ProtParam
User-provided sequence:
10 20 30 40 50 60
MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR KNKNANPEGV
70 80 90 100 110 120
CTCGRLEKKK LAQKAKEEAR AKAKEKQRKQ CTCGTDEVCK YHAQKRHLRK SPSSSQKKGR
130 140 150 160 170 180
SISRSQPMFE RVLSSTSLDS NMLSGHGALS DTSSILTSTF LDSEPGVGKI SKDYHHVPSL
190 200 210 220 230 240
ASISSLQSSQ SLDQNFSIPQ SPPLSSMSFN FLTGNINETN QNHSNHQHSK SGNNWQDSSV
250 260 270 280 290 300
SLPAKADSRL NMMDKNNSVG LDLLGHSKRI SPISNSRVGE VSVPLEEYIP SDIDGVGRVT
310 320 330 340 350 360
DKSSLVYDWP FDESIERNFS TTATAATGES KFDINDNCNR INSKSYSKTN SMNGNGMNNS
370 380 390 400 410 420
NNNNINSNGN DKNNNNSSRQ EHQGNGLFDM FTDSSSISTL SRANLLLQEK IGSQENSVKQ
430 440 450 460 470 480
ENYSKNPQLR HQLTSRSRSF IHHPANEYLK NTFGNSHSND IGKGVEVLSL TPSFMDIPEK
490 500 510 520 530 540
ERETERSPSS NYITDRPFTR KPRSSSIDVN HRYPPMAPTT VATSPGALNN AVASNLDDQL
550 560 570 580 590 600
SLTSLNSQPS SIANMMMDPS NLAEQSSIHS VPQSINSPRM PKTGSRQDKN IHTKKEERNP
610 620 630 640 650 660
LNNIHDLSQL ENVPDEMNQM FSPPLKSMNR PDAIRENSSS SNFIIQGNSM ISTPSGRNDL
670 680 690
PDTSPMSSIQ TASPPSQLLT DQGFADLDNF MSSL
References and
documentation are available.
Number of amino acids: 694
Molecular weight: 76670.99
Theoretical pI: 8.84
Total number of negatively charged residues (Asp + Glu): 70
Total number of positively charged residues (Arg + Lys): 79
Atomic composition:
Carbon C 3240
Hydrogen H 5206
Nitrogen N 990
Oxygen O 1097
Sulfur S 34
Formula: C
3240H
5206N
990O
1097S
34
Total number of atoms: 10567
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 28015
Abs 0.1% (=1 g/l) 0.365, assuming all pairs of Cys residues form cystines
Ext. coefficient 27390
Abs 0.1% (=1 g/l) 0.357, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 54.82
This classifies the protein as unstable.
Aliphatic index: 60.71
Grand average of hydropathicity (GRAVY): -0.864