ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MTGHTGDVSQ VHDIEILALN PTVNKHATFK PTIVSKKDKE NWARLDHCKK GCELKNDFED 

        70         80         90        100        110        120 
VKPTTLTERG ALFESARCLK CADAPCQKGC PTQLDIKSFI SSISTKNYYG AAKTIFSDNP 

       130        140        150        160        170        180 
LGLTCGMVCP VSSLCQYGCN LAATEEGPIN IGGLQQFATE VFKKMNIPQI RDPSLTPLSQ 

       190        200        210        220        230        240 
LPESYKAKIA LIGCGPTSIS CATFLGRLGY TDVTIFEKEQ YLGGLSSSEI PNYRLNYEVV 

       250        260        270        280        290        300 
EFEIKLMKDL GVKVEYGKRL GENGFTVESL QKQGYEAIYL GIGMPEPKID PVFNELTSDQ 

       310        320        330        340        350        360 
GFFSSKEFLP KVSKASKAGM CGCKSQLPQL NGRVIVLGAG DTAFDCATSA FRCGASRVTV 

       370        380        390        400        410        420 
CFRRGFSDMR AVPEEVDIAK DERCEFLPYV LPKQVIKRDG KVVAMEFYKT EKGDDGNYSV 

       430        440        450        460        470        480 
DEDQFFRVKC DYIISAFGSQ IGSVAESCSP LQFNKWGTAD IDPMTMTSKH AEWLFCGGDL 

       490        500        510        520        530        540 
VGNGTTVEAV NDGKTASWNI HKYLQSLHGI PIPDGPPQLP NFFTPIDLVD ISVEMCGMKF 

       550        560        570        580        590        600 
PNPFGLASAT PATSAAMIRR SFEQGWGFAV TKTFSLDKDL VTNVSPRIVR GTTSGHHFGP 

       610        620        630        640        650        660 
GQGAFLNIEL ISEKTCHYWC KAIGELKRDF PDRIVIASIM CGFNKEDWTQ LAKMAEASGA 

       670        680        690        700        710        720 
DGIELNLSCP HGMGEKGMGL ACGQDTELVF HICQWVRAAT RLPFFAKLTP NVTEIKEIAK 

       730        740        750        760        770        780 
AAHDGGADGV TAINTVSGLM GLKGDSNAWP AIGDEKRTTY GGVSGNATRP IALRAVSSIR 

       790        800        810        820        830        840 
KSLPDYPIMA TGGADSADAT IQFLHCGASV VQICSSVQNQ DFTVVQDYIT GLKTYLYMQS 

       850        860        870        880        890        900 
REDLLQWDGQ SPPNEIINKN PKLKGLPKFG KYLLERNRID TEEKQNIDLQ KVKNPLVPSP 

       910        920        930        940        950        960 
NPTHPVPSLK DQINRAIPRI GRHDDLKRDQ QVVALIDEDK CINCGKCYMT CNDSGYQAIK 

       970        980        990       1000 
FDGKTHIPLV TDLCTGCDLC LSVCPVPDCI TMVPRETIYV PDRGLTVQN 

References and documentation are available.

Number of amino acids: 1009

Molecular weight: 110444.38

Theoretical pI: 6.09

Amino acid composition: 
Ala (A)  67	  6.6%
Arg (R)  37	  3.7%
Asn (N)  41	  4.1%
Asp (D)  64	  6.3%
Cys (C)  39	  3.9%
Gln (Q)  40	  4.0%
Glu (E)  53	  5.3%
Gly (G)  87	  8.6%
His (H)  17	  1.7%
Ile (I)  65	  6.4%
Leu (L)  77	  7.6%
Lys (K)  71	  7.0%
Met (M)  22	  2.2%
Phe (F)  44	  4.4%
Pro (P)  59	  5.8%
Ser (S)  64	  6.3%
Thr (T)  64	  6.3%
Trp (W)  10	  1.0%
Tyr (Y)  26	  2.6%
Val (V)  62	  6.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 117
Total number of positively charged residues (Arg + Lys): 108

Atomic composition:

Carbon      C	      4882
Hydrogen    H	      7694
Nitrogen    N	      1316
Oxygen      O	      1479
Sulfur      S	        61

Formula: C4882H7694N1316O1479S61
Total number of atoms: 15432

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    96115
Abs 0.1% (=1 g/l)   0.870, assuming all pairs of Cys residues form cystines


Ext. coefficient    93740
Abs 0.1% (=1 g/l)   0.849, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.32
This classifies the protein as stable.



Aliphatic index: 79.35

Grand average of hydropathicity (GRAVY): -0.228