ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MYKLQVVLVP PSLQATMPIQ FGYGPTIAES SQLLPNRTNM AQSAGDASLQ YANLRSANVS 

        70         80         90        100        110        120 
FTPSYFNQSR FRKFLLFTKP TNTLLNLSDE IIDKCEKMYP SLQEDIEILS LQDNSGCDLD 

       130        140        150        160        170        180 
PDFLVKDVFN VNNIVRVILK NEIDLDDSAP VSLYKSVKRS KLNNGSPQSV QPQQQIPSSS 

       190        200        210        220        230        240 
GVLRIAKKRP PTGTTTTTTI RSATNGSMRV STPLARQIYP PPSSKIVSNN SDDEDEDIGE 

       250        260        270        280        290        300 
RSFLPPPTQP QSPPIRISSG IDAGKKIKSS IVEEDIVSRS ATVDPDKTKQ QRLLSGTPIM 

       310        320        330        340        350        360 
STMTPNRVTL TGQRVVSEHA HKNELVFSAS ASSSSFANGG TAAVTAQDIN RKPPVTTPRI 

       370        380        390        400        410        420 
TSGMLKIPEP RISEIEKELK EGPSSPASIL PAKAAKIPMK KPYLENGENY ESDDSSSSEN 

       430        440        450        460        470        480 
QETPETEPHS KASLQRSQSS IADNNGSPVK NSPLGDAMPH NVHLAELPKA SNTSITKSSN 

       490        500        510        520        530        540 
GESWGKQQEH QPPRKSSLET IVEKKSQAEP SGIVEPKRMT NFLDDNQVRE KEDTNDKLLE 

       550        560        570        580        590        600 
KEILPTIPHN DQPILASSDK SNGTLKSLAG KVSSNNNASK EDGTIINGTI EDDGNDNDEV 

       610        620        630        640        650        660 
DTTVRIVPQD SDSSSFPKSD LFKMIEGDDT DLPQWFKGKN SRTSGNSKNS KPYTTVLNKD 

       670        680        690        700        710        720 
IDNSKPDPRN ILPQRTPRSA AKRAAQLLAG AKKNEVPQKS TEDSSSAAST DDESESGIET 

       730        740        750        760        770        780 
DFSSDDDFKR KNMSVPNNGP KDISLHSLKG SVVPVKDSKI INKEVDEERN DKRDSQKKSA 

       790        800        810        820        830        840 
VSESSVTNSK ISEQMAKSFY PNSNKKQNEA TKVETKPATQ ASSFPVVGGS PSVATKGTTS 

       850        860        870        880        890        900 
FNEEGNRKNV KTKAKNESAQ IDRQQKETTS RVADLKSANI GGEDLNKKAE GSKEPEKASA 

       910        920        930        940        950        960 
NIQDANDKNN SKEKEDSKSK QVSQKKLKMT DHLKEGNVQL PKPSANDKLK DLKAKFTNSK 

       970        980        990       1000       1010       1020 
TLVPPGIISN EKNNSSANDD DSSSSGSSTE DESSSSSSSS DEETSTSRKA RRVVVNTPRE 

      1030       1040       1050       1060       1070       1080 
PVRSSSKIEA PSPSVNKKIN ATPDKIPVTQ LMDMSSPPSV KSKTTSNPSS ILHDLPRKVR 

      1090       1100       1110       1120       1130       1140 
PSLSSLSDLV SRGIPDVKEK TSKSNEKSQT KAPSSSDDES SSDSDSNSSS DSVSDSSSDS 

      1150       1160       1170       1180 
KSESDSDDSG DSSDDGKSFI SAKSASAALG KKKKPSGGFA SLIKDFKKK 

References and documentation are available.

Number of amino acids: 1189

Molecular weight: 128530.92

Theoretical pI: 7.56

Amino acid composition: 
Ala (A)  67	  5.6%
Arg (R)  44	  3.7%
Asn (N)  80	  6.7%
Asp (D)  91	  7.7%
Cys (C)   2	  0.2%
Gln (Q)  48	  4.0%
Glu (E)  74	  6.2%
Gly (G)  51	  4.3%
His (H)  10	  0.8%
Ile (I)  60	  5.0%
Leu (L)  68	  5.7%
Lys (K) 122	 10.3%
Met (M)  17	  1.4%
Phe (F)  24	  2.0%
Pro (P)  86	  7.2%
Ser (S) 197	 16.6%
Thr (T)  73	  6.1%
Trp (W)   2	  0.2%
Tyr (Y)  11	  0.9%
Val (V)  62	  5.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 165
Total number of positively charged residues (Arg + Lys): 166

Atomic composition:

Carbon      C	      5472
Hydrogen    H	      8951
Nitrogen    N	      1593
Oxygen      O	      1929
Sulfur      S	        19

Formula: C5472H8951N1593O1929S19
Total number of atoms: 17964

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    27515
Abs 0.1% (=1 g/l)   0.214, assuming all pairs of Cys residues form cystines


Ext. coefficient    27390
Abs 0.1% (=1 g/l)   0.213, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 55.93
This classifies the protein as unstable.



Aliphatic index: 62.74

Grand average of hydropathicity (GRAVY): -0.925