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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MTANNDDDIK SPIPITNKTL SQLKRFERSP GRPSSSQGEI KRKKSRLYAA DGRPHSPLRA 

        70         80         90        100        110        120 
RSATPTLQDQ KLFNGMDSTS LLNERLQHYT LDYVSDRAQH MKNIYDPSSR WFSRSVRPEF 

       130        140        150        160        170        180 
PIEEFLPYKT ESHEDQAKYL CHVLVNLYIA ISSLDIQGLI SISSKDLADL KKEVDDLALK 

       190        200        210        220        230        240 
TDLFRLSNNT AENDLLGNDI ADYDDAEGLE DELDEYFDLA GPDFNATGKI TAKSATIVNV 

       250        260        270        280        290        300 
NHWTNELKNC LHFDFPVALR KSLATVYYYL SLVQGQKVYR QMHVDMFERL VSLDDDRTNF 

       310        320        330        340        350        360 
TELLQKQGLL LDHQIMLNFL CEFLPYPDPD YARYELSSKE DLQLFRLLLK HAHNAKPFFD 

       370        380        390        400        410        420 
KSKESLLVDT MNFLLSSLAP STMMAVMPIV TSVVPYHYHI HSKIIDYFPF CYSIWSSVSA 

       430        440        450        460        470        480 
NVAIDTHMYD FVGSISKDVH NKILSSEHEK DVVGVEFGEF GIFTDDQMTF MFNRLQGHLR 

       490        500        510        520        530        540 
TDGQIHSYSR TVKPFVYAIN GSKKDRFFEK LVSLAKAIET FIHPSNNGFW TKPNAKFVHA 

       550        560        570        580        590        600 
FIKSYHGRVK YEEDICARGV TNGICLTSFC HEEIVEIFLN IISLGSQNKN PDIANYYISC 

       610        620        630        640        650        660 
FAYLLELDPS NAYLIYDKIL IDLYDTLADQ FINSRHRIIS SLKQFTRVIR FIVMDKLYRV 

       670        680        690        700        710        720 
HITNVLSMLV SKLDMNDTNL TSNLINGIVS IAAFIPIQDL TGEDDYISFE SDTLPLVQQH 

       730        740        750        760        770        780 
FYHIKCGESS KTFRVDDELL NNAFKASTTV FQSMLKVYVE KIFQLVDVDL EDSLVTKINQ 

       790        800        810        820        830        840 
TTMILQESMD DKIFNYFASL LQRNFWSNDS FKEKDPNYEL VTIPLAALVR RNNGLSKELV 

       850        860        870        880        890        900 
RTLLFHIKEQ IKRGAGSVRS TSEIQQRDVK LVLYLTALND VLRQCHESLL EYSDELITFM 

       910        920        930        940        950        960 
KYLYDNVTNP PLDVITSIVI HSALATLCTT EITDCRLFPE DSKIPEKDRW GGLQFDPRRF 

       970        980        990       1000       1010       1020 
DKQHLSFQWH VPSSDEITLS ISILESLSEY CINNVEELMK APRHDSEYGD MIQKYVLVMT 

      1030       1040       1050       1060       1070       1080 
HTLSGSSLLF DPDFNKYRTQ SNLSYREKLI LLKNIRENNC DPQELDIDIE QIRSGKDDED 

      1090       1100       1110       1120       1130       1140 
YIESKDIEAG LNAGVSDVVQ LRDEFPDELI VDEEVVSEMP SGVNTPIAGT HGTDNSAMSS 

      1150       1160       1170       1180       1190       1200 
DLAFRDLDIY TCNYYFGNTT EEKLQNPQYL QVHRVRARIG HFFHKLYVFL STNFENNTNM 

      1210       1220       1230       1240       1250       1260 
FQILLHGLKV WFTDLGQETV FNEDPNAFID VDFLENVQSL SHVNEPFTRT NFAIRANSLH 

      1270       1280       1290       1300       1310       1320 
QSRVLLHSTN RKASKLENLL LVDIIQLATS LYPDIYKPAQ GTLVHCMKQL VGSYGVVINK 

      1330       1340       1350       1360       1370       1380 
IIPSLEKAIK DHDYMKIQVI LNVLLIKKIH RKLMTDYKDI GRLIFLLIEC CRVNELEIGM 

