ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSTEEQNGVP LQRGSEFIAD DVTSNKSNNT RRMLVKEYRK IGRGAFGTVV QAYLTQDKKN 

        70         80         90        100        110        120 
WLGPFAIKKV PAHTEYKSRE LQILRIADHP NIVKLQYFFT HLSPQDNKVY QHLAMECLPE 

       130        140        150        160        170        180 
TLQIEINRYV TNKLEMPLKH IRLYTYQIAR GMLYLHGLGV CHRDIKPSNV LVDPETGVLK 

       190        200        210        220        230        240 
ICDFGSAKKL EHNQPSISYI CSRFYRAPEL IIGCTQYTTQ IDIWGLGCVM GEMLIGKAIF 

       250        260        270        280        290        300 
QGQEPLLQLR EIAKLLGPPD KRFIFFSNPA YDGPLFSKPL FSGSSQQRFE KYFGHSGPDG 

       310        320        330        340        350        360 
IDLLMKILVY EPQQRLSPRR ILAHQFFNEL RNDDTFLPRG FTEPIKLPNL FDFNDFELQI 

       370 
LGEFADKIKP TKVAE 

References and documentation are available.

Number of amino acids: 375

Molecular weight: 43135.85

Theoretical pI: 8.83

Amino acid composition: 
Ala (A)  16	  4.3%
Arg (R)  21	  5.6%
Asn (N)  16	  4.3%
Asp (D)  18	  4.8%
Cys (C)   6	  1.6%
Gln (Q)  22	  5.9%
Glu (E)  23	  6.1%
Gly (G)  25	  6.7%
His (H)  10	  2.7%
Ile (I)  28	  7.5%
Leu (L)  41	 10.9%
Lys (K)  26	  6.9%
Met (M)   8	  2.1%
Phe (F)  23	  6.1%
Pro (P)  24	  6.4%
Ser (S)  18	  4.8%
Thr (T)  17	  4.5%
Trp (W)   2	  0.5%
Tyr (Y)  15	  4.0%
Val (V)  16	  4.3%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 41
Total number of positively charged residues (Arg + Lys): 47

Atomic composition:

Carbon      C	      1959
Hydrogen    H	      3058
Nitrogen    N	       524
Oxygen      O	       546
Sulfur      S	        14

Formula: C1959H3058N524O546S14
Total number of atoms: 6101

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    33725
Abs 0.1% (=1 g/l)   0.782, assuming all pairs of Cys residues form cystines


Ext. coefficient    33350
Abs 0.1% (=1 g/l)   0.773, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 41.76
This classifies the protein as unstable.



Aliphatic index: 88.40

Grand average of hydropathicity (GRAVY): -0.341