ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVGQQYSSAP LRTVKEVQFG LFSPEEVRAI SVAKIRFPET MDETQTRAKI GGLNDPRLGS 

        70         80         90        100        110        120 
IDRNLKCQTC QEGMNECPGH FGHIDLAKPV FHVGFIAKIK KVCECVCMHC GKLLLDEHNE 

       130        140        150        160        170        180 
LMRQALAIKD SKKRFAAIWT LCKTKMVCET DVPSEDDPTQ LVSRGGCGNT QPTIRKDGLK 

       190        200        210        220        230        240 
LVGSWKKDRA TGDADEPELR VLSTEEILNI FKHISVKDFT SLGFNEVFSR PEWMILTCLP 

       250        260        270        280        290        300 
VPPPPVRPSI SFNESQRGED DLTFKLADIL KANISLETLE HNGAPHHAIE EAESLLQFHV 

       310        320        330        340        350        360 
ATYMDNDIAG QPQALQKSGR PVKSIRARLK GKEGRIRGNL MGKRVDFSAR TVISGDPNLE 

       370        380        390        400        410        420 
LDQVGVPKSI AKTLTYPEVV TPYNIDRLTQ LVRNGPNEHP GAKYVIRDSG DRIDLRYSKR 

       430        440        450        460        470        480 
AGDIQLQYGW KVERHIMDND PVLFNRQPSL HKMSMMAHRV KVIPYSTFRL NLSVTSPYNA 

       490        500        510        520        530        540 
DFDGDEMNLH VPQSEETRAE LSQLCAVPLQ IVSPQSNKPC MGIVQDTLCG IRKLTLRDTF 

       550        560        570        580        590        600 
IELDQVLNML YWVPDWDGVI PTPAIIKPKP LWSGKQILSV AIPNGIHLQR FDEGTTLLSP 

       610        620        630        640        650        660 
KDNGMLIIDG QIIFGVVEKK TVGSSNGGLI HVVTREKGPQ VCAKLFGNIQ KVVNFWLLHN 

       670        680        690        700        710        720 
GFSTGIGDTI ADGPTMREIT ETIAEAKKKV LDVTKEAQAN LLTAKHGMTL RESFEDNVVR 

       730        740        750        760        770        780 
FLNEARDKAG RLAEVNLKDL NNVKQMVMAG SKGSFINIAQ MSACVGQQSV EGKRIAFGFV 

       790        800        810        820        830        840 
DRTLPHFSKD DYSPESKGFV ENSYLRGLTP QEFFFHAMGG REGLIDTAVK TAETGYIQRR 

       850        860        870        880        890        900 
LVKALEDIMV HYDNTTRNSL GNVIQFIYGE DGMDAAHIEK QSLDTIGGSD AAFEKRYRVD 

       910        920        930        940        950        960 
LLNTDHTLDP SLLESGSEIL GDLKLQVLLD EEYKQLVKDR KFLREVFVDG EANWPLPVNI 

       970        980        990       1000       1010       1020 
RRIIQNAQQT FHIDHTKPSD LTIKDIVLGV KDLQENLLVL RGKNEIIQNA QRDAVTLFCC 

      1030       1040       1050       1060       1070       1080 
LLRSRLATRR VLQEYRLTKQ AFDWVLSNIE AQFLRSVVHP GEMVGVLAAQ SIGEPATQMT 

      1090       1100       1110       1120       1130       1140 
LNTFHFAGVA SKKVTSGVPR LKEILNVAKN MKTPSLTVYL EPGHAADQEQ AKLIRSAIEH 

      1150       1160       1170       1180       1190       1200 
TTLKSVTIAS EIYYDPDPRS TVIPEDEEII QLHFSLLDEE AEQSFDQQSP WLLRLELDRA 

      1210       1220       1230       1240       1250       1260 
AMNDKDLTMG QVGERIKQTF KNDLFVIWSE DNDEKLIIRC RVVRPKSLDA ETEAEEDHML 

      1270       1280       1290       1300       1310       1320 
KKIENTMLEN ITLRGVENIE RVVMMKYDRK VPSPTGEYVK EPEWVLETDG VNLSEVMTVP 

      1330       1340       1350       1360       1370       1380 
GIDPTRIYTN SFIDIMEVLG IEAGRAALYK EVYNVIASDG SYVNYRHMAL LVDVMTTQGG 

      1390       1400       1410       1420       1430       1440 
LTSVTRHGFN RSNTGALMRC SFEETVEILF EAGASAELDD CRGVSENVIL GQMAPIGTGA 

      1450       1460       1470       1480       1490       1500 
FDVMIDEESL VKYMPEQKIT EIEDGQDGGV TPYSNESGLV NADLDVKDEL MFSPLVDSGS 

      1510       1520       1530       1540       1550       1560 
NDAMAGGFTA YGGADYGEAT SPFGAYGEAP TSPGFGVSSP GFSPTSPTYS PTSPAYSPTS 

      1570       1580       1590       1600       1610       1620 
PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP TSPSYSPTSP SYSPTSPSYS 

      1630       1640       1650       1660       1670       1680 
PTSPSYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPA YSPTSPSYSP TSPSYSPTSP 

      1690       1700       1710       1720       1730 
SYSPTSPSYS PTSPNYSPTS PSYSPTSPGY SPGSPAYSPK QDEQKHNENE NSR 

References and documentation are available.

Number of amino acids: 1733

Molecular weight: 191611.63

Theoretical pI: 5.42

Amino acid composition: 
Ala (A)  98	  5.7%
Arg (R)  83	  4.8%
Asn (N)  71	  4.1%
Asp (D) 102	  5.9%
Cys (C)  21	  1.2%
Gln (Q)  66	  3.8%
Glu (E) 117	  6.8%
Gly (G) 115	  6.6%
His (H)  35	  2.0%
Ile (I)  97	  5.6%
Leu (L) 143	  8.3%
Lys (K)  93	  5.4%
Met (M)  44	  2.5%
Phe (F)  58	  3.3%
Pro (P) 124	  7.2%
Ser (S) 163	  9.4%
Thr (T) 115	  6.6%
Trp (W)  13	  0.8%
Tyr (Y)  58	  3.3%
Val (V) 117	  6.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 219
Total number of positively charged residues (Arg + Lys): 176

Atomic composition:

Carbon      C	      8461
Hydrogen    H	     13333
Nitrogen    N	      2295
Oxygen      O	      2645
Sulfur      S	        65

Formula: C8461H13333N2295O2645S65
Total number of atoms: 26799

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   159170
Abs 0.1% (=1 g/l)   0.831, assuming all pairs of Cys residues form cystines


Ext. coefficient   157920
Abs 0.1% (=1 g/l)   0.824, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 55.27
This classifies the protein as unstable.



Aliphatic index: 79.24

Grand average of hydropathicity (GRAVY): -0.398