ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MVVRRKVHVL LIARSFHSYT PCFRVTTRGK RQRSKSKQQA KVELDHTREL DNDQATETVV 

        70         80         90        100        110        120 
DRSVGPEKDI ESINKDFLQR TKGLEPDIEL KQLPQIKQEF NQRYKDRYVK PSEDWYVNSW 

       130        140        150        160        170        180 
RSLTKPKIPL YKLINSDFQL ITKLKAPNPM EFQPVQLMES PLNVGDFVLL KMRPNELAMC 

       190        200        210        220        230        240 
VSLPSSTMDP RYTFVTIDGT MCFATKNRVL LRIPHKLPAG IHSLIQPESH HKHLPIGTVK 

       250        260        270        280        290        300 
NFSNQTNILP IVARQLITSR YPAQISKLAW KDLPITTKKL QLLHRSLQNY MGPWQIPFFT 

       310        320        330        340        350        360 
LVGLVQKLDL NKALDDKNGI NYLTSLVNNY HTVNDIPINS PTFVSTYWAI MQQQESNLWG 

       370        380        390        400        410        420 
EIHLNTALLS PISVTIIPLK SQHLYYAQVI EKLEANSYRE VNKFVKLVNE RKYRDISALY 

       430        440        450        460        470        480 
PSVIQLLKDF AAGNFHNNGI IVALISKIFR KIERYKDCDI TRDICQDLIN EITPNSIPNP 

       490        500        510        520        530        540 
LLLNMDLALP ASSKLVKWQQ KLYDLTNIEE LQWKKSGTDD DRYDFGDLRV FCIDSETAHE 

       550        560        570        580        590        600 
IDDGVSVKNY GRDGLYTLYI HIADPTSMFP ESTNVDIEGI STDILNVALK RSFTTYLPDT 

       610        620        630        640        650        660 
VVPMLPQSIC HLSDLGKQGQ RTKTISFSVD VKITSKCSGK SIEIMYDSFK IRKGIVSNFP 

       670        680        690        700        710        720 
KATYEDVDRI LGTPNSEASP VKKDLESLSM ISKLLREQRI KNSNAVIFGE GFNKGLVMLN 

       730        740        750        760        770        780 
ADSEGELTEV TFSDQEETLS TILVSEMMIL ANTLTGRYFA ENKIGGVFRC YKQLPLGEVA 

       790        800        810        820        830        840 
QQQYDSMITS TKKGIFPKLK DIVKLSSLLN SSFYTGRPFR HEMIGAKQYL TVTSPLRRFP 

       850        860        870        880        890        900 
DLINHLQIHR HLQKKPLCFN QTQIDSLIWP IQSRADILKR ASRNSSTYWT LNYLKKLTKL 

       910        920        930        940        950        960 
EPERTFDVMV TSVPQNGFTG CVFPDLSFAR GTLKLHPSSM HYPMIGDIVK NCKISKIDCL 


EGMLELEKL 

References and documentation are available.

Number of amino acids: 969

Molecular weight: 110822.09

Theoretical pI: 9.11

Amino acid composition: 
Ala (A)  35	  3.6%
Arg (R)  47	  4.9%
Asn (N)  51	  5.3%
Asp (D)  56	  5.8%
Cys (C)  13	  1.3%
Gln (Q)  46	  4.7%
Glu (E)  47	  4.9%
Gly (G)  40	  4.1%
His (H)  22	  2.3%
Ile (I)  76	  7.8%
Leu (L) 107	 11.0%
Lys (K)  77	  7.9%
Met (M)  23	  2.4%
Phe (F)  38	  3.9%
Pro (P)  52	  5.4%
Ser (S)  77	  7.9%
Thr (T)  62	  6.4%
Trp (W)  10	  1.0%
Tyr (Y)  33	  3.4%
Val (V)  57	  5.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 103
Total number of positively charged residues (Arg + Lys): 124

Atomic composition:

Carbon      C	      4979
Hydrogen    H	      7942
Nitrogen    N	      1338
Oxygen      O	      1445
Sulfur      S	        36

Formula: C4979H7942N1338O1445S36
Total number of atoms: 15740

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   104920
Abs 0.1% (=1 g/l)   0.947, assuming all pairs of Cys residues form cystines


Ext. coefficient   104170
Abs 0.1% (=1 g/l)   0.940, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 39.90
This classifies the protein as stable.



Aliphatic index: 94.32

Grand average of hydropathicity (GRAVY): -0.314