ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVLMEDMQNK DGHNTVENSS GGTDSNNNIQ MRRMRKTQLS KKELFEKRKS DVLIAAKSLD 

        70         80         90        100        110        120 
TEIQNVKNLK RLSIGSMDLV IDPELEFKVN SRNSYSSDSS KESLQESLHE ENIIRSEQKE 

       130        140        150        160        170        180 
EQGSEDNDAY EEGDATNVDD SIDITQTEYL HDEETLEKEK IIRNASSSTS SSARVTSRNR 

       190        200        210        220        230        240 
RLSGVKTLAH DVVLDVENDH DSKMVDLTQN LLWVPADQHP NVKPENYLEL IQDTLQNIQI 

       250        260        270        280        290        300 
STNQDIDENK LELGNNHVIS NRKRTGSVVR RPSRLKTSYT KFDDEPPLAD KPQEGEIQVD 

       310        320        330        340        350        360 
KRISSSDIKT IRSVSLKEIT EELTKISNNA GLTDSDAVTL ARSLSMSGSF TNESLHLNGN 

       370        380        390        400        410        420 
HTENDNEFAS NMFNETGLTI PERSSLRRSK FNTYKIRLEG SSLPQAVKLN SLMNIQTNDN 

       430        440        450        460        470        480 
RRSASSPASY TQVPQEQASL NDFHEIFDHY RRTSTDWSTE NEKYVDSTNY YSDEEDLTHA 

       490        500        510        520        530        540 
SISQESSLLS TDSSNNSVLI KPHNTGSMIS EKLDQHVSSS EKSNTNNSEA NHGWSWLNSS 

       550        560        570        580        590        600 
NGSLNANEQT YQQLTDDEDD EECVDNEKAD FVNLSVSRRA KSTKRASERI NHSKNRHSPI 

       610        620        630        640        650        660 
FQIHSEEAKS VVITPSVVSS SESQPSKPTA PAVVEKKVEL PTDTQASTHK KNSLEKRLAK 

       670        680        690        700        710        720 
LFKRKQHNGT CKSDVKVIKK SVKKELKKKA SHSSLSKFRK SPKKKPQEAE VERPSSPTKT 

       730        740        750        760        770        780 
ITTEDIDTAS VIEPEVRSSN ASTLLPDSHT SHSSEFVVET ISELDGDDSF DISGGDVNYD 

       790        800        810        820        830        840 
VEVHSSISRD TTAGLEEDIG AEREDNTSPT APQISTLPPR KLTFEDVVKP DYSNAPIKFT 

       850        860        870        880        890        900 
DSAFGFPLPM ITNSTVIMFD HRLGINVERA IYRLSHLKLS DPGRELRQQV LLSNFMYSYL 

       910        920        930        940 
NLVNHTLYME QVGTGDIAFN GDSALGMMDK NDSDGTILIP DI 

References and documentation are available.

Number of amino acids: 942

Molecular weight: 105496.12

Theoretical pI: 5.22

Amino acid composition: 
Ala (A)  40	  4.2%
Arg (R)  46	  4.9%
Asn (N)  70	  7.4%
Asp (D)  72	  7.6%
Cys (C)   2	  0.2%
Gln (Q)  35	  3.7%
Glu (E)  80	  8.5%
Gly (G)  32	  3.4%
His (H)  27	  2.9%
Ile (I)  51	  5.4%
Leu (L)  74	  7.9%
Lys (K)  67	  7.1%
Met (M)  17	  1.8%
Phe (F)  22	  2.3%
Pro (P)  35	  3.7%
Ser (S) 130	 13.8%
Thr (T)  66	  7.0%
Trp (W)   4	  0.4%
Tyr (Y)  18	  1.9%
Val (V)  54	  5.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 152
Total number of positively charged residues (Arg + Lys): 113

Atomic composition:

Carbon      C	      4511
Hydrogen    H	      7244
Nitrogen    N	      1310
Oxygen      O	      1566
Sulfur      S	        19

Formula: C4511H7244N1310O1566S19
Total number of atoms: 14650

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    48945
Abs 0.1% (=1 g/l)   0.464, assuming all pairs of Cys residues form cystines


Ext. coefficient    48820
Abs 0.1% (=1 g/l)   0.463, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 49.47
This classifies the protein as unstable.



Aliphatic index: 72.62

Grand average of hydropathicity (GRAVY): -0.841