ProtParam
User-provided sequence:
10 20 30 40 50 60
MVGERYRSHH AVDPSDAQEK EVLDHYELNR EKYNDERDNV QKKTFTKWVN KHLSKTDHKI
70 80 90 100 110 120
DDLFVDLRDG YALIALLEAL TGERIQKENG YTRFHRIQNV QYCLDFLKKK NVSVIRQRLL
130 140 150 160 170 180
LESSQHEQMS AKHTTTNSQV SLHGSDATSA RDALLQWARR VTAGYPRVNV NNFSSSWRDG
190 200 210 220 230 240
LAFNAILHRY RSSAIDWNKI SSDSVSNTER LNNAFAAADR EFGVERLLDA EDVDTNNPDE
250 260 270 280 290 300
KSIITYVSSL YNALPHEPEM SRLQKVQEEY IEEAYEWREW VVRAIQLVDD RHLQGTASEL
310 320 330 340 350 360
IYELQRFRED DLPPREEQKR RLTLVYEHLE KVMRSTELFA IPHELSAPEL QRVWNELQNS
370 380 390 400 410 420
IDRRFDVLER HRIQEGNSND LLSRLARGIG ITNEKLDLIL KRIEDVEARV DTSPPAAVER
430 440 450 460 470 480
TVSEIVDDLN ALESPIARFF EDVEELKSMQ HPEANDFYKQ VYGLHQRRTT YLDRLTNQIL
490 500 510 520 530 540
VRLGVRTDSL HKENQQRLEN MRKTSFSRVE ECIEWVRVRM EKLTTMEFLE DLETLEHVFE
550 560 570 580 590 600
QHKFDNRDIQ DFRQNVDECI ARQAEVSAED TYEYCELLRV LESEYQQLRD LSAGRMLDLD
610 620 630 640 650 660
SLIAFVRAAQ LELIWVSERE SIEVTRNWSD IKQLDLPMLT NYYKQLLHEM ELREKQYNDV
670 680 690 700 710 720
HNQGAALLNQ GHPAIRVIEV YLRQMQSQWD WLLALSKCLE EHLRDALNLK SFMEEASDAE
730 740 750 760 770 780
AWIQEQSVRL ENNYNRTDFS LEEGERFLRE LDEIKEILNK YHQVLMALTE RCASISPLWQ
790 800 810 820 830 840
RGERIPHPIK VTALCDYSDE NVTIKAGDDV YLLDNSDLIK WTIRDISGAE GQVPSVVFRI
850 860 870 880 890 900
PPTDARLTAL LNRLLQQFEK LKKLWDKKHR MVRFNMVLNT MRTIQGWDLD TFNSIDPDQR
910 920 930 940 950 960
DAIMKALNDD ANKLLSELDP NDPLALRLRE ELRRTNEHFW NLLNASQKPP EPDWASQYDQ
970 980 990 1000 1010 1020
KMAELLKKLE EAWRELNDAV GKPISRSPED LERVIHAHKR FEDALQALDS DVANVKELFR
1030 1040 1050 1060 1070 1080
QLPNPTPTQR VNHDRLNGLW DDLWDLSRMY VERIKVLESV LNGMVEVADI VRQHEITLNS
1090 1100 1110 1120 1130 1140
FDDLPAALDK LRGHHSQLLE INMVLKVSKL GAQNEHFSQQ QTVIDQLNRN VALLRQHVSR
1150 1160 1170 1180 1190 1200
TRINEGHHPD VDAIEDEVQK LNVRWENVNS QIASRLLAVE SALQIQMVYR SEYETEMSWL
1210 1220 1230 1240 1250 1260
DTVEETINRL RKPEELRPEQ YQQQLDMLIA EYTNLQEHTQ AIEHVNKEGG RFIHEAKIFD
1270 1280 1290 1300 1310 1320
AKLGQYSDGI VGIHGPGIKS EFRRTKPQPK NGSQIVTEEL ELLNRRFAQL SSLILERRNT
1330 1340 1350 1360 1370 1380
MQVLIQNWKR QKQEEEDRRR AEEEEKRRAF EAARLKALED AERLRRERED AEARRRAKDD
1390 1400 1410 1420 1430 1440
ADRARRMAED AERARREAEE AERRRREEEE RRRREAEDRK RRQDEEDRRR REEEERRRRE
1450 1460 1470 1480 1490 1500
EEEKRRKKPD FDLKIQKPTM NIEPVVTSAG DEWEIVDPIG DRAKISEVED EMQTFAEETI
1510 1520 1530 1540 1550 1560
TNTQFYEMEG NLNKKTGEVL TFIEAIRQGN LTAAGQFFDI PSASVMSLEE AAKYGLVEQD
1570 1580 1590 1600 1610 1620
LPTVLNTTWG IHHPETRQPI TLSEAIRIGL YDSNIRQFRD IHTGEILSQS DLMSKGIANW
1630 1640 1650 1660 1670 1680
ETVLKLIKEK IMKLPPTSLA NALEKRMVDP QTGVFKGRTT DMELQLWAAI YHGYLSIENP
1690 1700 1710 1720 1730 1740
EHVTTIGTSL TDAIENGFIN ANNAEFNDRN SNDSFKLRDA VSKRTGLINN DVVEIVQMTD
1750 1760 1770 1780 1790 1800
DEKKRVPLGA ALVRNVIGVK DGKYTNLASR QSMSLKEAHQ DGLIGKALTL EEAAQNKLVD
1810 1820 1830 1840 1850 1860
SSGYFVDRGI LGQRYTLLEA IVAGLIDAEV RHIVDPNEND VISISEAMER GLLLPNGKIV
1870 1880 1890 1900 1910 1920
LEKDEKEFTI PEAVHEGLLT KRVRHSIFNI RGIRNTETSQ NLSFNEAVEA GVIIPNAERV
1930 1940 1950 1960 1970 1980
VDLQTQESFL ITDDRAKNLI EVALHELLTT PVGIKNDRGA YELNLVRAVS SGIIDPVKGV
