ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVEQDNGFLQ KLLKTQYDAV FHLKDENGIE IYPIFNVLPP KKEYPDYYII IRNPISLNTL 

        70         80         90        100        110        120 
KKRLPHYTSP QDFVNDFAQI PWNAMTYNAK DSVIYKYAIL LESFIKGKIV HNIRKHYPEV 

       130        140        150        160        170        180 
TYPSLGRIPE IFAESMQPSD LSSNPINTQE NDEKAGLNPE MKMAFAKLDS SITERKPTNQ 

       190        200        210        220        230        240 
DYRMQQKNSP AFPTHSASIT PQPLASPTPV VNYANITSAH PKTHVRRGRP PVIDLPYVLR 

       250        260        270        280        290        300 
IKNILKMMRR EVDQNNKTLT LCFEKLPDRN EEPTYYSVIT DPICLMDIRK KVKSRKYRNF 

       310        320        330        340        350        360 
HTFEEDFQLM LTNFKLYYSQ DQSNIIRAQL LEKNFNRLVR IELSKPDEDY LPEGELRYPL 

       370        380        390        400        410        420 
DDVEINDEKY QIGDWVLLHN PNDINKPIVG QIFRLWSTTD GNKWLNACWY FRPEQTVHRV 

       430        440        450        460        470        480 
DRLFYKNEVM KTGQYRDHPI QDIKGKCYVI HFTRFQRGDP STKVNGPQFV CEFRYNESDK 

       490        500        510        520        530        540 
VFNKIRTWKA CLPEELRDQD EPTIPVNGRK FFKYPSPIAD LLPANATLND KVPEPTEGAP 

       550        560        570        580        590        600 
TAPPLVGAVY LGPKLERDDL GEYSTSDDCP RYIIRPNDPP EEGKIDYETG TIITDTLTTS 

       610        620        630        640        650        660 
SMPRVNSSST IRLPTLKQTK SIPSSNFRSS SNTPLLHQNF NQTSNFLKLE NMNNSSHNLL 

       670        680        690        700        710        720 
SHPSVPKFQS PSLLEQSSRS KYHSAKKQTQ LSSTAPKKPA SKSFTLSSMI NTLTAHTSKY 

       730        740        750        760        770        780 
NFNHIVIEAP GAFVVPVPME KNIRTIQSTE RFSRSNLKNA QNLGNTAIND INTANEQIIW 

       790        800        810        820        830        840 
FKGPGVKITE RVIDSGNDLV RVPLNRWFCK NKRRKLDYED IEEDVMEPPN DFSEDMIANI 

       850        860        870        880        890        900 
FNPPPSLNLD MDLNLSPSSN NSSNFMDLST IASGDNDGKE CDTAEESEDE NEDTEDEHEI 

       910        920 
EDIPTTSAFG LNSSAEYLAF RLREFNKL 

References and documentation are available.

Number of amino acids: 928

Molecular weight: 106669.34

Theoretical pI: 6.10

Amino acid composition: 
Ala (A)  38	  4.1%
Arg (R)  48	  5.2%
Asn (N)  76	  8.2%
Asp (D)  60	  6.5%
Cys (C)   9	  1.0%
Gln (Q)  34	  3.7%
Glu (E)  63	  6.8%
Gly (G)  29	  3.1%
His (H)  19	  2.0%
Ile (I)  63	  6.8%
Leu (L)  74	  8.0%
Lys (K)  65	  7.0%
Met (M)  19	  2.0%
Phe (F)  41	  4.4%
Pro (P)  74	  8.0%
Ser (S)  73	  7.9%
Thr (T)  58	  6.2%
Trp (W)   8	  0.9%
Tyr (Y)  36	  3.9%
Val (V)  41	  4.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 123
Total number of positively charged residues (Arg + Lys): 113

Atomic composition:

Carbon      C	      4744
Hydrogen    H	      7391
Nitrogen    N	      1293
Oxygen      O	      1452
Sulfur      S	        28

Formula: C4744H7391N1293O1452S28
Total number of atoms: 14908

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    98140
Abs 0.1% (=1 g/l)   0.920, assuming all pairs of Cys residues form cystines


Ext. coefficient    97640
Abs 0.1% (=1 g/l)   0.915, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 50.55
This classifies the protein as unstable.



Aliphatic index: 74.48

Grand average of hydropathicity (GRAVY): -0.701