ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVQEQAILSC IEQTMVADAK IIKEAEQQLF EFQKQPGFTS FLLNIVSDDN FALNVRLSSA 

        70         80         90        100        110        120 
IYLKNKIHRS WDTKREDGIK ADEKLSIKER LIETLVKNCE NNHIRPILTE TINGILVGQE 

       130        140        150        160        170        180 
DWDLAPIIKN LLSSGDASYI YPGLLLLFQL CKAHRWDMVG SRDYIDSVIE ELFPIVEGIA 

       190        200        210        220        230        240 
SNIGSQTDYR SNEILYLILK SFKYACLNNL PQYFSQPERI MSWVQLHLYL CSKPLPVEVM 

       250        260        270        280        290        300 
ELDPADRSLD KRVKVNKWGF GNLNRFLQRY NKITKAITKE FIDYIFNTIV PIILREFFKD 

       310        320        330        340        350        360 
IEAWGNNSLW LSDSSLYFLI SFLEKCVTID QLYPLIEPHL QIIFENVIFP CLCANEQSIE 

       370        380        390        400        410        420 
LLEDDQEEYT RRYFDINREG STPDAASADF IFLIGSKRPE KLNNILPFIN DIFTRFDANS 

       430        440        450        460        470        480 
SDINMAFKEE GALRTLSNLF SFIDEPSVLE NIFGHFIVPL LSQDKYMFLV ARSLETIALY 

       490        500        510        520        530        540 
SEEFKDMNIL SQLFELTYTN FLNSNVLPVQ IEAADAIKCL IVSNPQIHPA VSAHVPGMME 

       550        560        570        580        590        600 
KLLKLSKIFE IDILSEVMEA LVERFSDELS PFAKDLASNL VEQFLRIAQA LVENPSETYS 

       610        620        630        640        650        660 
ASDQEQEIQA SGLLQTMTTM VMSMNKVPLI ESLAPVVKFV VLHAQISFIT EAVDLLDALT 

       670        680        690        700        710        720 
ISSHLLYNQI APPIWELLHD ILDSFQTYAM DYFEAYSIFF ETIVMTGFPQ DQTYVQPLLE 

       730        740        750        760        770        780 
ILSAKLESEV DYDIEHVMQI LMYFALSMRD IPLFSKAIKV STNDELGLDS KCIVKLGLAN 

       790        800        810        820        830        840 
LFAKPIETLQ IMENEGFTIN FFTNWFNEKF YSVFAIKLQV LVILTLLKMP EVPNSVSPLL 

       850        860        870        880        890        900 
NNLTNKLVEL TLSLPKAIRN RDAVTEGKSL EGDLTPEEEE EYFIECDDDM KETVLDQINV 

       910        920        930        940 
FQEVHTFFKN LQNEDAGKYE KIINYLDESK RDSLQVILEF VSQH 

References and documentation are available.

Number of amino acids: 944

Molecular weight: 108404.69

Theoretical pI: 4.61

Amino acid composition: 
Ala (A)  52	  5.5%
Arg (R)  27	  2.9%
Asn (N)  54	  5.7%
Asp (D)  56	  5.9%
Cys (C)  11	  1.2%
Gln (Q)  42	  4.4%
Glu (E)  82	  8.7%
Gly (G)  25	  2.6%
His (H)  14	  1.5%
Ile (I)  87	  9.2%
Leu (L) 119	 12.6%
Lys (K)  52	  5.5%
Met (M)  23	  2.4%
Phe (F)  59	  6.2%
Pro (P)  38	  4.0%
Ser (S)  71	  7.5%
Thr (T)  39	  4.1%
Trp (W)   9	  1.0%
Tyr (Y)  30	  3.2%
Val (V)  54	  5.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 138
Total number of positively charged residues (Arg + Lys): 79

Atomic composition:

Carbon      C	      4937
Hydrogen    H	      7696
Nitrogen    N	      1210
Oxygen      O	      1457
Sulfur      S	        34

Formula: C4937H7696N1210O1457S34
Total number of atoms: 15334

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    94825
Abs 0.1% (=1 g/l)   0.875, assuming all pairs of Cys residues form cystines


Ext. coefficient    94200
Abs 0.1% (=1 g/l)   0.869, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 48.75
This classifies the protein as unstable.



Aliphatic index: 107.20

Grand average of hydropathicity (GRAVY): 0.011