ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVRRWIPSGR HLRNNDNTGD DDDSEFTNSM DSGMSIPSLR DSMTTRSSHN DPIKPALMND 

        70         80         90        100        110        120 
SNKVKNLEKE LTNAKIKIQV LYEYIRRIPN KDGNAPSLGN DTDFRNSIIE GLNLEINKLK 

       130        140        150        160        170        180 
QDLKAKEVEY QDTLQFVQEN LENSESIVNT INHLLSFILT HFNEQDENAH LLDKEERETL 

       190        200        210        220        230        240 
EETLELSSDY VLEKMDTLSK FIIQFLQDFL HSKSRAESKQ DKEEFLSLAQ SSPAGSQLES 

       250        260        270        280        290        300 
RDSPSSKEEN TDGGYQNDEI HDSNNHIDTE NVMANSTSLP ISAVESRFEK TLDTQLEIVI 

       310        320        330        340        350        360 
EILHKEYDQF INSIRLKFEK SQKLEKIIAS KLNEQSHLLD SLELEENSSS VIEKQDHLIS 

       370        380        390        400        410        420 
QLKEKIESQS VLINNLEKLK EDIIKMKQNE KVLTKELETQ TKINKLKENN WDSYINDLEK 

       430        440        450        460        470        480 
QINDLQIDKS EEFHVIQNQL DKLDLENYQL KNQLNTLDNQ KLILSQYESN FIKFNQNLLL 

       490        500        510        520        530        540 
HLDSIFNILQ KILQESSIAQ FDRKMKSIKS VPNALKNLNL IQPKLESLYT FIETALESII 

       550        560        570        580        590        600 
NSYISSLISM ETPEQPHQQG NELTATPNKE LTLRIEELQR RWISERERRK LDANASEARI 

       610        620 
KALEQENESL RSKLFNLSIN NP 

References and documentation are available.

Number of amino acids: 622

Molecular weight: 72104.74

Theoretical pI: 4.97

Amino acid composition: 
Ala (A)  19	  3.1%
Arg (R)  23	  3.7%
Asn (N)  58	  9.3%
Asp (D)  40	  6.4%
Cys (C)   0	  0.0%
Gln (Q)  39	  6.3%
Glu (E)  69	 11.1%
Gly (G)  10	  1.6%
His (H)  14	  2.3%
Ile (I)  53	  8.5%
Leu (L)  79	 12.7%
Lys (K)  53	  8.5%
Met (M)  10	  1.6%
Phe (F)  19	  3.1%
Pro (P)  15	  2.4%
Ser (S)  65	 10.5%
Thr (T)  27	  4.3%
Trp (W)   3	  0.5%
Tyr (Y)  11	  1.8%
Val (V)  15	  2.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 109
Total number of positively charged residues (Arg + Lys): 76

Atomic composition:

Carbon      C	      3147
Hydrogen    H	      5076
Nitrogen    N	       872
Oxygen      O	      1041
Sulfur      S	        10

Formula: C3147H5076N872O1041S10
Total number of atoms: 10146

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    32890
Abs 0.1% (=1 g/l)   0.456

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 55.48
This classifies the protein as unstable.



Aliphatic index: 92.81

Grand average of hydropathicity (GRAVY): -0.778