      1390       1400       1410       1420       1430       1440 
YADKILTDIV IGIKIPSSVC VISDQAFLPL APPDGTINLQ VEAVKLAKKK KREYYLSLLV 

      1450       1460       1470       1480       1490       1500 
DLQDKLLDKL DNEKDMGWKI RMFILRFVTQ IQSNLESKPD KRAVFSIISQ ISTKHPEIIH 

      1510       1520       1530       1540       1550       1560 
LVVKSLLSTC NKIISLSDYE YDITRAYKNE FNPSFVEILD TSTTSFPKTF TEEMNNFDNP 

      1570       1580       1590       1600       1610       1620 
KYFIDLRAYV GWLCWGRLMY VMSPKALKLN LRENELEVLK TAGHLLTREF LRDVTMNLVQ 

      1630       1640       1650       1660       1670       1680 
DNETRGVFSS GNVSFFSLVI LLISSGFCEL NMSDLFELCE SYYNKDDKAS MIMSVEIVAG 

      1690       1700       1710       1720       1730       1740 
LVCGSKFMSV SDLDKRDTFI ENFLAKCLDY ELNHDAFEIW STLAWWLPAV VDLRRSKTFF 

      1750       1760       1770       1780       1790       1800 
CHFINADGMF DRESDAATHQ TSKIYMLRSI LMSMEFRAPD VGKLFDELVF DHPYDQVRQA 

      1810       1820       1830       1840       1850       1860 
VAKLLTTLVQ NQSNPSISDP TTLLEAERND PDGLGLPLKS VPEKVDAYIK KQFEIIKNLE 

      1870       1880       1890       1900       1910       1920 
DSVVGLNPQQ FIKTDYFYRT STIFYWIKEM ARGPNKVLLV PYLVDYVLPF LIGLVKHKDV 

      1930       1940       1950       1960       1970       1980 
CALASLDPVR LYAGLGYMPI RKNHVAAIVD YVCSSNVALS SNQTKLQLAF IQHFLSAELL 

      1990       2000       2010       2020       2030       2040 
QLTEEEKNKI LEFVVSNLYN EQFVEVRVRA ASILSDIVHN WKEEQPLLSL IERFAKGLDV 

      2050       2060       2070       2080       2090       2100 
NKYTSKERQK LSKTDIKIHG NVLGLGAIIS AFPYVFPLPP WIPKQLSNLS SWARTSGMTG 

      2110       2120       2130       2140 
QAAKNTISEF KKVRADTWKF DRASFNTEEL EDLEGVLWRS YYA


References and documentation are available. 

Number of amino acids: 2143

Molecular weight: 245995.54

Theoretical pI: 5.58


Amino acid composition: 
Ala (A) 105	  4.9%
Arg (R)  92	  4.3%
Asn (N) 116	  5.4%
Asp (D) 157	  7.3%
Cys (C)  28	  1.3%
Gln (Q)  76	  3.5%
Glu (E) 128	  6.0%
Gly (G)  75	  3.5%
His (H)  57	  2.7%
Ile (I) 151	  7.0%
Leu (L) 250	 11.7%
Lys (K) 139	  6.5%
Met (M)  47	  2.2%
Phe (F) 115	  5.4%
Pro (P)  78	  3.6%
Ser (S) 175	  8.2%
Thr (T) 109	  5.1%
Trp (W)  20	  0.9%
Tyr (Y)  85	  4.0%
Val (V) 140	  6.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%



Total number of negatively charged residues (Asp + Glu): 285
Total number of positively charged residues (Arg + Lys): 231

Atomic composition:

Carbon      C	     11101
Hydrogen    H	     17326
Nitrogen    N	      2884
Oxygen      O	      3275
Sulfur      S	        75

Formula: C11101H17326N2884O3275S75
Total number of atoms: 34661

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   238400
Abs 0.1% (=1 g/l)   0.969, assuming all pairs of Cys residues form cystines


Ext. coefficient   236650
Abs 0.1% (=1 g/l)   0.962, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 38.85
This classifies the protein as stable.



Aliphatic index: 96.82

Grand average of hydropathicity (GRAVY): -0.196