ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVEIMKKSSK QETVKVIVRC RPLSSQEIAN NYSKIVHMRP QRGQIELKNP KEQDEPSKDF 

        70         80         90        100        110        120 
TFDAIYDENS TQSDLYEETF RDLVDSVLNG YNATIFAYGQ TGTGKTHTME GKSSDPEQRG 

       130        140        150        160        170        180 
VIYKCIDHIF EHMAASHNQE YLVRASYLEI YQEELRDLLE AESNKKLEIK ERPDGGVYVK 

       190        200        210        220        230        240 
DLTSKLTRTV GEIHEVMIRG NGHRSVGRTN MNEHSSRSHA IFIITVECSR IGEDGESHIT 

       250        260        270        280        290        300 
VGRLNLVDLA GSERQSKTGA TGERFKEATK INLSLSALGN VISALVDAKS AHIPYRDSKL 

       310        320        330        340        350        360 
TRLLQDSLGG NSKTVMVACI GPASYNFEET LGTLRYANRA KNIKNQPKIN EDPKDALLRE 

       370        380        390        400        410        420 
FQEEIEMLRE QLKQRKTRSR DGATQSFYDA ERAKLEDDIE AIQKDDSLIK HEKDRLIREI 

       430        440        450        460        470        480 
QEKHDLLEKE RIEQARVAER IANIQSRLIV GSEEDGRLES RTKEQHAQLE KKRRELAEQK 

       490        500        510        520        530        540 
RREREMVEAL ERQEEDTVDL KQTFSDLRTE VEAKTKKLKK MLIKLRQARN EIRDVSGAYS 

       550        560        570        580        590        600 
DERQDLDQTI AEVSKELKLK LLIVENFIPR DVSERIKERA EWNEDSFEWN VNAFQSTSSN 

       610        620        630        640        650        660 
SSTPLNNTIE VNEDGVFTRS SGADSGVSVS GGNGTPATSQ FLDKRLVATP GCRRPMSMCE 

       670        680        690        700        710        720 
RMLVETAREQ FGAQRRPPIS GSGSFVEATI PEETIRFCGE NVVVFSALER FVPEVTDSDP 

       730        740        750        760        770        780 
STFSNSMMMS ARRPSIENLT IDASKVLVPI LNQSTMILKN SKNGQARNDT MPPNGSMRRS 


QN 

References and documentation are available.

Number of amino acids: 782

Molecular weight: 88711.66

Theoretical pI: 5.97

Amino acid composition: 
Ala (A)  47	  6.0%
Arg (R)  65	  8.3%
Asn (N)  40	  5.1%
Asp (D)  44	  5.6%
Cys (C)   7	  0.9%
Gln (Q)  36	  4.6%
Glu (E)  84	 10.7%
Gly (G)  41	  5.2%
His (H)  14	  1.8%
Ile (I)  49	  6.3%
Leu (L)  59	  7.5%
Lys (K)  53	  6.8%
Met (M)  20	  2.6%
Phe (F)  22	  2.8%
Pro (P)  24	  3.1%
Ser (S)  70	  9.0%
Thr (T)  45	  5.8%
Trp (W)   2	  0.3%
Tyr (Y)  15	  1.9%
Val (V)  45	  5.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 128
Total number of positively charged residues (Arg + Lys): 118

Atomic composition:

Carbon      C	      3810
Hydrogen    H	      6204
Nitrogen    N	      1136
Oxygen      O	      1245
Sulfur      S	        27

Formula: C3810H6204N1136O1245S27
Total number of atoms: 12422

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    33725
Abs 0.1% (=1 g/l)   0.380, assuming all pairs of Cys residues form cystines


Ext. coefficient    33350
Abs 0.1% (=1 g/l)   0.376, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 49.87
This classifies the protein as unstable.



Aliphatic index: 76.56

Grand average of hydropathicity (GRAVY): -0.750