Home  |  Contact

ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVGERYRSHH AVDPSDAQEK EVLDHYELNR EKYNDERDNV QKKTFTKWVN KHLSKTDHKI 

        70         80         90        100        110        120 
DDLFVDLRDG YALIALLEAL TGERIQKENG YTRFHRIQNV QYCLDFLKKK NIKLVNIRPE 

       130        140        150        160        170        180 
DIVEGNGKLT LGLIWTIILN FQVSVIRQRL LLESSQHEQM SAKHTTTNSQ VSLHGSDATS 

       190        200        210        220        230        240 
ARDALLQWAR RVTAGYPRVN VNNFSSSWRD GLAFNAILHR YRSSAIDWNK ISSDSVSNTE 

       250        260        270        280        290        300 
RLNNAFAAAD REFGVERLLD AEDVDTNNPD EKSIITYVSS LYNALPHEPE MSRLQKVQEE 

       310        320        330        340        350        360 
YIEEAYEWRE WVVRAIQLVD DRHLQGTASE LIYELQRFRE DDLPPREEQK RRLTLVYEHL 

       370        380        390        400        410        420 
EKVMRSTELF AIPHELSAPE LQRVWNELQN SIDRRFDVLE RHRIQEGNSN DLLSRLARGI 

       430        440        450        460        470        480 
GITNEKLDLI LKRIEDVEAR VDTSPPAAVE RTVSEIVDDL NALESPIARF FEDVEELKSM 

       490        500        510        520        530        540 
QHPEANDFYK QVYGLHQRRT TYLDRLTNQI LVRLGVRTDS LHKENQQRLE NMRKTSFSRV 

       550        560        570        580        590        600 
EECIEWVRVR MEKLTTMEFL EDLETLEHVF EQHKFDNRDI QDFRQNVDEC IARQAEVSAE 

       610        620        630        640        650        660 
DTYEYCELLR VLESEYQQLR DLSAGRMLDL DSLIAFVRAA QLELIWVSER ESIEVTRNWS 

       670        680        690        700        710        720 
DIKQLDLPML TNYYKQLLHE MELREKQYND VHNQGAALLN QGHPAIRVIE VYLRQMQSQW 

       730        740        750        760        770        780 
DWLLALSKCL EEHLRDALNL KSFMEEASDA EAWIQEQSVR LENNYNRTDF SLEEGERFLR 

       790        800        810        820        830        840 
ELDEIKEILN KYHQVLMALT ERCASISPLW QRGERIPHPI KVTALCDYSD ENVTIKAGDD 

       850        860        870        880        890        900 
VYLLDNSDLI KWTIRDISGA EGQVPSVVFR IPPTDARLTA LLNRLLQQFE KLKKLWDKKH 

       910        920        930        940        950        960 
RMVRFNMVLN TMRTIQGWDL DTFNSIDPDQ RDAIMKALND DANKLLSELD PNDPLALRLR 

       970        980        990       1000       1010       1020 
EELRRTNEHF WNLLNASQKP PEPDWASQYD QKMAELLKKL EEAWRELNDA VGKPISRSPE 

      1030       1040       1050       1060       1070       1080 
DLERVIHAHK RFEDALQALD SDVANVKELF RQLPNPTPTQ RVNHDRLNGL WDDLWDLSRM 

      1090       1100       1110       1120       1130       1140 
YVERIKVLES VLNGMVEVAD IVRQHEITLN SFDDLPAALD KLRGHHSQLL EINMVLKQQQ 

      1150       1160       1170       1180       1190       1200 
TVIDQLNRNV ALLRQHVSRT RINEGHHPDV DAIEDEVQKL NVRWENVNSQ IASRLLAVES 

      1210       1220       1230       1240       1250       1260 
ALQIQMVYRS EYETEMSWLD TVEETINRLR KPEELRPEQY QQQLDMLIAE YTNLQEHTQA 

      1270       1280       1290       1300       1310       1320 
IEHVNKEGGR FIHEAKIFDA KLGQYSDGIV GIHGPGIKSE FRRTKPQPKN GSQIVTEELE 

      1330       1340       1350       1360       1370       1380 
LLNRRFAQLS SLILERRNTM QVLIQNWKRQ KQEEEDRRRA EEEEKRRAFE AARLKALEDA 

