ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSTMGKETES HSIPISEGQD AEHILYRLKR GSKLSVHPDA SLLGRKIVLY TNYPAEGQKF 

        70         80         90        100        110        120 
VRTEYRVLGW QLSNGKQITS VMHPEAHVVD TDIRSQVELN MSGTYHFYFR YLERPDTGCS 

       130        140        150        160        170        180 
GADGALYVQV EPTLHVGPPG AQKTIPLDSV RCQTVLAKLL GPLDTWEPKL RVAKEAGYNV 

       190        200        210        220        230        240 
IHFTPIQELG GSRSCYSLRD QLKVNSHFAP QKGGKISFED VEKVIKKCRQ EWGVASICDI 

       250        260        270        280        290        300 
VLNHTANESD WLLQHPDATY SCATCPYLRP AFLLDATFAQ CGADIAEGSL EHVGVPAVIE 

       310        320        330        340        350        360 
QECHLEALKY QLHTSYMSKV NIHELYQCDV MKYVNEFMSQ VRTREPPKNV ANECRFQEIQ 

       370        380        390        400        410        420 
LIQDPQYRRL ASTINFELAL EIFNAFHGDC FDEESRFRKC AETLRRHLDA LNDRVRCEVQ 

       430        440        450        460        470        480 
GYINYAIDNV LAGVRYERVQ GDGPRVKEIS EKHSVFMVYF THTGTQGKSL TEIEADMYTK 

       490        500        510        520        530        540 
AGEFFMAHNG WVMGYSDPLR DFAEEQPGRA NVYLKRELIS WGDSVKLRFG RRPEDSPYLW 

       550        560        570        580        590        600 
QHMTEYVQTT ARIFDGVRLD NCHSTPLHVA EYLLDAARKI NPELYVVAEL FTNSDYTDNV 

       610        620        630        640        650        660 
FVNRLGITSL IREALSAWDS HEQGRLVYRY GGVPVGGFQA NSSRHEATSV AHALFLDLTH 

       670        680        690        700        710        720 
DNPSPVEKRS VYDLLPSAAL VSMACCATGS NRGYDELVPH HIHVVDEERT YQEWGKGVDS 

       730        740        750        760        770        780 
KSGIMGAKRA LNLLHGQLAE EGFSQVYVDQ MDPNVVAVTR HSPITHQSVI LVAHTAFGYP 

       790        800        810        820        830        840 
SPNAGPTGIR PLRFEGVLDE IILEASLTMQ SDKPFDRPAP FKKDPNVING FTQFQLNLQE 

       850        860        870        880        890        900 
HIPLAKSTVF QTQAYSDGNN TELNFANLRP GTVVAIRVSM HPGPRTSFDK LQKISAALRI 

       910        920        930        940        950        960 
GSGEEYSQLQ AIVSKLDLVA LSGALFSCDD EERDLGKGGT AYDIPNFGKI VYCGLQGFIS 

       970        980        990       1000       1010       1020 
LLTEISPKND LGHPLCNNLR DGNWMMDYIS DRLTSYEDLK PLSAWFKATF EPLKNIPRYL 

      1030       1040       1050       1060       1070       1080 
IPCYFDAIVS GVYNVLINQV NELMPDFIKN GHSFPQSLAL STLQFLSVCK SANLPGFSPA 

      1090       1100       1110       1120       1130       1140 
LSPPKPPKQC VTLSAGLPHF STGYMRCWGR DTFIALRGSM FLTGRYNEAR FIIIGFGQTL 

      1150       1160       1170       1180       1190       1200 
RHGLIPNLLD SGSKPRFNCR DAIWWWMYCI KQYVEDAPKG AEILKDKVSR IFPYDDADAH 

      1210       1220       1230       1240       1250       1260 
APGAFDQLLF DVMQEALQVH FQGLQYRERN AGYEIDAHMV DQGFNNQIGI HPETGFVFGG 

      1270       1280       1290       1300       1310       1320 
NNFNCGTWMD KMGSSQKAGN KGRPSTPRDG SAVELVGLQY AVLRFMQSLA EKEVIPYTGV 

      1330       1340       1350       1360       1370       1380 
ERKGPSGEVT KWSYKEWADR IKNNFDKYFF VSESETCSVA NKKLIYKDSY GATQSWTDYQ 

      1390       1400       1410       1420       1430       1440 
LRCNFPITLT VAPDLCNPQN AWRALERAKK YLLGPLGMKT MDPEDWNYRA NYDNSNDSTD 

      1450       1460       1470       1480       1490       1500 
CTVAHGANYH QGPEWVWPIG FYLRARLIFA KKCGHLDETI AETWAILRAH LRELQTSHWR 

      1510       1520       1530       1540 
GLPELTNDNG SYCGDSCRTQ AWSVAAILEV LYDLHSLGAD VA 

References and documentation are available.

Number of amino acids: 1542

Molecular weight: 173578.52

Theoretical pI: 6.02

Amino acid composition: 
Ala (A) 112	  7.3%
Arg (R)  84	  5.4%
Asn (N)  70	  4.5%
Asp (D)  89	  5.8%
Cys (C)  34	  2.2%
Gln (Q)  67	  4.3%
Glu (E)  93	  6.0%
Gly (G) 111	  7.2%
His (H)  50	  3.2%
Ile (I)  73	  4.7%
Leu (L) 141	  9.1%
Lys (K)  71	  4.6%
Met (M)  30	  1.9%
Phe (F)  67	  4.3%
Pro (P)  80	  5.2%
Ser (S) 103	  6.7%
Thr (T)  76	  4.9%
Trp (W)  26	  1.7%
Tyr (Y)  66	  4.3%
Val (V)  99	  6.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 182
Total number of positively charged residues (Arg + Lys): 155

Atomic composition:

Carbon      C	      7751
Hydrogen    H	     11906
Nitrogen    N	      2128
Oxygen      O	      2289
Sulfur      S	        64

Formula: C7751H11906N2128O2289S64
Total number of atoms: 24138

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   243465
Abs 0.1% (=1 g/l)   1.403, assuming all pairs of Cys residues form cystines


Ext. coefficient   241340
Abs 0.1% (=1 g/l)   1.390, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 35.50
This classifies the protein as stable.



Aliphatic index: 80.01

Grand average of hydropathicity (GRAVY): -0.348