNFSLLGEK NKILVANRGE IPIRIFRSAH ELSMRTIAIY SHEDRLSMHR 

        70         80         90        100        110        120 
LKADEAYVIG EEGQYTPVGA YLAMDEIIEI AKKHKVDFIH PGYGFLSENS EFADKVVKAG 

       130        140        150        160        170        180 
ITWIGPPAEV IDSVGDKVSA RHLAARANVP TVPGTPGPIE TVQEALDFVN EYGYPVIIKA 

       190        200        210        220        230        240 
AFGGGGRGMR VVREGDDVAD AFQRATSEAR TAFGNGTCFV ERFLDKPKHI EVQLLADNHG 

       250        260        270        280        290        300 
NVVHLFERDC SVQRRHQKVV EVAPAKTLPR EVRDAILTDA VKLAKVCGYR NAGTAEFLVD 

       310        320        330        340        350        360 
NQNRHYFIEI NPRIQVEHTI TEEITGIDIV SAQIQIAAGA TLTQLGLLQD KITTRGFSIQ 

       370        380        390        400        410        420 
CRITTEDPSK NFQPDTGRLE VYRSAGGNGV RLDGGNAYAG ATISPHYDSM LVKCSCSGST 

       430        440        450        460        470        480 
YEIVRRKMIR ALIEFRIRGV KTNIPFLLTL LTNPVFIEGT YWTTFIDDTP QLFQMVSSQN 

       490        500        510        520        530        540 
RAQKLLHYLA DLAVNGSSIK GQIGLPKLKS NPSVPHLHDA QGNVINVTKS APPSGWRQVL 

       550        560        570        580        590        600 
LEKGPSEFAK QVRQFNGTLL MDTTWRDAHQ SLLATRVRTH DLATIAPTTA HALAGAFALE 

       610        620        630        640        650        660 
CWGGATFDVA MRFLHEDPWE RLRKLRSLVP NIPFQMLLRG ANGVAYSSLP DNAIDHFVKQ 

       670        680        690        700        710        720 
AKDNGVDIFR VFDALNDLEQ LKVGVNAVKK AGGVVEATVC YSGDMLQPGK KYNLDYYLEV 

       730        740        750        760        770        780 
VEKIVQMGTH ILGIKDMAGT MKPAAAKLLI GSLRTRYPDL PIHVHSHDSA GTAVASMTAC 

       790        800        810        820        830        840 
ALAGADVVDV AINSMSGLTS QPSINALLAS LEGNIDTGIN VEHVRELDAY WAEMRLLYSC 

       850        860        870        880        890        900 
FEADLKGPDP EVYQHEIPGG QLTNLLFQAQ QLGLGEQWAE TKRAYREANY LLGDIVKVTP 

       910        920        930        940        950        960 
TSKVVGDLAQ FMVSNKLTSD DIRRLANSLD FPDSVMDFFE GLIGQPYGGF PEPLRSDVLR 

       970        980        990       1000       1010       1020 
NKRRKLTCRP GLELEPFDLE KIREDLQNRF GDIDECDVAS YNMYPRVYED FQKIRETYGD 

      1030       1040       1050       1060       1070       1080 
LSVLPTKNFL APAEPDEEIE VTIEQGKTLI IKLQAVGDLN KKTGQREVYF ELNGELRKIR 

      1090       1100       1110       1120       1130       1140 
VADKSQNIQS VAKPKADVHD THQIGAPMAG VIIEVKVHKG SLVKKGESIA VLSAMKMEMV 

      1150       1160       1170       1180 
VSSPADGQVK DVFIKDGESV DASDLLVVLE EETLPPSQKK 

References and documentation are available.

Number of amino acids: 1180

Molecular weight: 130166.68

Theoretical pI: 6.06

Amino acid composition: 
Ala (A) 102	  8.6%
Arg (R)  65	  5.5%
Asn (N)  46	  3.9%
Asp (D)  75	  6.4%
Cys (C)  12	  1.0%
Gln (Q)  48	  4.1%
Glu (E)  75	  6.4%
Gly (G)  90	  7.6%
His (H)  30	  2.5%
Ile (I)  73	  6.2%
Leu (L) 109	  9.2%
Lys (K)  69	  5.8%
Met (M)  25	  2.1%
Phe (F)  43	  3.6%
Pro (P)  55	  4.7%
Ser (S)  65	  5.5%
Thr (T)  62	  5.3%
Trp (W)   8	  0.7%
Tyr (Y)  32	  2.7%
Val (V)  96	  8.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 150
Total number of positively charged residues (Arg + Lys): 134

Atomic composition:

Carbon      C	      5783
Hydrogen    H	      9210
Nitrogen    N	      1606
Oxygen      O	      1734
Sulfur      S	        37

Formula: C5783H9210N1606O1734S37
Total number of atoms: 18370

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    92430
Abs 0.1% (=1 g/l)   0.710, assuming all pairs of Cys residues form cystines


Ext. coefficient    91680
Abs 0.1% (=1 g/l)   0.704, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 34.15
This classifies the protein as stable.



Aliphatic index: 92.39

Grand average of hydropathicity (GRAVY): -0.214