ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MTGIKAQVHP PPDSTLFHEE EKKKVGGNLP QKVINQQERG SDHAPSGHHQ YHQLINHDAN 

        70         80         90        100        110        120 
DTKTSNSVSD VSKGQKTADS NPEGKKQSSK DIFVASSAQK TNQLPGPNPQ GSIGAVPLEG 

       130        140        150        160        170        180 
LRPKEFRSAP SRKPNKFDTS ITKPGVLDDL GKLDEKDIKE KFHLDSDDKL FPWQNVGEFH 

       190        200        210        220        230        240 
ASGKGSPNTK MSRVIKAYIL ENFYNDWYCN IATVLGTCFF SWLFAYIGFS WWSMIFIFLG 

       250        260        270        280        290        300 
TATVYNAEYT RFNRNIRDDL KRVTVEETLS DRVESTTWLN SFLSKFWVIY MPVLSQQVKD 

       310        320        330        340        350        360 
NVNPQLAGVA PGYGIDALAI DEFTLGSKAP TIKGIKSYTK TGKNTVEMDW SFAFTPSDVS 

       370        380        390        400        410        420 
DMTATEAREK INPKISLGVT LGKSFVSKTM PILVEDINVA GKMRIKVEFG KAFPNIKIVS 

       430        440        450        460        470        480 
LQLLEPPLID FALKPIGGDT LGLDVMSFLP GLKSFVKNII NSNIGPMLFP PNHLDINVED 

       490        500        510        520        530        540 
IMAAQSKEAI GVLAVTIASA DSLKGSDFIT NTVDPYIVMT TEDAVPGTDE EVRTSIKSNV 

       550        560        570        580        590        600 
KNPRWNETKY LLLNTLEQKL NLKCFDFNDV RKDTVIGDLQ LDLADLLQNP VLDNQTAELR 

       610        620        630        640        650        660 
SGTKSKGILH YSLHWFPVKE DKSEEKAVER AEAKAKGKKE DENEDTTEKE EDENEESSQT 

       670        680        690        700        710        720 
DVGIAKITLQ KVKYLDTTSS MTGSLSPCAE LFIDGQKVKS YRTLRRINEP SWNETIEVLV 

       730        740        750        760        770        780 
PSKSNSKFVL KIFDDRMNGK ALICEYSSSL DDIMTTLDTA QEFVKGSPQG DIYLDVSWKS 

       790        800        810        820        830        840 
IEMTGAFAAA NSVSEPIGCI KLDVKDAIIK GDLSGVGDVD PYYTVSLNRR VLYKSIYHSD 

       850        860        870        880        890        900 
TDHPIFDNST YVPIFSPNQI LTLEFHDYQK IGKDRFIGSV QIPTSNVFKK DPKSGKYVGN 

       910        920        930        940        950        960 
NGKEEISKLK LKDHEHKVTE SIVNVSTTFI PINLVYSPEE LVNVEKLEKE LKEKKKKFEA 

       970        980        990       1000       1010       1020 
TQEENEQEME KNPKEWEVAE IEDPFDSDEK KINRKAKLSL NELIKQKSGI LSMQILEGTL 

      1030       1040       1050       1060       1070       1080 
SPSSAYLEIL ADDISYPVFI CMKPSQGKLN SEMANIFIRD LNYSKLHFRV SKKHIAKDSD 

      1090       1100       1110       1120       1130       1140 
DVISETSYST LKLLKQAYEE PMWLNFNGSK MKVRFLYTPT SVKLPSSESV EDTGYLNIKL 

      1150       1160       1170       1180       1190       1200 
ISGHGLKSAD RNGYSDPFVH IFVNDKKVFK SNIKKKTLDP VWNEDAKIPI LSRSKNQVIF 

      1210       1220       1230       1240       1250       1260 
NVLDWDRAGD NDDLGQASLD VSSLEVGKTY NWNLNLNTQG SIKLQGSFNP EYIKPSFDIV 

      1270       1280       1290       1300       1310       1320 
KGGITDKPMK IASGAAHATV GIAGTGIGAA TGVATGGLKK GGHLLKSLGG NPMKRSKSSN 

      1330       1340       1350       1360       1370       1380 
GNESNGAKKS SEKKSFDRRS PSNLNSTSVT PRASLDYDPS VPNTSYAPVQ SASPVVKPTD 

      1390       1400       1410       1420       1430       1440 
NTSSSSNKKD TPSSNSRGHS RASSFARTLA PHGTYNGFIT VVAAENVAKH VQIKISLTQG 

      1450       1460       1470       1480       1490       1500 
GRLKHIYKTK SQKANNDGVA VFDEECSFKA SPEANLVLGA ISHQRLSRDK DLGIAQINLG 

      1510       1520       1530       1540 
DPQIQQDGQI SVKLGDGHLI VKINYGKDKN GQVPPVPEVP QEYTQ 

References and documentation are available.

Number of amino acids: 1545

Molecular weight: 171075.58

Theoretical pI: 6.69

Amino acid composition: 
Ala (A)  83	  5.4%
Arg (R)  41	  2.7%
Asn (N)  94	  6.1%
Asp (D) 105	  6.8%
Cys (C)   8	  0.5%
Gln (Q)  52	  3.4%
Glu (E)  94	  6.1%
Gly (G) 100	  6.5%
His (H)  29	  1.9%
Ile (I) 102	  6.6%
Leu (L) 122	  7.9%
Lys (K) 153	  9.9%
Met (M)  24	  1.6%
Phe (F)  60	  3.9%
Pro (P)  79	  5.1%
Ser (S) 150	  9.7%
Thr (T)  89	  5.8%
Trp (W)  17	  1.1%
Tyr (Y)  41	  2.7%
Val (V) 102	  6.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 199
Total number of positively charged residues (Arg + Lys): 194

Atomic composition:

Carbon      C	      7608
Hydrogen    H	     12054
Nitrogen    N	      2042
Oxygen      O	      2370
Sulfur      S	        32

Formula: C7608H12054N2042O2370S32
Total number of atoms: 24106

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   155090
Abs 0.1% (=1 g/l)   0.907, assuming all pairs of Cys residues form cystines


Ext. coefficient   154590
Abs 0.1% (=1 g/l)   0.904, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 33.70
This classifies the protein as stable.



Aliphatic index: 81.06

Grand average of hydropathicity (GRAVY): -0.495