1990 2000 2010 2020 2030 2040
FFNKNTKHEL STKEAYEQGF ITLRGALKVF GLLNVPPALV TPAKKLDRTR RIGRPGQEGG
2050 2060 2070 2080 2090 2100
ADGNHVTVTL QDAMRQGLVG NQRYVHGKVD LSLEEALNRG LLDPNSQWIM PDQSKGDGPT
2110 2120 2130 2140 2150 2160
IEEKTTETMT ETGQQLAPKY FPDKNIEESV TTVKRVRTTE TTALGGPGGV SVYRSIAGGK
2170 2180 2190 2200 2210 2220
GALEVPSRGY HIYEAERKGL IDLTNGKISA PNVDRVLSFA EGIELGIIDA TTIQVSTGGR
2230 2240 2250 2260 2270 2280
SVSVKEALEK KIMESDGSVN GRNIEQAVEA KTIVIDAEPL VPYNNQSKNI IQIPSGNGPI
2290 2300 2310 2320 2330 2340
ISFRQVGQPV VEESTQSWEF DTQQGVFVDN LTGEKLSLER ALATGKVAPE DISVRDGLTG
2350 2360 2370 2380 2390 2400
REMPLEEAEK WGIIDSKNRY YFDKSQNKRM SYTEAAQQHL MYLTGGVPEN ASDAVHTTVK
2410 2420 2430 2440 2450 2460
VQTRTAVAKK EALSSGLPLS DYSLGKALSL GWYDQSAGTF THPETQKQLT LKEAIMKGLF
2470 2480 2490 2500 2510 2520
DPYDTTIVDK KAGKEISLLE AIREEIVDDN AGTVKDTQTG RVHNFLEAGN LGLVKGKNFG
2530 2540 2550 2560 2570 2580
DTLDSSLFSG RLDLGSGSYT RPSGGSSMPI HEAINRNYVD RSSVSVRDPS SGQQYSYQEA
2590 2600 2610 2620 2630 2640
VDRRIVDADR GLIHGGGDST SFSQGLTSGH LVSSGSSRPT SGNQSRLVEQ RLQLTPFAPN
2650 2660 2670 2680 2690 2700
GGAGRSRDGR HELVDLGGGQ QVQVKVVRGE GGVEKGEYTD PKSGMKFTIQ MHGDPVVTET
2710 2720 2730 2740 2750 2760
KTSVKSTSQV HSVELEPHAE FVGIDRVRDK RNNHVYSLEE ARRLGLAKVD KKGKQMTRSY
2770 2780 2790 2800 2810 2820
QAFRSNIDNA VNNGVVDSHN QKISLENAIH ARIIDIRNLS YHHPTHGSVD LKTAASQGLV
2830 2840 2850 2860 2870 2880
DVTLSEVLPK GIIHPGTGER IDIKRGIELR IIDAATGKVR DPRDNKTITW IDILKPVYQA
2890 2900 2910 2920 2930 2940
IASEGVFDPT KGHHVPVTTA LNDGLINAST GNYRNSITGE DVPLSDTVDR GLIDRSTYET
2950 2960 2970 2980 2990 3000
ITKPFFTDYR SNRKLNLVEA VRERLIDPKN RTIQLSRQSI VPIAKAVQDG RIPMEIGEKL
3010 3020 3030 3040 3050 3060
RKVDKLNFAE ALGKGLIDSK QNVFTDPDTG RQMSIAQAIQ EGFIDTGSVQ GIEGNDESNL
3070 3080 3090 3100 3110 3120
FNVLQSSDFD ETSGRIYDKK SSLHLTFNDA VRRGVIDGDS LLHLQATGDL LTLRDALHQN
3130 3140 3150 3160 3170 3180
KIDSNGKFVE GANRLKISDA VKSGRLTVIA SPSEAVQAVT EGVKRRDAEG YKFRISEYDD
3190 3200 3210 3220 3230 3240
SQAQRQSVPK FRETVTVSKL TPQYNEPGLS VRMRQSTTSI GDRASKFLED PSQLAEIQQD
3250 3260 3270 3280 3290 3300
FLSSLEAAQF DTDEKVIEHP HTRQRVSVRE AAETGLLDVQ TGEIVNPDNG RRFSIPRAVH
3310 3320 3330 3340 3350 3360
MKLVGGDAAK RIMEQLNMPV EEVAYATQTI TSSTHRAPSP VFATASVSQP SGGATTTREF
3370 3380 3390 3400
TRTINWHGQP SELRNSQTDP LAAYTTVSSN VTESTEDAPA WARKQ
References and
documentation are available.
Number of amino acids: 3405
Molecular weight: 386048.24
Theoretical pI: 5.56
Total number of negatively charged residues (Asp + Glu): 542
Total number of positively charged residues (Arg + Lys): 452
Atomic composition:
Carbon C 16837
Hydrogen H 26993
Nitrogen N 4943
Oxygen O 5335
Sulfur S 63
Formula: C
16837H
26993N
4943O
5335S
63
Total number of atoms: 54171
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 311615
Abs 0.1% (=1 g/l) 0.807, assuming all pairs of Cys residues form cystines
Ext. coefficient 311240
Abs 0.1% (=1 g/l) 0.806, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 43.07
This classifies the protein as unstable.
Aliphatic index: 85.39
Grand average of hydropathicity (GRAVY): -0.632