ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MTNEKVWIEK LDNPTLSVLP HDFLRPQQEP YTKQATYSLQ LPQLDVPHDS FSNKYAVALS 

        70         80         90        100        110        120 
VWAALIYRVT GDDDIVLYIA NNKILRFNIQ PTWSFNELYS TINNELNKLN SIEANFSFDE 

       130        140        150        160        170        180 
LAEKIQSCQD LERTPQLFRL AFLENQDFKL DEFKHHLVDF ALNLDTSNNA HVLNLIYNSL 

       190        200        210        220        230        240 
LYSNERVTIV ADQFTQYLTA ALSDPSNCIT KISLITASSK DSLPDPTKNL GWCDFVGCIH 

       250        260        270        280        290        300 
DIFQDNAEAF PERTCVVETP TLNSDKSRSF TYRDINRTSN IVAHYLIKTG IKRGDVVMIY 

       310        320        330        340        350        360 
SSRGVDLMVC VMGVLKAGAT FSVIDPAYPP ARQTIYLGVA KPRGLIVIRA AGQLDQLVED 

       370        380        390        400        410        420 
YINDELEIVS RINSIAIQEN GTIEGGKLDN GEDVLAPYDH YKDTRTGVVV GPDSNPTLSF 

       430        440        450        460        470        480 
TSGSEGIPKG VLGRHFSLAY YFNWMSKRFN LTENDKFTML SGIAHDPIQR DMFTPLFLGA 

       490        500        510        520        530        540 
QLYVPTQDDI GTPGRLAEWM SKYGCTVTHL TPAMGQLLTA QATTPFPKLH HAFFVGDILT 

       550        560        570        580        590        600 
KRDCLRLQTL AENCRIVNMY GTTETQRAVS YFEVKSKNDD PNFLKKLKDV MPAGKGMLNV 

       610        620        630        640        650        660 
QLLVVNRNDR TQICGIGEIG EIYVRAGGLA EGYRGLPELN KEKFVNNWFV EKDHWNYLDK 

       670        680        690        700        710        720 
DNGEPWRQFW LGPRDRLYRT GDLGRYLPNG DCECCGRADD QVKIRGFRIE LGEIDTHISQ 

       730        740        750        760        770        780 
HPLVRENITL VRKNADNEPT LITFMVPRFD KPDDLSKFQS DVPKEVETDP IVKGLIGYHL 

       790        800        810        820        830        840 
LSKDIRTFLK KRLASYAMPS LIVVMDKLPL NPNGKVDKPK LQFPTPKQLN LVAENTVSET 

       850        860        870        880        890        900 
DDSQFTNVER EVRDLWLSIL PTKPASVSPD DSFFDLGGHS ILATKMIFTL KKKLQVDLPL 

       910        920        930        940        950        960 
GTIFKYPTIK AFAAEIDRIK SSGGSSQGEV VENVTANYAE DAKKLVETLP SSYPSREYFV 

       970        980        990       1000       1010       1020 
EPNSAEGKTT INVFVTGVTG FLGSYILADL LGRSPKNYSF KVFAHVRAKD EEAAFARLQK 

      1030       1040       1050       1060       1070       1080 
AGITYGTWNE KFASNIKVVL GDLSKSQFGL SDEKWMDLAN TVDIIIHNGA LVHWVYPYAK 

      1090       1100       1110       1120       1130       1140 
LRDPNVISTI NVMSLAAVGK PKFFDFVSST STLDTEYYFN LSDKLVSEGK PGILESDDLM 

      1150       1160       1170       1180       1190       1200 
NSASGLTGGY GQSKWAAEYI IRRAGERGLR GCIVRPGYVT GASANGSSNT DDFLLRFLKG 

      1210       1220       1230       1240       1250       1260 
SVQLGKIPDI ENSVNMVPVD HVARVVVATS LNPPKENELA VAQVTGHPRI LFKDYLYTLH 

      1270       1280       1290       1300       1310       1320 
DYGYDVEIES YSKWKKSLEA SVIDRNEENA LYPLLHMVLD NLPESTKAPE LDDRNAVASL 

      1330       1340       1350       1360       1370       1380 
KKDTAWTGVD WSNGIGVTPE EVGIYIAFLN KVGFLPPPTH NDKLPLPSIE LTQAQISLVA 

      1390 
SGAGARGSSA AA 

References and documentation are available.

Number of amino acids: 1392

Molecular weight: 155345.60

Theoretical pI: 5.63

Amino acid composition: 
Ala (A)  91	  6.5%
Arg (R)  61	  4.4%
Asn (N)  80	  5.7%
Asp (D)  97	  7.0%
Cys (C)  14	  1.0%
Gln (Q)  42	  3.0%
Glu (E)  75	  5.4%
Gly (G)  90	  6.5%
His (H)  26	  1.9%
Ile (I)  81	  5.8%
Leu (L) 142	 10.2%
Lys (K)  86	  6.2%
Met (M)  21	  1.5%
Phe (F)  61	  4.4%
Pro (P)  74	  5.3%
Ser (S)  95	  6.8%
Thr (T)  86	  6.2%
Trp (W)  18	  1.3%
Tyr (Y)  51	  3.7%
Val (V) 101	  7.3%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 172
Total number of positively charged residues (Arg + Lys): 147

Atomic composition:

Carbon      C	      6979
Hydrogen    H	     10903
Nitrogen    N	      1853
Oxygen      O	      2091
Sulfur      S	        35

Formula: C6979H10903N1853O2091S35
Total number of atoms: 21861

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   175865
Abs 0.1% (=1 g/l)   1.132, assuming all pairs of Cys residues form cystines


Ext. coefficient   174990
Abs 0.1% (=1 g/l)   1.126, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 28.57
This classifies the protein as stable.



Aliphatic index: 90.06

Grand average of hydropathicity (GRAVY): -0.257