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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MSVVTTTSMQ SDSKKRVQLM GDTTSPFSLD TPNPKLMFTP LDLPTTAELM QRCLAVNPFE

70 80 90 100 110 120
AKFREANQKI SSGSMQPNTS GANQSLEALE ANGGSQFSGS NAGTMSDLLL KIPQASLQHS

130 140 150 160 170 180
PGIFSNMLLN AGDSEGTTRE NLKTADISKL LSVAGDFSAQ APRTADVLNA VLDMHSDRLH

190 200 210 220 230 240
TINYLNNKPD FSALLRSPSS SAPNSASVLT NAMAIPSTSG APFPGTTLLV PPKTVSSYHS

250 260 270 280 290 300
PLGASSQPPS TQKSPADGSW DHINGEKQIK KEIPYFNDDA MMLMERSNMS SSGSDQDQSA

310 320 330 340 350 360
DMSNAGSTAS TSTGNPVGRP QNGTPGRGRG RGRSTTADMQ PDERRNTILE RNKAAAVRYR

370 380 390 400 410 420
KRKKEEHDDM MGRVQAMEAE KNQLLAIQTQ NQVLRRELER VTALLTERES RCVCLKGVPM

430 440 450 460
SDEQHADHHH RNTNGMYSGS DMLNGLGQIN GMQLKLPKLQ


References and documentation are available.

Number of amino acids: 460 Molecular weight: 49722.67 Theoretical pI: 7.77
Amino acid composition: 
Ala (A) 37 8.0% Arg (R) 26 5.7% Asn (N) 30 6.5% Asp (D) 26 5.7% Cys (C) 3 0.7% Gln (Q) 26 5.7% Glu (E) 21 4.6% Gly (G) 32 7.0% His (H) 10 2.2% Ile (I) 12 2.6% Leu (L) 42 9.1% Lys (K) 22 4.8% Met (M) 23 5.0% Phe (F) 10 2.2% Pro (P) 29 6.3% Ser (S) 55 12.0% Thr (T) 33 7.2% Trp (W) 1 0.2% Tyr (Y) 5 1.1% Val (V) 17 3.7% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 47 Total number of positively charged residues (Arg + Lys): 48 Atomic composition: Carbon C 2103 Hydrogen H 3417 Nitrogen N 637 Oxygen O 704 Sulfur S 26 Formula: C2103H3417N637O704S26 Total number of atoms: 6887 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 13075 Abs 0.1% (=1 g/l) 0.263, assuming all pairs of Cys residues form cystines Ext. coefficient 12950 Abs 0.1% (=1 g/l) 0.260, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 41.62 This classifies the protein as unstable. Aliphatic index: 64.54 Grand average of hydropathicity (GRAVY): -0.648