ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVGSGSHTPY DISNSPSDVN VQPATQLNST LVEDDDVDNQ LFEEAQVTET GFRSPSASDN 

        70         80         90        100        110        120 
SCAYCGIDSA KCVIKCNSCK KWFCNTKNGT SSSHIVNHLV LSHHNVVSLH PDSDLGDTVL 

       130        140        150        160        170        180 
ECYNCGRKNV FLLGFVSAKS EAVVVLLCRI PCAQTKNANW DTDQWQPLIE DRQLLSWVAE 

       190        200        210        220        230        240 
QPTEEEKLKA RLITPSQISK LEAKWRSNKD ATINDIDAPE EQEAIPPLLL RYQDAYEYQR 

       250        260        270        280        290        300 
SYGPLIKLEA DYDKQLKESQ ALEHISVSWS LALNNRHLAS FTLSTFESNE LKVAIGDEMI 

       310        320        330        340        350        360 
LWYSGMQHPD WEGRGYIVRL PNSFQDTFTL ELKPSKTPPP THLTTGFTAE FIWKGTSYDR 

       370        380        390        400        410        420 
MQDALKKFAI DKKSISGYLY YKILGHQVVD ISFDVPLPKE FSIPNFAQLN SSQSNAVSHV 

       430        440        450        460        470        480 
LQRPLSLIQG PPGTGKTVTS ATIVYHLSKI HKDRILVCAP SNVAVDHLAA KLRDLGLKVV 

       490        500        510        520        530        540 
RLTAKSREDV ESSVSNLALH NLVGRGAKGE LKNLLKLKDE VGELSASDTK RFVKLVRKTE 

       550        560        570        580        590        600 
AEILNKADVV CCTCVGAGDK RLDTKFRTVL IDESTQASEP ECLIPIVKGA KQVILVGDHQ 

       610        620        630        640        650        660 
QLGPVILERK AADAGLKQSL FERLISLGHV PIRLEVQYRM NPYLSEFPSN MFYEGSLQNG 

       670        680        690        700        710        720 
VTIEQRTVPN SKFPWPIRGI PMMFWANYGR EEISANGTSF LNRIEAMNCE RIITKLFRDG 

       730        740        750        760        770        780 
VKPEQIGVIT PYEGQRAYIL QYMQMNGSLD KDLYIKVEVA SVDAFQGREK DYIILSCVRA 

       790        800        810        820        830        840 
NEQQAIGFLR DPRRLNVGLT RAKYGLVILG NPRSLARNTL WNHLLIHFRE KGCLVEGTLD 

       850        860        870        880        890        900 
NLQLCTVQLV RPQPRKTERP MNAQFNVESE MGDFPKFQDF DAQSMVSFSG QIGDFGNAFV 

       910        920        930        940        950        960 
DNTELSSYIN NEYWNFENFK SAFSQKQNRN EIDDRNLYQE EASHLNSNFA RELQREEQKH 

       970 
ELSKDFSNLG I 

References and documentation are available.

Number of amino acids: 971

Molecular weight: 109430.15

Theoretical pI: 6.06

Amino acid composition: 
Ala (A)  59	  6.1%
Arg (R)  49	  5.0%
Asn (N)  57	  5.9%
Asp (D)  55	  5.7%
Cys (C)  19	  2.0%
Gln (Q)  50	  5.1%
Glu (E)  66	  6.8%
Gly (G)  53	  5.5%
His (H)  22	  2.3%
Ile (I)  54	  5.6%
Leu (L)  99	 10.2%
Lys (K)  60	  6.2%
Met (M)  14	  1.4%
Phe (F)  39	  4.0%
Pro (P)  44	  4.5%
Ser (S)  80	  8.2%
Thr (T)  45	  4.6%
Trp (W)  13	  1.3%
Tyr (Y)  28	  2.9%
Val (V)  65	  6.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 121
Total number of positively charged residues (Arg + Lys): 109

Atomic composition:

Carbon      C	      4853
Hydrogen    H	      7642
Nitrogen    N	      1342
Oxygen      O	      1474
Sulfur      S	        33

Formula: C4853H7642N1342O1474S33
Total number of atoms: 15344

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   114345
Abs 0.1% (=1 g/l)   1.045, assuming all pairs of Cys residues form cystines


Ext. coefficient   113220
Abs 0.1% (=1 g/l)   1.035, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 34.89
This classifies the protein as stable.



Aliphatic index: 86.94

Grand average of hydropathicity (GRAVY): -0.388