ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVSLRSRKVI PASEMVSDGK TEKDASGDSP TSVLNEEENC EEKSVTVVEE EILLAKNGDS 

        70         80         90        100        110        120 
SLISEAMAQE EEQLLKLRED EEKANNAGSA VAPNLNETQF TKLDELLTQT QLYSEFLLEK 

       130        140        150        160        170        180 
MEDITINGIE SESQKAEPEK TGRGRKRKAA SQYNNTKAKR AVAAMISRSK EDGETINSDL 

       190        200        210        220        230        240 
TEEETVIKLQ NELCPLLTGG QLKSYQLKGV KWLISLWQNG LNGILADQMG LGKTIQTIGF 

       250        260        270        280        290        300 
LSHLKGNGLD GPYLVIAPLS TLSNWFNEIA RFTPSINAII YHGDKNQRDE LRRKHMPKTV 

       310        320        330        340        350        360 
GPKFPIVITS YEVAMNDAKR ILRHYPWKYV VIDEGHRLKN HKCKLLRELK HLKMDNKLLL 

       370        380        390        400        410        420 
TGTPLQNNLS ELWSLLNFIL PDIFTSHDEF ESWFDFSEKN KNEATKEEEE KRRAQVVSKL 

       430        440        450        460        470        480 
HGILRPFILR RMKCDVELSL PRKKEIIMYA TMTDHQKKFQ EHLVNNTLEA HLGENAIRGQ 

       490        500        510        520        530        540 
GWKGKLNNLV IQLRKNCNHP DLLQGQIDGS YLYPPVEEIV GQCGKFRLLE RLLVRLFANN 

       550        560        570        580        590        600 
HKVLIFSQWT KLLDIMDYYF SEKGFEVCRI DGSVKLDERR RQIKDFSDEK SSCSIFLLST 

       610        620        630        640        650        660 
RAGGLGINLT AADTCILYDS DWNPQMDLQA MDRCHRIGQT KPVHVYRLST AQSIETRVLK 

       670        680        690        700        710        720 
RAYSKLKLEH VVIGQGQFHQ ERAKSSTPLE EEDILALLKE DETAEDKLIQ TDISDADLDR 

       730        740        750        760 
LLDRSDLTIT APGETQAAEA FPVKGPGWEV VLPSSGGMLS SLNS 

References and documentation are available.

Number of amino acids: 764

Molecular weight: 86637.81

Theoretical pI: 6.01

Amino acid composition: 
Ala (A)  42	  5.5%
Arg (R)  40	  5.2%
Asn (N)  39	  5.1%
Asp (D)  43	  5.6%
Cys (C)  10	  1.3%
Gln (Q)  34	  4.5%
Glu (E)  70	  9.2%
Gly (G)  45	  5.9%
His (H)  18	  2.4%
Ile (I)  46	  6.0%
Leu (L)  94	 12.3%
Lys (K)  62	  8.1%
Met (M)  16	  2.1%
Phe (F)  22	  2.9%
Pro (P)  26	  3.4%
Ser (S)  55	  7.2%
Thr (T)  40	  5.2%
Trp (W)  10	  1.3%
Tyr (Y)  16	  2.1%
Val (V)  36	  4.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 113
Total number of positively charged residues (Arg + Lys): 102

Atomic composition:

Carbon      C	      3821
Hydrogen    H	      6145
Nitrogen    N	      1065
Oxygen      O	      1175
Sulfur      S	        26

Formula: C3821H6145N1065O1175S26
Total number of atoms: 12232

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    79465
Abs 0.1% (=1 g/l)   0.917, assuming all pairs of Cys residues form cystines


Ext. coefficient    78840
Abs 0.1% (=1 g/l)   0.910, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 44.36
This classifies the protein as unstable.



Aliphatic index: 90.63

Grand average of hydropathicity (GRAVY): -0.502