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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVLADLGKRI NSAVNNAISN TQDDFTTSVD VMLKGIVTAL LESDVNIALV SKLRNNIRSQ

70 80 90 100 110 120
LLSENRSEKS TTNAQTKKLI QKTVFDELCK LVTCEGSEEK AFVPKKRKTN IIMFVGLQGS

130 140 150 160 170 180
GKTTSCTKLA VYYSKRGFKV GLVCADTFRA GAFDQLKQNA IRARIPFYGS YTETDPAKVA

190 200 210 220 230 240
EEGINKFKKE KFDIIIVDTS GRHHQEEELF QEMIEISNVI KPNQTIMVLD ASIGQAAEQQ

250 260 270 280 290 300
SKAFKESSDF GAIILTKMDG HARGGGAISA VAATNTPIIF IGTGEHIHDL EKFSPKSFIS

310 320 330 340 350 360
KLLGIGDIES LFEQLQTVSN KEDAKATMEN IQKGKFTLLD FKKQMQTIMK MGPLSNIAQM

370 380 390 400 410 420
IPGMSNMMNQ VGEEETSQKM KKMVYVLDSM TKEELESDGR MFIEEPTRMV RVAKGSGTSV

430 440 450 460 470 480
FEVEMILMQQ QMMARMAQTA TQQQPGAPGA NARMPGMPNM PGMPNMPGMP NMPGMPKVTP

490 500 510 520 530 540
QMMQQAQQKL KQNPGLMQNM MNMFGGGMGG GMGGGMPDMN EMMKMMQDPQ MQQMAKQFGM


G


References and documentation are available.

Number of amino acids: 541 Molecular weight: 59624.27 Theoretical pI: 8.73
Amino acid composition: 
Ala (A) 37 6.8% Arg (R) 16 3.0% Asn (N) 28 5.2% Asp (D) 22 4.1% Cys (C) 4 0.7% Gln (Q) 40 7.4% Glu (E) 35 6.5% Gly (G) 47 8.7% His (H) 5 0.9% Ile (I) 35 6.5% Leu (L) 32 5.9% Lys (K) 46 8.5% Met (M) 49 9.1% Phe (F) 23 4.3% Pro (P) 23 4.3% Ser (S) 33 6.1% Thr (T) 33 6.1% Trp (W) 0 0.0% Tyr (Y) 5 0.9% Val (V) 28 5.2% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 57 Total number of positively charged residues (Arg + Lys): 62 Atomic composition: Carbon C 2579 Hydrogen H 4209 Nitrogen N 713 Oxygen O 795 Sulfur S 53 Formula: C2579H4209N713O795S53 Total number of atoms: 8349 Extinction coefficients: This protein does not contain any Trp residues. Experience shows that this could result in more than 10% error in the computed extinction coefficient. Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 7700 Abs 0.1% (=1 g/l) 0.129, assuming all pairs of Cys residues form cystines Ext. coefficient 7450 Abs 0.1% (=1 g/l) 0.125, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 48.42 This classifies the protein as unstable. Aliphatic index: 70.15 Grand average of hydropathicity (GRAVY): -0.343