ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MTLHLYHHSR FLWRNLCFPR SVGNLCNRNC SLISPSLARS AKYYCSSVAV SEFSNEAASG 

        70         80         90        100        110        120 
STLTSISEDV TPQSIKYPFK SEERVASTAA SSNGRVMLID GTSIIYRAYY KLLARLNHGH 

       130        140        150        160        170        180 
LAHADGNADW VLTIFSSLSL LIDVLKFLPS HVAVVFDHDG VPYGTTSNSS TGYRSAKGMN 

       190        200        210        220        230        240 
FRHTLYPAYK SNRPPTPDTI VQGLQYLKAS IKAMSIKVIE VPGVEADDVI GTLAMRSISA 

       250        260        270        280        290        300 
GFKVRVVSPD KDFFQILSPS LRLLRLTPRG SEMASFGMED FAKKFGNLEP AQFVDIIALA 

       310        320        330        340        350        360 
GDKSDNIPGV DGIGNVHAVE LISRFGTLEN LLQSVDEIKE GKIKESLIAS ADQAILSKKL 

       370        380        390        400        410        420 
ALLRSDLPDY IVPFDTKDLT FKKPEDNGEK LSSLLIAIAD YAEGFSADPV IRRAFRLWEK 


LEAVP 

References and documentation are available.

Number of amino acids: 425

Molecular weight: 46689.45

Theoretical pI: 7.69

Amino acid composition: 
Ala (A)  37	  8.7%
Arg (R)  22	  5.2%
Asn (N)  16	  3.8%
Asp (D)  26	  6.1%
Cys (C)   4	  0.9%
Gln (Q)   7	  1.6%
Glu (E)  20	  4.7%
Gly (G)  25	  5.9%
His (H)  10	  2.4%
Ile (I)  28	  6.6%
Leu (L)  46	 10.8%
Lys (K)  25	  5.9%
Met (M)   7	  1.6%
Phe (F)  20	  4.7%
Pro (P)  21	  4.9%
Ser (S)  48	 11.3%
Thr (T)  18	  4.2%
Trp (W)   3	  0.7%
Tyr (Y)  14	  3.3%
Val (V)  28	  6.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 46
Total number of positively charged residues (Arg + Lys): 47

Atomic composition:

Carbon      C	      2097
Hydrogen    H	      3316
Nitrogen    N	       562
Oxygen      O	       621
Sulfur      S	        11

Formula: C2097H3316N562O621S11
Total number of atoms: 6607

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    37610
Abs 0.1% (=1 g/l)   0.806, assuming all pairs of Cys residues form cystines


Ext. coefficient    37360
Abs 0.1% (=1 g/l)   0.800, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 34.89
This classifies the protein as stable.



Aliphatic index: 95.72

Grand average of hydropathicity (GRAVY): -0.050