      1390       1400       1410       1420       1430       1440 
ERLRREREDA EARRRAKDDA DRARRMAEDA ERARREAEEA ERRRREEEER RRREAEDRKR 

      1450       1460       1470       1480       1490       1500 
RQDEEDRRRR EEEERRRREE EEKRRKKPDF DLKIQKPTMN IEPVVTSAGD EWEIVDPIGD 

      1510       1520       1530       1540       1550       1560 
RAKISEVEDE MQTFAEETIT NTQFYEMEGN LNKKTGEVLT FIEAIRQGNL TAAGQFFDIP 

      1570       1580       1590       1600       1610       1620 
SASVMSLEEA AKYGLVEQDL PTVLNTTWGI HHPETRQPIT LSEAIRIGLY DSNIRQFRDI 

      1630       1640       1650       1660       1670       1680 
HTGEILSQSD LMSKGIANWE TVLKLIKEKI MKLPPTSLAN ALEKRMVDPQ TGVFKGRTTD 

      1690       1700       1710       1720       1730       1740 
MELQLWAAIY HGYLSIENPE HVTTIGTSLT DAIENGFINA NNAEFNDRNS NDSFKLRDAV 

      1750       1760       1770       1780       1790       1800 
SKRTGLINND VVEIVQMTDD EKKRVPLGAA LVRNVIGVKD GKYTNLASRQ SMSLKEAHQD 

      1810       1820       1830       1840       1850       1860 
GLIGKALTLE EAAQNKLVDS SGYFVDRGIL GQRYTLLEAI VAGLIDAEVR HIVDPNENDV 

      1870       1880       1890       1900       1910       1920 
ISISEAMERG LLLPNGKIVL EKDEKEFTIP EAVHEGLLTK RVRHSIFNIR GIRNTETSQN 

      1930       1940       1950       1960       1970       1980 
LSFNEAVEAG VIIPNAERVV DLQTQESFLI TDDRAKNLIE VALHELLTTP VGIKNDRGAY 

      1990       2000       2010       2020       2030       2040 
ELNLVRAVSS GIIDPVKGVF FNKNTKHELS TKEAYEQGFI TLRGALKVFG LLNVPPALVT 

      2050       2060       2070       2080       2090       2100 
PAKKLDRTRR IGRPGQEGGA DGNHVTVTLQ DAMRQGLVGN QRYVHGKVDL SLEEALNRGL 

      2110       2120       2130       2140       2150       2160 
LDPNSQWIMP DQSKGDGPTI EEKTTETMTE TGQQLAPKYF PDKNIEESVT TVKRVRTTET 

      2170       2180       2190       2200       2210       2220 
TALGGPGGVS VYRSIAGGKG ALEVPSRGYH IYEAERKGLI DLTNGKISAP NVDRVLSFAE 

      2230       2240       2250       2260       2270       2280 
GIELGIIDAT TIQVSTGGRS VSVKEALEKK IMESDGSVNG RNIEQAVEAK TIVIDAEPLV 

      2290       2300       2310       2320       2330       2340 
PYNNQSKNII QIPSGNGPII SFRQVGQPVV EESTQSWEFD TQQGVFVDNL TGEKLSLERA 

      2350       2360       2370       2380       2390       2400 
LATGKVAPED ISVRDGLTGR EMPLEEAEKW GIIDSKNRYY FDKSQNKRMS YTEAAQQHLM 

      2410       2420       2430       2440       2450       2460 
YLTGGVPENA SDAVHTTVKV QTRTAVAKKE ALSSGLPLSD YSLGKALSLG WYDQSAGTFT 

      2470       2480       2490       2500       2510       2520 
HPETQKQLTL KEAIMKGLFD PYDTTIVDKK AGKEISLLEA IREEIVDDNA GTVKDTQTGR 

      2530       2540       2550       2560       2570       2580 
VHNFLEAGNL GLVKGKNFGD TLDSSLFSGR LDLGSGSYTR PSGGSSMPIH EAINRNYVDR 

      2590       2600       2610       2620       2630       2640 
SSVSVRDPSS GQQYSYQEAV DRRIVDADRG LIHGGGDSTS FSQGLTSGHL VSSGSSRPTS 

