ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSVRNLTNNR HSNSENSVSG SENSFYSSNE QSRQSSSLEP ADGQNVRVSG NPFLGSEEFD 

        70         80         90        100        110        120 
EDYNSPSGDD ERRGANEYSS SSSINYNNDP NSDTSLLANE KNSPERNGQR MSDYKGYYAK 

       130        140        150        160        170        180 
TNLTSANNLN NHNNNNYKNI ISSSNDNSFA SHLQPPDRNL PSHPSSNNMS SFSNNSLIKS 

       190        200        210        220        230        240 
PPPFDRYPLV GTRHISAAQS QSQNLINEKK RANMTGSSSS AHDSSLSSTN LYMGEQDFSP 

       250        260        270        280        290        300 
FGGYPASFFP LTLDEKEDDD YIHNPNVEEE AKLDRRRFVD DFKHMDRRSF LGLLGILFLF 

       310        320        330        340        350        360 
MAGIFIFIVL PAITFSGVVY HHEHVHAANS AGSSSSNTTS KSLTEYQYPQ LAAIRTTLVD 

       370        380        390        400        410        420 
PDTPDSAKTR VAKDGSKWQL VFSDEFNAEG RTFYDGDDQF WTAPDIHYDA TKDLEWYSPD 

       430        440        450        460        470        480 
AVTTTNGTLT LRMDAFRNHD LYYRSGMVQS WNKLCFTEGA LEVSANLPNY GRVTGLWPGM 

       490        500        510        520        530        540 
WTMGNLGRPG YLASTQGVWP YSYEACDAGI TPNQSSPDGI SYLPGQKLSV CTCDNEDHPN 

       550        560        570        580        590        600 
QGVGRGAPEI DILEGEADTI LGVGVASQSL QIAPFDIWYM PDYDFIEVYN FTTTTMNTYA 

       610        620        630        640        650        660 
GGPFQQAVSA ISTLNVTWYE FGEEAGYFQK YAIEYLNDDD NGYIRWFVGE NPTFTLYATS 

       670        680        690        700        710        720 
LHPSGNIDWR RISKEPMSAI LNLGISNNWA YIDWQYIFFP VTMSIDYVRL YQPKGSTSIT 

       730        740        750        760        770 
CDPEDYPTYD YIQSHLNAYY NANLTDWEQA GYTFPKNILT GGCSSSKFSL S 

References and documentation are available.

Number of amino acids: 771

Molecular weight: 86241.16

Theoretical pI: 4.68

Amino acid composition: 
Ala (A)  46	  6.0%
Arg (R)  30	  3.9%
Asn (N)  67	  8.7%
Asp (D)  54	  7.0%
Cys (C)   6	  0.8%
Gln (Q)  27	  3.5%
Glu (E)  39	  5.1%
Gly (G)  52	  6.7%
His (H)  17	  2.2%
Ile (I)  35	  4.5%
Leu (L)  53	  6.9%
Lys (K)  22	  2.9%
Met (M)  15	  1.9%
Phe (F)  36	  4.7%
Pro (P)  43	  5.6%
Ser (S)  93	 12.1%
Thr (T)  48	  6.2%
Trp (W)  14	  1.8%
Tyr (Y)  45	  5.8%
Val (V)  29	  3.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 93
Total number of positively charged residues (Arg + Lys): 52

Atomic composition:

Carbon      C	      3805
Hydrogen    H	      5657
Nitrogen    N	      1025
Oxygen      O	      1238
Sulfur      S	        21

Formula: C3805H5657N1025O1238S21
Total number of atoms: 11746

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   144425
Abs 0.1% (=1 g/l)   1.675, assuming all pairs of Cys residues form cystines


Ext. coefficient   144050
Abs 0.1% (=1 g/l)   1.670, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 54.75
This classifies the protein as unstable.



Aliphatic index: 61.39

Grand average of hydropathicity (GRAVY): -0.636