ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MTDVLRSLVR KISFNNSDNL QLKHKTSIQS NTALEKKKRK PDTIKKVSDV QVHHTVPNFN 

        70         80         90        100        110        120 
NSSEYINDIE NLIISKLIDG GKEGIAVDHI EHANISDSKT DGKVANKHEN ISSKLSKEKV 

       130        140        150        160        170        180 
EKMINFDYRY IKTKERTIHK RVYKHDRKTD VDRKNHGGTI DISYPTTEVV GHGSFGVVVT 

       190        200        210        220        230        240 
TVIIETNQKV AIKKVLQDRR YKNRELETMK MLCHPNTVGL QYYFYEKDEE DEVYLNLVLD 

       250        260        270        280        290        300 
YMPQSLYQRL RHFVNLKMQM PRVEIKFYAY QLFKALNYLH NVPRICHRDI KPQNLLVDPT 

       310        320        330        340        350        360 
TFSFKICDFG SAKCLKPDQP NVSYICSRYY RAPELMFGAT NYSNQVDVWS SACVIAELLL 

       370        380        390        400        410        420 
GKPLFSGESG IDQLVEIIKI MGIPTKDEIS GMNPNYEDHV FPNIKPITLA EIFKAEDPDT 

       430        440        450        460        470        480 
LDLLTKTLKY HPCERLVPLQ CLLSSYFDET KRCDTDTYVK AQNLRIFDFD VETELGHVPL 

       490        500 
VERPAIEERL KHFVSAPSSS L 

References and documentation are available.

Number of amino acids: 501

Molecular weight: 57819.30

Theoretical pI: 8.17

Amino acid composition: 
Ala (A)  17	  3.4%
Arg (R)  23	  4.6%
Asn (N)  29	  5.8%
Asp (D)  34	  6.8%
Cys (C)   9	  1.8%
Gln (Q)  16	  3.2%
Glu (E)  33	  6.6%
Gly (G)  18	  3.6%
His (H)  18	  3.6%
Ile (I)  37	  7.4%
Leu (L)  44	  8.8%
Lys (K)  47	  9.4%
Met (M)  10	  2.0%
Phe (F)  19	  3.8%
Pro (P)  23	  4.6%
Ser (S)  33	  6.6%
Thr (T)  29	  5.8%
Trp (W)   1	  0.2%
Tyr (Y)  23	  4.6%
Val (V)  38	  7.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 67
Total number of positively charged residues (Arg + Lys): 70

Atomic composition:

Carbon      C	      2584
Hydrogen    H	      4095
Nitrogen    N	       699
Oxygen      O	       766
Sulfur      S	        19

Formula: C2584H4095N699O766S19
Total number of atoms: 8163

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    40270
Abs 0.1% (=1 g/l)   0.696, assuming all pairs of Cys residues form cystines


Ext. coefficient    39770
Abs 0.1% (=1 g/l)   0.688, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 38.72
This classifies the protein as stable.



Aliphatic index: 88.44

Grand average of hydropathicity (GRAVY): -0.478