      2650       2660       2670       2680       2690       2700 
GNQSRLVEQR LQLTPFAPNG GAGRSRDGRH ELVDLGGGQQ VQVKVVRGEG GVEKGEYTDP 

      2710       2720       2730       2740       2750       2760 
KSGMKFTIQM HGDPVVTETK TSVKSTSQVH SVELEPHAEF VGIDRVRDKR NNHVYSLEEA 

      2770       2780       2790       2800       2810       2820 
RRLGLAKVDK KGKQMTRSYQ AFRSNIDNAV NNGVVDSHNQ KISLENAIHA RIIDIRNLSY 

      2830       2840       2850       2860       2870       2880 
HHPTHGSVDL KTAASQGLVD VTLSEVLPKG IIHPGTGERI DIKRGIELRI IDAATGKVRD 

      2890       2900       2910       2920       2930       2940 
PRDNKTITWI DILKPVYQAI ASEGVFDPTK GHHVPVTTAL NDGLINASTG NYRNSITGED 

      2950       2960       2970       2980       2990       3000 
VPLSDTVDRG LIDRSTYETI TKPFFTDYRS NRKLNLVEAV RERLIDPKNR TIQLSRQSIV 

      3010       3020       3030       3040       3050       3060 
PIAKAVQDGR IPMEIGEKLR KVDKLNFAEA LGKGLIDSKQ NVFTDPDTGR QMSIAQAIQE 

      3070       3080       3090       3100       3110       3120 
GFIDTGSVQG IEGNDESNLF NVLQSSDFDE TSGRIYDKKS SLHLTFNDAV RRGVIDGDSL 

      3130       3140       3150       3160       3170       3180 
LHLQATGDLL TLRDALHQNK IDSNGKFVEG ANRLKISDAV KSGRLTVIAS PSEAVQAVTE 

      3190       3200       3210       3220       3230       3240 
GVKRRDAEGY KFRISEYDDS QAQRQSVPKF RETVTVSKLT PQYNEPGLSV RMRQSTTSIG 

      3250       3260       3270       3280       3290       3300 
DRASKFLEDP SQLAEIQQDF LSSLEAAQFD TDEKVIEHPH TRQRVSVREA AETGLLDVQT 

      3310       3320       3330       3340       3350       3360 
GEIVNPDNGR RFSIPRAVHM KLVGGDAAKR IMEQLNMPVE EVAYATQTIT SSTHRAPSPV 

      3370       3380       3390       3400       3410       3420 
FATASVSQPS GGATTTREFT RTINWHGQPS ELRNSQTDPL AAYTTVSSNV TESTEDAPAW 


ARKQ


References and documentation are available. 

Number of amino acids: 3424

Molecular weight: 388253.00

Theoretical pI: 5.56


Amino acid composition: 
Ala (A) 229	  6.7%
Arg (R) 271	  7.9%
Asn (N) 171	  5.0%
Asp (D) 231	  6.7%
Cys (C)   7	  0.2%
Gln (Q) 173	  5.1%
Glu (E) 313	  9.1%
Gly (G) 200	  5.8%
His (H)  83	  2.4%
Ile (I) 202	  5.9%
Leu (L) 322	  9.4%
Lys (K) 183	  5.3%
Met (M)  56	  1.6%
Phe (F)  91	  2.7%
Pro (P) 119	  3.5%
Ser (S) 226	  6.6%
Thr (T) 201	  5.9%
Trp (W)  37	  1.1%
Tyr (Y)  76	  2.2%
Val (V) 233	  6.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%



Total number of negatively charged residues (Asp + Glu): 544
Total number of positively charged residues (Arg + Lys): 454

Atomic composition:

Carbon      C	     16944
Hydrogen    H	     27175
Nitrogen    N	      4967
Oxygen      O	      5360
Sulfur      S	        63

Formula: C16944H27175N4967O5360S63
Total number of atoms: 54509

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   317115
Abs 0.1% (=1 g/l)   0.817, assuming all pairs of Cys residues form cystines


Ext. coefficient   316740
Abs 0.1% (=1 g/l)   0.816, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 43.20
This classifies the protein as unstable.



Aliphatic index: 86.11

Grand average of hydropathicity (GRAVY): -0.622